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Effects of Pectinase Produced by Penicillium oxalicum Currie & Thom on Body Weight, Lipid Deposition and Lipid Metabolism of Obese Model Rats

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  • Nutrition and Feed Laboratory of China Agriculture Research System, Institute of High Quality Waterfowl, Qingdao Agricultural University, Qingdao 266109, China

Received date: 2014-11-01

  Online published: 2015-05-13

Abstract

This experiment was conducted to study the effects of pectinase produced by Penicillium oxalicum Currie & Thom on body weight, lipid deposition and lipid metabolism of obese model rats. A total of 108 male rats with body weight of 220 to 240 g, adapted feeding 3 days. The rats were divided into control group (group Ⅰ), hyperlipidemia group (group Ⅱ) and other hyperlipidemia model groups. After successful modeling, the rats were randomly divided into 7 groups with 3 replicates per group and 4 rats per replicate. Rats in the 7 groups were fed the basal diets supplemented with 0 (group Ⅲ), 0.01% (group Ⅳ), 0.05% (group Ⅴ), 0.1% (group Ⅵ), 0.2% (group Ⅶ), 0.4% (group Ⅷ) and 0.8% (group Ⅸ) pectinase, respectively. The experiment last for 8 weeks. The results showed as follows: 1) the pectinase produced by Penicillium oxalicum Currie & Thom could restrain the increasing weight, decreased the Lee's index and control portion size of obese model rats. 2) The pectinase could significantly reduce the amount of lipid deposition of obese model rats. 3) The pectinase could restore the fatty liver disease of obese model rats to the normal level due to intake of high-fat diet. 4) The pectinase could reduce the content of total cholesterol, total triglyceride, low-density lipoprotein cholesterol and nonesterified fatty acid in serum of obese model rats, and increase the serum high-density lipoprotein cholesterol content. 5) It also could reduce the activity of aspartate transaminase and alanine aminotransferase in serum of obese model rats, and increase the activity of serum lipoprotein lipase and hepaticendothelaillipase in serum. In conclusion, the pectinase produced by Penicillium oxalicum Currie & Thom has significant effect on reducing the deposition and serum lipid of obese model rats.

Cite this article

XU Xiaobo, WANG Baowei, GE Wenhua, ZHANG Mingai, XIE Chao . Effects of Pectinase Produced by Penicillium oxalicum Currie & Thom on Body Weight, Lipid Deposition and Lipid Metabolism of Obese Model Rats[J]. Chinese Journal of Animal Nutrition, 2015 , 27(5) : 1650 -1658 . DOI: 10.3969/j.issn.1006-267x.2015.05.038

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