Sodium Dependent Neutral Amino Acid Transporter 2: Characteristics, Expression Regulation and Function

LI Guangran; TAN Bi; GUAN Guiping; YIN Yulong

doi:10.3969/j.issn.1006-267x.2015.11.004

Chinese Journal of Animal Nutrition >

2015 , Vol. 27 >Issue 11: 3338 - 3344

DOI: https://doi.org/10.3969/j.issn.1006-267x.2015.11.004

REVIEW

Sodium Dependent Neutral Amino Acid Transporter 2: Characteristics, Expression Regulation and Function

LI Guangran ,
TAN Bi ,
GUAN Guiping ,
YIN Yulong

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1. Observation and Experiment Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;
2. University of Chinese Academy of Sciences, Beijing 100049, China;
3. College of Biology and Technology, Hunan Agricultural University, Changsha 410128, China

Received date: 2015-05-14

Online published: 2015-11-21

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Abstract

Sodium-dependent neutral amino acid transporter 2 (SNAT2), which belongs to transport system A,is the main transporter of nitrogen in vivo. SNAT2 is well known as typical amino acid transceptor founded in recent years, which plays a dual role of amino acid transporter and receptor through regulating the concentration of intracellular amino acids, thereby regulating the downstream signal of intracellular amino acid receptors. Because of its unique features, SNAT2 has become an attractive topic in nutritional induction of amino acids in recent years. In the present review, the new research progresses on the molecular characteristics, biological properties, expression regulation and amino acids sensing signaling of SNAT2 were summarized.

Key words： sodium-dependent neutral amino acid transporter 2; molecular characteristic; expression regulation; mTOR signaling pathway

Cite this article

LI Guangran , TAN Bi , GUAN Guiping , YIN Yulong . Sodium Dependent Neutral Amino Acid Transporter 2: Characteristics, Expression Regulation and Function[J]. Chinese Journal of Animal Nutrition, 2015 , 27(11) : 3338 -3344 . DOI: 10.3969/j.issn.1006-267x.2015.11.004

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