Regulation of Milk Protein Synthesis by Energy and Essential Amino Acids through Adenosine 5'-Monophosphate-Activated Protein Kinase/Mammalian Target Rapamycin Signaling Pathway

WANG Shanshan; WANG Jiaqi; GAO Haina; YAN Sumei; ZHENG Nan

doi:10.3969/j.issn.1006-267x.2015.08.005

2015 , Vol. 27 >Issue 8: 2342 - 2348

DOI: https://doi.org/10.3969/j.issn.1006-267x.2015.08.005

Molecular Nutrition

Regulation of Milk Protein Synthesis by Energy and Essential Amino Acids through Adenosine 5'-Monophosphate-Activated Protein Kinase/Mammalian Target Rapamycin Signaling Pathway

WANG Shanshan ,
WANG Jiaqi ,
GAO Haina ,
YAN Sumei ,
ZHENG Nan

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1. Ministry of Agriculture-Milk Risk Assessment Laboratory, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
2. College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China;
3. Ministry of Agriculture-Milk and Dairy Product Inspection Center, Beijing 100193, China;
4. State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
5. College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China

Received date: 2015-03-17

Online published: 2015-08-13

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Abstract

Milk protein synthesis is a process that consumes essential amino acids (EAA) and energy. Adenosine 5'-monophosphate-activated protein kinase (AMPK) is an important molecule in AMPK signaling pathway, which can maintain its energy balance through the way of feeling cellular energy state with the aim of providing sufficient energy for milk protein synthesis. Mammalian target rapamycin (mTOR) is an important downstream target in AMPK signaling pathway by that EAA mainly mediated milk protein synthesis. This review summarized regulatory roles of energy and EAA through AMPK/mTOR signaling pathway in process of milk protein synthesis.

Key words： AMPK; mTOR; EAA; energy; milk protein

Cite this article

WANG Shanshan , WANG Jiaqi , GAO Haina , YAN Sumei , ZHENG Nan . Regulation of Milk Protein Synthesis by Energy and Essential Amino Acids through Adenosine 5'-Monophosphate-Activated Protein Kinase/Mammalian Target Rapamycin Signaling Pathway[J]. Chinese Journal of Animal Nutrition, 2015 , 27(8) : 2342 -2348 . DOI: 10.3969/j.issn.1006-267x.2015.08.005

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