Effect of Oxidative Stress on Transition Dairy Cow Mastitis and Its Regulation Mechanisms

MA Yanfen, SONG Liwen, GAO Min, WANG Lifang

doi:10.3969/j.issn.1006-267x.2015.03.002

Chinese Journal of Animal Nutrition >

2015 , Vol. 27 >Issue 3: 671 - 676

DOI: https://doi.org/10.3969/j.issn.1006-267x.2015.03.002

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Effect of Oxidative Stress on Transition Dairy Cow Mastitis and Its Regulation Mechanisms

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1. Institute of Animal Nutrition and Feed, Inner Mongolia Academy of Agriculture and Animal Husbandry Sciences, Inner Mongolia Autonomous Region Key Laboratory of Herbivorous Animal Nutrition Science, Huhhot 010031, China;
2. Institute of Resources Environment and Detection Technology, Inner Mongolia Academy of Agriculture and Animal Husbandry Sciences, Huhhot 010031, China

Received date: 2014-10-03

Online published: 2015-03-18

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Abstract

Dairy cow mastitis is a common metabolic disease of cows, and with an increasing incidence rate. Recently, Oxidative stress is a major problem in the dairy farming industry, it plays a key role in the cow mammary gland cells induced damage or dysfunction, which is mainly the reduction of antioxidative function in the production and scavenging of free radicals caused by the imbalance. And sustained oxidative stress can generate large amounts of oxygen free radicals that affect the metabolism, proliferation and differentiation of normal cells. It may also further induce the autoimmune response to form a waterfall effect, causing irreversible damage of the mammary epidermal cell. Nuclear factor E2-related factor 2-antioxidant response element (Nrf2-ARE) signaling pathway plays an important function in the defense against exogenous stimulation and oxidative stress. Oxidative stress, oxidative stress and transition cow mastitis, oxidative stress regulation mechanisms for animals themselves were summarized in this article, which had important significance to ensure that the dairy cows can maintain a healthy body, play the normal function of lactation and improve production performance during transition.

Key words： oxidative stress; transition dairy cow; mastitis; Nrf2-ARE signaling pathway; regulation mechanisms

Cite this article

MA Yanfen, SONG Liwen, GAO Min, WANG Lifang . Effect of Oxidative Stress on Transition Dairy Cow Mastitis and Its Regulation Mechanisms[J]. Chinese Journal of Animal Nutrition, 2015 , 27(3) : 671 -676 . DOI: 10.3969/j.issn.1006-267x.2015.03.002

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