ZHANG Xin, LI Fangfang, ZHU Yujing, ZHENG Lili, ZHANG Yong . Melanocortin-4 Receptor: Biological Characteristics, Mechanism and Influence Factors[J]. Chinese Journal of Animal Nutrition, 2015 , 27(3) : 683 -690 . DOI: 10.3969/j.issn.1006-267x.2015.03.004

[1] TODOROVIC A,HASKELL-LUEVANO C.A review of melanocortin receptor small molecule ligands[J].Peptides,2005,26(10):2026-2036.  

[2] SRINIVASAN S,LUBRANO-BERTHELIER C,GOVAERTS C,et al.Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans[J].The Journal of Clinical Investigation,2004,114(8):1158-1164.  

[3] ADAN R A H,GISPEN W H.Brain melanocortin receptors:from cloning to function[J].Peptides,1997,18(8):1279-1287.  

[4] ABDEL-MALEK Z A.Melanocortin receptors:their functions and regulation by physiological agonists and antagonists[J].Cellular and Molecular Life Sciences,2001,58(3):434-441.  

[5] BREIT A,BVCH T R H,BOEKHOFF I,et al.Alternative G protein coupling and biased agonism:new insights into melanocortin-4 receptor signalling[J].Molecular and Cellular Endocrinology,2011,331(2):232-240.  

[6] YANG Y K.Structure,function and regulation of the melanocortin receptors[J].European Journal of Pharmacology,2011,660(1):125-130.  

[7] WEI R B,YUAN D Y,ZHOU C W,et al.Cloning,distribution and effects of fasting status of melanocortin 4 receptor (MC4R) in Schizothorax prenanti[J].Gene,2013,532(1):100-107.  

[8] KIM K S,LARSEN N,SHORT T,et al.A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness,growth,and feed intake traits[J].Mammalian Genome,2000,11(2):131-135.  

[9] GANTZ I,MIWA H,KONDA Y,et al.Molecular cloning,expression,and gene localization of a fourth melanocortin receptor[J].The Journal of Biological Chemistry,1993,268(20):15174-15179.

[10] SWITONSKI M,MANKOWSKA M,SALAMON S.Family of melanocortin receptor (MCR) genes in mammals-mutations,polymorphisms and phenotypic effects[J].Journal of Applied Genetics,2013,54(4):461-472.  

[11] KIM K S,LARSEN N J,ROTHSCHILD M F.Rapid communication:linkage and physical mapping of the porcine melanocortin-4 receptor (MC4R) gene[J].Journal of Animal Science,2000,78(3):791-792.

[12] 聂茹,巴彩凤.黑皮质素受体-4调节通路的研究进展[J].中国实验动物学报,2008,16(4):317-320.

[13] ADAN R A H,TIESJEMA B,HILLEBRAND J J G,et al.The MC4 receptor and control of appetite[J].British Journal of Pharmacology,2006,149(7):815-827.  

[14] PALUCKI B L,PARK M K,NARGUND R P,et al.Discovery of (2S)-N-[(1R)-2- -1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243),a potent and selective melanocortin subtype-4 receptor agonist[J].Bioorganic & Medicinal Chemistry Letters,2005,15(1):171-175.  

[15] 张志岐,束刚,江青艳.下丘脑对脂类的营养感应及其参与食欲调控的机制[J].动物营养学报,2013,25(7):1395-1405.

[16] 郑溜丰,彭健.中枢神经系统整合外周信号调节采食量的分子机制[J].动物营养学报,2013,25(10):2212-2221.

[17] WYNNE K,STANLEY S,MCGOWAN B,et al.Appetite control[J].Journal of Endocrinology,2005,184(2):291-318.  

[18] 施忠秋,齐智利.γ-氨基丁酸调控采食量和缓解热应激的机制[J].动物营养学报,2014,26(1):49-53.

[19] SCHWARTZ M W,WOODS S C,PORTE D,et al.Central nervous system control of food intake[J].Nature,2000,404(6778):661-671.

[20] MORTON G J,CUMMINGS D E,BASKIN D G,et al.Central nervous system control of food intake and body weight[J].Nature,2006,443(7109):289-295.  

[21] PORTE D,Jr,BASKIN D G,SCHWARTZ M W.Leptin and insulin action in the central nervous system[J].Nutrition Reviews,2002,60(10 Pt 2):S20-S29.

[22] SIMPSON K A,MARTIN N M,BLOOM S R.Hypothalamic regulation of food intake and clinical therapeutic applications[J].Arquivos Brasileiros de Endocrinologia & Metabologia,2009,53(2):120-128.

[23] 桑军亮,田科雄.瘦素调节动物采食量及能量代谢的研究进展[J].湖南饲料,2011(1):34-37.

[24] 梁亮,魏晓莉,孙彭利,等.新型黑皮质素4受体激动剂减肥作用研究[J].解放军药学学报,2009,25(5):386-390.

[25] MARSH D J,HOLLOPETER G,HUSZAR D,et al.Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides[J].Nature Genetics,1999,21(1):119-122.  

[26] PIMENTEL G D,ROPELLE E R,ROCHA G Z,et al.The role of neuronal AMPK as a mediator of nutritional regulation of food intake and energy homeostasis[J].Metabolism:Clinical and Experimental,2013,62(2):171-178.  

[27] DANSINGER M L,GLEASON J A,GRIFFITH J L,et al.Comparison of the atkins,ornish,weight watchers,and zone diets for weight loss and heart disease risk reduction:a randomized trial[J].The Journal of the American Medical Association,2005,293(1):43-53.  

[28] WANG S B,KHONDOWE P,CHEN S F,et al.Effects of "Bioactive"amino acids leucine,glutamate,arginine and tryptophan on feed intake and mRNA expression of relative neuropeptides in broiler chicks[J].Journal of Animal Science and Biotechnology,2012,3:27.

[29] KHONDOWE P.脑室注射不同氨基酸对肉鸡采食的调控作用及其分子机制[D].硕士学位论文.广州:华南农业大学,2010.

[30] ROPELLE E R,PAULI J R,FERNANDES A M F,et al.A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss[J].Diabetes,2008,57(3):594-605.  

[31] 王诗男,蒋正尧.α-MSH对下丘脑葡萄糖敏感神经元活动的调制作用[J].青岛大学医学院学报,2011,47(2):95-97.

[32] KIM M S,PARK J Y,NAMKOONG C,et al.Anti-obesity effects of α-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase[J].Nature Medicine,2004,10(7):727-733.  

[33] CHA S H,WOLFGANG M,TOKUTAKE Y,et al.Differential effects of central fructose and glucose on hypothalamic malonyl-CoA and food intake[J].Proceedings of the National Academy of Sciences of the United States of America,2008,105(44):16871-16875.  

[34] BELGARDT B F,OKAMURA T,BRVNING J C.Hormone and glucose signalling in POMC and AgRP neurons[J].The Journal of Physiology,2009,587(22):5305-5314.  

[35] OBICI S,FENG Z H,MORGAN K,et al.Central administration of oleic acid inhibits glucose production and food intake[J].Diabetes,2002,51(2):271-275.  

[36] SCHWINKENDORF D R,TSATSOS N G,GOSNELL B A,et al.Effects of central administration of distinct fatty acids on hypothalamic neuropeptide expression and energy metabolism[J].International Journal of Obesity,2011,35(3):336-344.