Feed Security

Nutritional Compound Additive Alleviates Jejunal Mucosal Structure Disruption of Piglets Challenged with Feed Containing Corn Contaminated with Mycotoxins

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  • Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Ya'an 625014, China

Received date: 2015-01-20

  Online published: 2015-06-17

Abstract

This experiment was conducted to study the protective effects of nutritional compound additive on jejunal mucosal structure and function, redox status and the numbers of bacteria in caecum and colon content of weaned piglets challenged-with feed contained corn naturally contaminated with mycotoxins. Eighteen "Duroc×Landrace×Large White" piglets were randomly allocated to control group, naturally contaminated corn group and naturally contaminated corn+0.2% nutritional compound additive group (6 replicates per group and 1 piglet per replicate). The trial lasted for 30 d. The results showed that corn naturally contaminated with mycotoxins significantly increased the serum diamine oxidase (DAO) activity on day 30 (P<0.01) and the content of methane dicarboxylic aldehyde (MDA) in jejuna mucosa (P<0.01), significantly decreased total antioxidation capability (T-AOC) (P<0.01), superoxide dismutase (SOD) (P<0.01) and glutathione peroxidase (GSH-Px) (P<0.05) activities in jejuna mucosa, as well as the number of Lactobacillus in caecum and colon chyme and the number of total bacteria in caecum chyme compared to the control group (P<0.05). The 0.2% nutritional compound additive significantly decreased the serum DAO activity (P<0.01) and the content of MDA in jejuna mucosa (P<0.05), significantly increaed GSH-Px activity in jejuna mucosa (P<0.01), and significantly up-regulated the mRNA expression of jejunal occludin (P<0.05), zonula-1 (ZO-1) (P<0.01) and solute carrier family 7 member 1 (SLC7A1) (P<0.05), in comparison with the corn naturally contaminated with mycotoxins group. Collectively, these results indicate that dietary mycotoxins can increase the intestinal permeability, and decrease the antioxidant capacity of jejunum mucosa and the numbers of Lactobacillus in caecum and colon contents. Meanwhile, dietary supplementation with 0.2% nutritional compound additive can alleviate the damage of jejuna mucosal structure and lipid peroxidation of jejunum in piglets fed mold-contaminated feeds, in a certain degree.

Cite this article

GAO Yiqing, CHEN Daiwen, TIAN Gang, ZHENG Ping, YU Jie, MAO Xiangbing, HE Jun, HUANG Nengjin, YU Bing . Nutritional Compound Additive Alleviates Jejunal Mucosal Structure Disruption of Piglets Challenged with Feed Containing Corn Contaminated with Mycotoxins[J]. Chinese Journal of Animal Nutrition, 2015 , 27(6) : 1813 -1822 . DOI: 10.3969/j.issn.1006-267x.2015.06.018

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