Synergy Effects of Low Dietary Cation-Anion Difference with Vitamin D on Plasma Concentrations of Calcium and Its Modulators of Pregnant Goats

ZHU Lunqin; TIAN Xingzhou; YUAN Xin; YANG Chunhong; XIN Hailiang; ZHAO Wenjin; WU Wenxuan

doi:10.3969/j.issn.1006-267x.2015.09.012

2015 , Vol. 27 >Issue 9: 2742 - 2748

DOI: https://doi.org/10.3969/j.issn.1006-267x.2015.09.012

Ruminant Nutrition

Synergy Effects of Low Dietary Cation-Anion Difference with Vitamin D on Plasma Concentrations of Calcium and Its Modulators of Pregnant Goats

ZHU Lunqin ,
TIAN Xingzhou ,
YUAN Xin ,
YANG Chunhong ,
XIN Hailiang ,
ZHAO Wenjin ,
WU Wenxuan

Expand

1. College of Animal Science, Guizhou University, Guiyang 550025, China;
2. Qiandongnan National Polytechnic, Kaili 556000, China;
3. Fuxing Husbandry Co., Ltd., Xishui County, Xishui 564600, China;
4. Institute of New Rural Development·China Center for Western Development Capacity Research, Guizhou University, Guiyang 550025, China

Received date: 2015-03-26

Online published: 2015-09-12

Fold

Abstract

This study was conducted to evaluate the synergy effects of low dietary cation-anion difference (DCAD) with vitamin D on plasma concentrations of calcium (Ca) and its modulators of pregnant goats. Eighteen healthy pregnant goats were randomly allocated to 3 blocks with 6 replicates per group and 1 goat per replicate. Goats were fed 3 DCAD at 212.4 (control), -145.5 (Ⅰ), -145.5 mmol/kg (Ⅱ) [dry matter (DM) basis, measured values], respectively. Control group was fed a basal diet, 45 g/d MgCl₂·6H₂O was added in group Ⅰ on the basis of the basal diet, and 2 000 IU/d vitamin D was added in group Ⅱ on the basis of group Ⅰ. The pre-test lasted for 10 d, and the test lasted for 30 d. The results showed as follow: 1) urine pH was significantly reduced in groups Ⅰ and Ⅱ over control (P<0.05). For the growth performance measurements DM intake, average daily gain, and feed to gain ratio were not affected by dietary treatments (P>0.05). 2) Compared with control group, plasma Ca concentration was increased in groups Ⅰ (P>0.05) and Ⅱ (P<0.05); there were no significant differences in plasma phosphorus, parathormone and calcitonin concentrations for control group and groups Ⅰ and Ⅱ (P>0.05), but group Ⅱ significantly increased plasma 1,25-(OH)₂VD₃ concentration compared with control group and group Ⅰ (P<0.05). 3) Plasma vitamin D receptor and Ca-binding protein-D9k concentrations in group Ⅱ were significantly increased compared with control group (P<0.05). These results suggest that blood Ca homeostasis can be more available to maintain by low DCAD synergized with vitamin D under the conditions in the present study.

Key words： dietary cation-anion difference; vitamin D receptor; Ca-binding protein-D9k; plasma Ca concentration

Cite this article

ZHU Lunqin , TIAN Xingzhou , YUAN Xin , YANG Chunhong , XIN Hailiang , ZHAO Wenjin , WU Wenxuan . Synergy Effects of Low Dietary Cation-Anion Difference with Vitamin D on Plasma Concentrations of Calcium and Its Modulators of Pregnant Goats[J]. Chinese Journal of Animal Nutrition, 2015 , 27(9) : 2742 -2748 . DOI: 10.3969/j.issn.1006-267x.2015.09.012

References

[1] KOEPPEN B M,STANTON B A.Berne & levy physiology[M].Amsterdam:Mosby Elsevier,2008.

[2] GOFF J P.Macromineral physiology and application to the feeding of the dairy cow for prevention of milk fever and other periparturient mineral disorders[J].Animal Feed Science and Technology,2006,126(3/4):237-257.

[3] THILSING-HANSEN T,JØRGENSEN R J,ØSTERGAARD S.Milk fever control principles:a review[J].Acta Veterinaria Scandinavica,2002,43(1):1-19.

[4] WILKENS M R,MROCHEN N,BREVES G,et al.Gastrointestinal calcium absorption in sheep is mostly insensitive to an alimentary induced challenge of calcium homeostasis[J].Comparative Biochemistry and Physiology Part B:biochemistry and molecular biology,2011,158(3):199-207.

[5] BRONNER F.Recent developments in intestinal calcium absorption[J].Nutrition Reviews,2009,67(2):109-113.

[6] NELSON C D,MERRIMAN K E.Vitamin D metabolism in dairy cattle and implications for dietary requirements[C]//25th Annual Florida Ruminant Nutrition Symposium.Gainesville, FL:University of Florida IFAS Extension,2014:78-91.

[7] HAUSSLER M R,WHIRFIELD G K,KANEKO I,et al.Molecular mechanisms of vitamin D action[J].Calcified Tissue International,2013,92(2):77-98.

[8] 莘海亮.日粮阴阳离子差调控动物胃肠道维生素D受体调控作用的研究[D].硕士学位论文.贵阳:贵州大学,2014.

[9] WU W X,YI Y,ZHANG J K,et al.Reducing dietary cation-anion difference on acid-base balance,plasma minerals level and anti-oxidative stress of female goats[J].Journal of Integrative Agriculture,2013,12(9):1620-1628.

[10] STEWART P A.Modern quantitative acid-base chemistry[J].Canadian Journal of Physiology and Pharmacology,1983,61(12):1444-1461.

[11] 陈娟.钙和维生素D对肉仔鸡生长性能、屠宰性能和肉品质的影响[D].硕士学位论文.哈尔滨:东北农业大学,2011.

[12] GOFF J P,LIESEGANG A,HORST R L.Diet-induced pseudohypoparathyroidism:a hypocalcemia and milk fever risk factor[J].Journal of Dairy Science,2014,97(3):1520-1528.

[13] SAKHA M,MAHMOUDI M,NADALIAN M G.Effects of dietary cation-anion difference on milk fever,subclinical hypocalcemia and negative energy balance in transition dairy cows[J].Research Opinions in Animal and Veterinary Sciences,2014,4(2):69-73.

[14] 郑家三,夏成,王琳琳,等.过瘤胃维生素D对围产期奶牛低血钙症的影响[J].中国畜牧兽医,2013,40(8):57-60.

[15] GOFF J P.Calcium and magnesium disorders[J].Veterinary Clinics of North America:Food Animal Practice,2014,30(2):359-381.

[16] WILKENS M R,OBERHEIDE I,SCHRÖDER B,et al.Influence of the combination of 25-hydroxyvitamin D₃ and a diet negative in cation-anion difference on peripartal calcium homeostasis of dairy cows[J].Journal of Dairy Science,2012,95(1):151-164.

[17] OVERTON T R,WALDRON M R.Nutritional management of transition dairy cows:strategies to optimize metabolic health[J].Journal of Dairy Science,2004,87:E105-E119.

[18] PATEL V R,KANSARA J D,PATEL B B,et al.Prevention of milk fever:nutritional approach[J].Veterinary World,2011,4(6):278-280.

[19] OEHLSCHLAEGER V,WILKENS M,SCHROEDER B,et al.Effects of 25-hydroxyvitamin D₃ on localisation and extent of gastrointestinal calcium absorption in dairy cattle[J].Animal Production Science,2014,54(9):1394-1398.

[20] WANG Y J,ZHU J G,DELUCA H F.Where is the vitamin D receptor?[J].Archives of Biochemistry and Biophysics,2012,523(1):123-133.

[21] XUE Y B,FLEET J C.Intestinal vitamin D receptor is required for normal calcium and bone metabolism in mice[J].Gastroenterology,2009,136(4):1317-1327.

[22] KOGAWA M,FINDLAY D M,ANDERSON P H,et al.Osteoclastic metabolism of 25 (OH)-vitamin D₃:a potential mechanism for optimization of bone resorption[J].Endocrinology,2010,151(10):4613-4625.

[23] MARTÍN-TERESO J,VERSTEGEN M W A.A novel model to explain dietary factors affecting hypocalcaemia in dairy cattle[J].Nutrition Research Reviews,2011,24(2):228-243.

Options

Outlines

模态框（Modal）标题

Abstract

Cite this article

References