Maternal Undernutrition during Late Pregnancy: Effects on Lipid Metabolism in Fetal Liver of Mongolia Ovine

LI Lingyao; GAO Feng; HE Shan; MA Rongrong; LIU Yingchun

doi:10.3969/j.issn.1006-267x.2015.09.011

Chinese Journal of Animal Nutrition >

2015 , Vol. 27 >Issue 9: 2736 - 2741

DOI: https://doi.org/10.3969/j.issn.1006-267x.2015.09.011

Ruminant Nutrition

Maternal Undernutrition during Late Pregnancy: Effects on Lipid Metabolism in Fetal Liver of Mongolia Ovine

LI Lingyao ,
GAO Feng ,
HE Shan ,
MA Rongrong ,
LIU Yingchun

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1. College of Animal Science, Inner Mongolian Agricultural University, Hohhot 010018, China;
2. College of Life Science, Inner Mongolian Agricultural University, Hohhot 010018, China;
3. Inner Mongolia Key Laboratory of Bio-Manufacturing, Hohhot 010018, China

Received date: 2015-03-10

Online published: 2015-09-12

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Abstract

This study aimed to investigate the effects of intrauterine growth restriction (IUGR) during late pregnancy on lipid metabolism in fetal liver of Mongolia ovine. Twenty four healthy Mongolian ewes in second or third parities with similar body weight at synchronization of estrus and superfecundation were selected. Six ewes were slaughtered at the beginning of the experiment (90 d of gestation) and the remaining animals were allocated to three different groups: 0.175 MJ/(kg BW^0.75·d) group (RG1 group), 0.33 MJ/(kg BW^0.75·d) group (RG2 group) and 0.67 MJ/(kg BW^0.75·d) group [ad libitum group (CG group)], each group had six ewes. At 140 d of gestation, ewes were slaughtered and liver and plasma of their fetuses were collected. The results showed as follows: at 140 d of gestation, compared with GC group, the fetal liver weight (P<0.01), the mass of dry matter (P<0.01), ether extract (P<0.05), crude protein (P<0.01), ash (P<0.05) and moisture (P<0.01), the contents of triglycerides (P<0.01) and total cholesterol (P<0.01), and the activities of lipoprotein lipase (P<0.01) and hepatic lipase (P<0.05) in fetal liver as well as triglycerides content (P<0.05) in fetal plasma were significantly or extremely significantly decreased, meanwhile, the contents of β-hydroxybutyrate (P<0.01), nonesterified fatty acid (P<0.05), total cholesterol (P<0.05) in fetal plasma were significantly or extremely significantly enhanced in RG1 group; fetal liver weight (P<0.05), moisture mass (P<0.01) and lipoprotein lipase activity (P<0.01) in fetal liver and triglycerides content (P<0.05) in fetal plasma were significantly or extremely significantly decreased. In conclusion, the growth and development of fetal liver are affected seriously by IUGR during late pregnancy, and the capability of fetal lipid synthesis is decreased, the activities of lipoprotein lipase and hepatic lipase in fetal liver are decreased, and lipid metabolite contents in fetal plasma are greatly enhanced.

Key words： IUGR; fetal liver; growth and development; lipid metabolism

Cite this article

LI Lingyao , GAO Feng , HE Shan , MA Rongrong , LIU Yingchun . Maternal Undernutrition during Late Pregnancy: Effects on Lipid Metabolism in Fetal Liver of Mongolia Ovine[J]. Chinese Journal of Animal Nutrition, 2015 , 27(9) : 2736 -2741 . DOI: 10.3969/j.issn.1006-267x.2015.09.011

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