Effects of Complex Antibacterial Peptide on Growth Performance and Serum Cytokine Contents of Weaned Piglets

YUAN Wei, REN Zhihua, DENG Youtian, DENG Huidan, DENG Junliang, HU Yang

doi:10.3969/j.issn.1006-267x.2015.03.028

Chinese Journal of Animal Nutrition >

2015 , Vol. 27 >Issue 3: 885 - 892

DOI: https://doi.org/10.3969/j.issn.1006-267x.2015.03.028

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Effects of Complex Antibacterial Peptide on Growth Performance and Serum Cytokine Contents of Weaned Piglets

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1. Key Laboratory of Animal Diseases and Environmental Hazard of Sichuan Province, Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary, Sichuan Agricultural University, Ya'an 625014, China;
2. Rota Bioengineering Co., Ltd., Chengdu 610000, China

Received date: 2014-09-22

Online published: 2015-03-18

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Abstract

This experiment was conducted to investigate the effects of complex antibacterial peptide on growth performance and serum cytokine contents of weaned piglets. Ninety 26-day-old healthy crossed weaned piglets (Duroc×Landrace×Yorkshire) were randomly divided into 5 groups with 3 replicates per group and 6 piglets per replicate according to the similar body weight, and half male and half female. The piglets in control group were fed a basal diet and those in experimental groups were fed the basal diet supplemented with 400 mg/kg Astragalus polysaccharide, and 250, 500, 1 000 mg/kg complex antibacterial peptide, respectively. The experiment period was 28 days. The results showed as follows: 1) compared with the control group, the supplementation of 250, 500 and 1 000 mg/kg complex antibacterial peptide and 400 mg/kg Astragalus polysaccharide could improve the average daily gain and decrease the ratio of feed to gain of weaned piglets, and the effects of the 1 000 mg/kg complex antibacterial peptide were better than those of 400 mg/kg Astragalus polysaccharide. 2) Compared with the control group, the supplementation of 250 mg/kg complex antibacterial peptide could significantly improve the contents of serum interleukin (IL)-2 (46 and 53 days of age), IL-4 (39, 46 and 53 days of age), IL-6 (39, 46 and 53 days of age), interferon-γ (IFN-γ) (32, 39, 46 and 53 days of age) and tumor necrosis factor-α (TNF-α) (53 days of age) (P<0.05 or P<0.01). During the entire experimental period, except the supplementation of 500 mg/kg complex antibacterial peptide had no significant effects on serum IL-2 and IL-4 contents of weaned piglets at the age of 32 days and the supplementation of 1 000 mg/kg complex antibacterial peptide had no significant effects on serum IL-4 content of weaned piglets at the age of 32 days (P>0.05), the contents of serum IL-2, IL-4, IL-6, IFN-γ and TNF-α were significantly improved by the supplementation of 500 and 1 000 mg/kg complex antibacterial peptide (P<0.05 or P<0.01), and the effects of them were better than those of 400 mg/kg Astragalus polysaccharide. In conclusion, the supplementation of complex antibacterial peptide can enhance the growth performance and immune function of weaned piglets, and the 1 000 mg/kg complex antibacterial peptide supplementation has the better effects.

Key words： complex antibacterial peptide; weaned piglets; growth performance; cytokines

Cite this article

YUAN Wei, REN Zhihua, DENG Youtian, DENG Huidan, DENG Junliang, HU Yang . Effects of Complex Antibacterial Peptide on Growth Performance and Serum Cytokine Contents of Weaned Piglets[J]. Chinese Journal of Animal Nutrition, 2015 , 27(3) : 885 -892 . DOI: 10.3969/j.issn.1006-267x.2015.03.028

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