[1] WHITING T L, PASMA T.Isolated weaning technology:humane benefits and concerns in the production of pork[J].The Canadian Veterinary Journal, 2008, 49(3):293-301.
[2] CHEUNG Q C, YUAN Z F, DYCE P W, et al.Generation of epidermal growth factor-expressing Lactococcus lactis and its enhancement on intestinal development and growth of early-weaned mice[J].American Journal of Clinical Nutrition, 2009, 89(3):871-879.

[3] WANG S J, ZHOU L, CHEN H N, et al.Analysis of the biological activities of Saccharomyces cerevisiae expressing intracellular EGF, extracellular EGF, and tagged EGF in early-weaned rats[J].Applied Microbiology and Biotechnology, 2015, 99(5):2179-2189.

[4] CELLINI C, XU J, BUCHMILIER-CRAIR T.Effect of epidermal growth factor on small intestinal sodium/glucose cotransporter-1 expression in a rabbit model of intrauterine growth retardation[J].Journal of Pediatric Surgery, 2005, 40(12):1892-1897.

[5] KANG P, TOMS D, YIN Y L, et al.Epidermal growth factor-expressing Lactococcus lactis enhances intestinal development of early-weaned pigs[J].The Journal of Nutrition, 2010, 140(4):806-811.

[6] WANG S J, GUO C H, ZHOU L, et al.Comparison of the biological activities of Saccharomyces cerevisiae-expressed intracellular EGF, extracellular EGF, and tagged EGF in early-weaned pigs[J].Applied Microbiology and Biotechnology, 2015, doi:10.1007/s00253-015-6468-6.
[7] BEDFORD A, HUYNH E, FU M L, et al.Growth performance of early-weaned pigs is enhanced by feeding epidermal growth factor-expressing Lactococcus lactis fermentation product[J].Journal of Biotechnology, 2014, 173:47-52.
[8] BEDFORD A, LI Z, LI M, et al.Epidermal growth factor-expressing Lactococcus lactis enhances growth performance of early-weaned pigs fed diets devoid of blood plasma[J].Journal of Animal Science, 2012, 90(4S):4-6.
[9] 王勇飞, 段叶辉, 夏连喜, 等.重组猪表皮生长因子对早期断奶仔猪生长性能的影响[J].动物营养学报, 2014, 26(12):3787-3792.
[10] LEE D N, CHANG W F, YU I T, et al.Effects of diets supplemented with recombinant epidermal growth factor and glutamine on gastrointestinal tract development of early-weaned piglets[J].Asian-Australasian Journal of Animal Sciences, 2008, 21(4):582-589.

[11] BEDFORD A, CHEN T, HUYNH E, et al.Epidermal growth factor containing culture supernatant enhances intestine development of early-weaned pigs in vivo:potential mechanisms involved[J].Journal of Biotechnology, 2015, 196-197:9-19.
[12] LEE D N, CHUANG Y S, CHIOU H Y, et al.Oral administration recombinant porcine epidermal growth factor enhances the jejunal digestive enzyme genes expression and activity of early-weaned piglets[J].Journal of Animal Physiology and Animal Nutrition, 2008, 92(4):463-470.

[13] SCHNEIDER M R, WOLF E.The epidermal growth factor receptor ligands at a glance[J].Journal of Cellular Physiology, 2009, 218(3):460-466.

[14] COHEN S.Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal[J].The Journal of Biological Chemistry, 1962, 237:1555-1562.
[15] ZENG H F, HARRIS R C.Epidermal growth factor, from gene organization to bedside[J].Seminars in Cell & Developmental Biology, 2014, 28:2-11.
[16] 刘淑杰, 徐子伟, 齐珂珂, 等.表皮生长因子对肠道功能调控的研究[J].动物营养学报, 2014, 26(3):565-570.
[17] CAMPBELL J M, CRENSHAW J D, POLO J.The biological stress of early weaned piglets[J].Journal of Animal Science and Biotechnology, 2013, 4:19.
[18] 槐玉英, 纪少丽, 李明, 等.表达表皮生长因子的乳酸球菌对早期断奶仔猪生长性能和肠道形态学结构的影响[J].中国兽医杂志, 2013, 49(3):21-23.
[19] WANG D Y, XU S Y, LIN Y, et al.Recombinant porcine epidermal growth factor-secreting Lactococcus lactis promotes the growth performance of early-weaned piglets[J].BMC Veterinary Research, 2014, 10:171.
[20] ABDULL RAZIS A F, ISMAIL E N, HAMBALI Z, et al.Expression of recombinant human epidermal growth factor in Escherichia coli and characterization of its biological activity[J].Applied Biochemistry and Biotechnology, 2008, 144(3):249-261.

[21] LEE D N, KUO T Y, CHEN M C, et al.Expression of porcine epidermal growth factor in Pichia pastoris and its biology activity in early-weaned piglets[J].Life Sciences, 2006, 78(6):649-654.

[22] 王蜀金, 周琳, 陈慧娜, 等.重组猪表皮生长因子在酿酒酵母中的克隆表达及其生物学活性鉴定[J].畜牧兽医学报, 2014, 45(12):1971-1980.
[23] XU S, WANG D, ZHANG P, et al.Oral administration of Lactococcus lactis-expressed recombinant porcine epidermal growth factor stimulates the development and promotes the health of small intestines in early-weaned piglets[J].Journal of Applied Microbiology, 2015, 119(1):225-235.

[24] ZHELEZNOVA N N, WILSON P D, STARUSCHENKO A.Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells[J].Biochimica et Biophysica Acta:Molecular Basis of Disease, 2011, 1812(10):1301-1313.

[25] O'MAHONY F, TOUMI F, MROZ M S, et al.Induction of Na
+/K
+/2Cl
- cotransporter expression mediates chronic potentiation of intestinal epithelial Cl
- secretion by EGF[J].American Journal of Physiology Cell Physiology, 2008, 294(6):C1362-C1370.
[26] MROZ M S, KEELY S J.Epidermal growth factor chronically upregulates Ca
2+-dependent Cl
- conductance and TMEM16A expression in intestinal epithelial cells[J].The Journal of Physiology, 2012, 590(8):1907-1920.

[27] TRINH N T, PRIVE A, MAILLE E, et al.EGF and K
+ channel activity control normal and cystic fibrosis bronchial epithelia repair[J].American Journal of Physiology Lung Cellular and Molecular Physiology, 2008, 295(5):L866-L880.
[28] BEZZERIDES V J, RAMSEY I S, KOTECHA S, et al.Rapid vesicular translocation and insertion of TRP channels[J].Nature Cell Biology, 2004, 6(8):709-720.

[29] XU H, INOUYE M, HINES E R, et al.Transcriptional regulation of the human NaP
i-Ⅱb cotransporter by EGF in Caco-2 cells involves c-myb[J].American Journal of Physiology Cell Physiology, 2003, 284(5):C1262-C1271.
[30] YANG C B, ALBIN D M, WANG Z R, et al.Apical Na
+-d-glucose cotransporter 1(SGLT1) activity and protein abundance are expressed along the jejunal crypt-villus axis in the neonatal pig[J].American Journal of Physiology:Gastrointestinal and Liver Physiology, 2011, 300(1):G60-G70.
[31] RAY E C, AVISSAR N E, SALLOUM R, et al.Growth hormone and epidermal growth factor upregulate specific sodium-dependent glutamine uptake systems in human intestinal C2BBe1 cells[J].The Journal of Nutrition, 2005, 135(1):14-18.
[32] CELLINI C, XU J, ARRIAGA A, et al.Effect of epidermal growth factor infusion on fetal rabbit intrauterine growth retardation and small intestinal development[J].Journal of Pediatric Surger, 2004:39(6):891-897.
[33] PAULSEN F P, WOON C W, VAROGA D, et al.Intestinal trefoil factor/TFF3 promotes re-epithelialization of corneal wounds[J].The Journal of Biological Chemistry, 2008, 283(19):13418-13427.

[34] HUYNH E, LI J L.Generation of Lactococcus lactis capable of coexpressing epidermal growth factor and trefoil factor to enhance in vitro wound healing[J].Applied Microbiology and Biotechnology, 2015, 99(11):4667-4677.

[35] MANNON P, REINISCH W.Interleukin 13 and its role in gut defence and inflammation[J].Gut, 2012, 61(12):1765-1773.

[36] JUNG K, KANG B K, KIM J Y, et al.Effects of epidermal growth factor on atrophic enteritis in piglets induced by experimental porcine epidemic diarrhoea virus[J].The Veterinary Journal, 2008, 177(2):231-235.

[37] BRAND T M, LIDA M, LI C, et al.The nuclear epidermal growth factor receptor signaling network and its role in cancer[J].Discovery Medicine, 2011, 12(66):419-432.
[38] WANG C W, CHANG W L, HUANG Y C, et al.An essential role of cAMP response element-binding protein in epidermal growth factor-mediated induction of sodium/glucose cotransporter 1 gene expression and intestinal glucose uptake[J].The International Journal of Biochemistry & Cell Biology, 2015, 64:239-251.