Molecular Nutrition

Regulation of Intestinal Mucosal Immune System by Lactobacillus in Piglets and Its Molecular Mechanisms

  • MA Xianyong ,
  • JIANG Zongyong ,
  • WANG Zhilin ,
  • WANG Li ,
  • YANG Xuefen ,
  • WU Yunpeng ,
  • HU Youjun
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  • Institute of Animal Science, Guangdong Academy of Agricultural Sciences, The Key Laboratory of Animal Nutrition and Feed Science (South China) of Ministry of Agriculture, State Key Laboratory of Livestock and Poultry Breeding, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangzhou 510640, China

Received date: 2015-02-10

  Online published: 2015-08-13

Abstract

Lactobacillus is known to be the edible bacterium and plays an important role in maintaining intestinal health, promoting the development and maturation of the immune system. This article summarized its functions and mechanism including the role of Lactobacillus in the intestine of piglets, the mutual recognition between Lactobacillus and the host cell receptor and their mediated immune regulation signal research, the metabolites such as lactic acid, Lactobacillus peptides exert immune regulation function. This review would provide the scientific theory basis for reasonable application of Lactobacillus, and the reference for the clinical research and application of Lactobacillus.

Cite this article

MA Xianyong , JIANG Zongyong , WANG Zhilin , WANG Li , YANG Xuefen , WU Yunpeng , HU Youjun . Regulation of Intestinal Mucosal Immune System by Lactobacillus in Piglets and Its Molecular Mechanisms[J]. Chinese Journal of Animal Nutrition, 2015 , 27(8) : 2317 -2322 . DOI: 10.3969/j.issn.1006-267x.2015.08.001

References

[1] ZHANG J,DENG J,WANG Z,et al.Modulatory effects of Lactobacillus salivarius on intestinal mucosal immunity of piglets[J].Current Microbiology,2011,62(5):1623-1631.  

[2] AHRNE S,HAGSLATT M L.Effect of Lactobacilli on paracellular permeability in the gut [J].Nutrients,2011,3(1):104-117.

[3] KONSTANTINOV S R,SMIDT H,MENGHERI E.Commensal microbiota is required for the normal development and function of the porcine host immune system and physiology[J].Nutrition and Immunity,2006(1):23-38.

[4] ZHANG L,XU Y Q,LIU H Y,et al.Evaluation of Lactobacillus rhamnosus GG using an Escherichia coli K88 model of piglet diarrhoea:effects on diarrhoea incidence,faecal microflora and immune responses[J].Veterinary Microbiology,2010,141(1/2):142-148.  

[5] KILIÇ G B,KULEASAN H,SÖMER V F,et al.Determining potential probiotic properties of human originated Lactobacillus plantarum strains[J].Biotechnology and Bioprocess Engineering,2013,18(3):479-485.10  

[6] KAWAI T,AKIRA S.The role of pattern-recognition receptors in innate immunity:update on Toll-like receptors[J].Nature Immunology,2010,11(5):373-384.  

[7] LEBEER S,VANDERLEYDEN J,DE KEERSMAECKER S C.Host interactions of probiotic bacterial surface molecules:comparison with commensals and pathogens[J].Nature Reviews Microbiology,2010,8(3):171-184.  

[8] SASAKI T,FUKAMI S,NAMIOKA S.Enhanced resistance of mice to Eschefichia coli infection induced by administration of peptidoglycan derived from Bifidobacterium thermophilum[J].Journal of Veterinary Medical Science,1994,56(3):433-437.  

[9] NAGAOKA M,HASHIMOTO S,WATANABE T,et a1.Anti-ulcer effects of lactic acid bacteria and their cell wall polysaccharides[J].Biological & Pharmaceutical Bulletin,1994,17(8):1012-1017.  

[10] MATSUGUCHI T,TAKAGI A,MATSUZAKI T,et a1.Lipoteichoicacids from Lactobacillus strains elicit strongtumor necrosis factoralpha-indacingactivities inmacrophages through Toll-like receptor 2[J].Clinical and Diagnostic Laboratory Immunology,2003,10(2):259-266.

[11] SHIDA K,KIYOSHIMA-SHIBATA J,KAJI R,et a1.Peptidoglycanfrom Lactobacilli inhibits interleukin 12 production by macrophagesinducedby Lactobacillus casei through Toll-like receptor 2 dependent and inde-pendent mechanisms [J].Immunology,2009,128:858-869.  

[12] SHIMAZU T.Immunobiotic Lactobacillus jensenii elicit anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the Toll-like receptor signaling pathway[J].Infection and Immunity,2012,80:276-288.  

[13] CARIO E,GERKEN G,PODOLSKY D K,et al.Toll-like receptor 2 enhances ZO-1 assoeiated intestinal epithelial barrier integrity via protein kinase C [J].Gastroenterology,2004,127(1):224-238.  

[14] KARLSSON M,SCHERBAK N,REID G,et al.Lactobacillus rhamnosus GR-1 enhances NF-kappaB activation in Escherichia coli-stimulated urinary bladder cells through TLR4[J].BMC Microbiology,2012,12:15.  

[15] GRANGETTE C,NUTTEN S,PALUMBO E,et al.Enhanced antiinflammatory capacity of a Lactobacillus plantarum mutant synthesizing modified teichoic acids[J].Proceedings of the National Academy of Sciences of the United States of America,2005,102(29):10321-10326.  

[16] 杨宽民.植物乳杆菌对感染大肠杆菌K88幼龄仔猪肠道健康的影响[D].博士学位论文.中山:中山大学,2013.

[17] SHAH M M,SAIO M,YAMASHITA H,et al.Lactobacillus acidophilus strain L-92 induces CD4+CD25+Foxp3+regulatory T cells and suppresses allergic contact dermatitis[J].Biological and Pharmaceutical Bulletin,2012,35(4):612-616.  

[18] RYO A,SUIZU F,YOSHIDA Y,et al.Regulation of NF-κB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA[J].Molecular Cell,2003,12:1413-1426.  

[19] DALY K,DARBY A C,HALL N,et al.Dietary supplementation with lactose or artificial sweetener enhances swine gut Lactobacillus population abundance[J].British Journal of Nutrition,2014,2:1-6.

[20] PASZTI-GERE E,SZEKER K,CSIBRIK-NEMETH E,et al.Metabolites of Lactobacillus plantarum 2142 prevent oxidative stress-induced overexpression of proinflammatory cytokines in IPEC-J2 cell line[J].Inflammation,2012,35(4):1487-99.  

[21] CHON H,CHOI B,JEONG G,et al.Suppression of proinflammatory cytokine production by specific metabolites of Lactobacillus plantarum 10hk2 via inhibiting NF-kappaB and p38 MAPK expressions[J].Comparative Immunology,Microbiology and Infectious Diseases,2010,33(6):e41-49.  

[22] MENARD S,CANDALH C,BAMBOU J C,et al.Lactic acid bacteria secrete metabolites retaining anti-inflammatory properties after intestinal transport[J].Gut,2004,53(6):821-828.  
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