Dietary Lactobacillus rhamnosus GG Supplementation Alleviates the Oxidant Stress Induced by Rotavirus in Weaned Piglets

TANG Jun, WANG Aina, CHEN Daiwen, MAO Xiangbing, CHEN Hao, LIU Minghui, YU Bing, HE Jun, ZHENG Ping, YU Jie, WANG Qunyuan

doi:10.3969/j.issn.1006-267x.2015.06.015

2015 , Vol. 27 >Issue 6: 1787 - 1793

DOI: https://doi.org/10.3969/j.issn.1006-267x.2015.06.015

Feed Science and Technology

Dietary Lactobacillus rhamnosus GG Supplementation Alleviates the Oxidant Stress Induced by Rotavirus in Weaned Piglets

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1. Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education, Ya'an 625014, China;
2. Weifang Business Vocational College, Zhucheng 262234, China

Received date: 2015-01-21

Online published: 2015-06-17

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Abstract

This experiment was aimed at investigate the effects of dietary Lactobacillus rhamnosus GG (LGG) supplementation on the oxidant stress induced by rotavirus (RV) challenge in weaned piglets. Twenty-four healthy crossbred (Duroc×Landrace×Yorkshire) castration piglets with body weight of (6.69±0.32) kg weaned at age of 21 days were used in the experiment. A 2×2 factorial design was used. Dietary supplementing LGG levels were 0 and 10⁹ CFU/kg, respectively. The piglets were orally infused with RV or not (sterilized MEM medium) on the morning of day 15. The experiment lasted for 19 days. The results showed that rotavirus challenge significantly enhanced diarrhea index, feed to gain ratio (F/G) and the malondialdehyde (MDA) level of the duodenum, jejunum, ileum and serum in the piglets (P<0.05), significantly inhibited the total superoxide dismutase (T-SOD) activity of the jejunum and the glutathione peroxidase (GSH-Px) activity of the duodenum, jejunum, ileum and serum in the piglets (P<0.05), and significantly reduced the total antioxidant capacity (T-AOC) of the jejunum and serum in the piglets (P<0.05). Dietary LGG supplementation significantly affected diarrhea index, F/G, the MDA level and T-SOD activity of the jejunum, the GSH-Px activity of serum and the T-AOC of jejunum and serum in the piglets (P<0.05). In addition, dietary LGG supplementation might, in a certain extent, significantly alleviate the effects of RV challenge on the diarrhea and antioxidant capacity of the piglets. These results suggest that dietary LGG supplementation reduces the diarrhea induced by rotavirus infection, and improves the F/G of the piglets, which can be due that dietary LGG supplementation may increase the antioxidant capacity of the body (intestine especially), inhibit the production of lipid peroxides and free radicals, and maintain the normal antioxidant system.

Key words： Lactobacillus rhamnosus GG; weaned piglets; rotavirus; performance; antioxidant capacity

Cite this article

TANG Jun, WANG Aina, CHEN Daiwen, MAO Xiangbing, CHEN Hao, LIU Minghui, YU Bing, HE Jun, ZHENG Ping, YU Jie, WANG Qunyuan . Dietary Lactobacillus rhamnosus GG Supplementation Alleviates the Oxidant Stress Induced by Rotavirus in Weaned Piglets[J]. Chinese Journal of Animal Nutrition, 2015 , 27(6) : 1787 -1793 . DOI: 10.3969/j.issn.1006-267x.2015.06.015

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