REVIEW

Research of β-Adrenoceptor Agonists Residues in Foodstuffs of Animal Origin

  • LI Jun ,
  • GU Liqun ,
  • WANG Mingjin ,
  • XIONG Huoqin ,
  • HE Hu ,
  • LI Lei ,
  • LI Xuanmin
Expand
  • Bijie Animal Products Quality Security Supervision and Inspection Center, Bijie 551700, China

Received date: 2015-07-02

  Online published: 2015-12-14

Abstract

β-adrenoceptor agonists(β-agonists for short) possess the capacity to regulate nutrient metabolism in an animal body, such as decreasing fat content, promoting protein synthesis and increasing feed efficiency. A lot of profit-oriented illegal users often use it as feed additive for animal products, but its residues in animal products eventually enter human body through food chain, which may pose potential risks to human health, so many countries have passed a series of laws and regulations to prohibit the use of β-agonists in animal husbandry. This article reviewed the mechanisms of action, standards and methods of detection of β-agonists, which would provide the reference in the study of β-agonists residues.

Cite this article

LI Jun , GU Liqun , WANG Mingjin , XIONG Huoqin , HE Hu , LI Lei , LI Xuanmin . Research of β-Adrenoceptor Agonists Residues in Foodstuffs of Animal Origin[J]. Chinese Journal of Animal Nutrition, 2015 , 27(12) : 3663 -3670 . DOI: 10.3969/j.issn.1006-267x.2015.12.003

References

[1] 翟福丽,赖克强,张衍亮,等.动物性食品中β-兴奋剂残留概述[J].食品科学,2011,32(5):351-356.
[2] 王若军,郭年藩.β-肾上腺素能兴奋剂的作用机理及应用效果(上)[J].国外畜牧科技,1993,20(6):20-21.
[3] 许青华.沙丁胺醇药物残留酶联免疫检测法的建立[D].硕士学位论文.广州:华南理工大学,2012.
[4] EASSON L H,STEDMAN E.Studies on the relationship between chemical constitution and physiological action:molecular dissymmetry and physiological activity[J].Biochemical Journal,1933,27(4):1257-1266.  
[5] SALPETER S R,BUCKLEY N S,ORMISTON T M,et al.Meta-analysis:effect of long-acting β-agonists on severe asthma exacerbations and asthma-related deaths[J].Annals of internal medicine,2006,144(12):904-912.  
[6] BAKER P K,KIERNAN J A.Phenylethanolamine derivatives and acid addition salts thereof for enhancing the growth rate of meat-producing animals and improving the efficiency of feed utilization thereby[P].United States Patent 4404222,1983-09-13.
[7] BAKER P K,DALRYMPLE R H,INGLE D L,et al.Use of a β-adrenergic agonist to alter muscle and fat deposition in lambs[J].Journal of Animal Science,1984,59(5):1256-1261.
[8] VANOOSTHUYZE K E I,ARTS C J M,VAN PETEGHEM C H.Development of a fast and simple method for determination of β-agonists in urine by extraction on empore membranes and detection by a test strip immunoassay[J].Journal of Agricultural and Food Chemistry,1997,45(8):3129-3137.  
[9] SHELVER W L,SMITH D J.Determination of ractopamine in cattle and sheep urine samples using an optical biosensor analysis:comparative study with HPLC and ELISA[J].Journal of Agricultural and Food Chemistry,2003,51(13):3715-3721.  
[10] SMITH D J.The pharmacokinetics,metabolism,and tissue residues of beta-adrenergic agonists in livestock[J].Journal of Animal Science,1998,76(1):173-194.
[11] 汪慧蓉.β-兴奋剂克伦特罗、沙丁胺醇的免疫检测方法研究[D].硕士学位论文.西安.西北大学,2006.
[12] 王选年.β-肾上腺素受体激动剂克伦特罗的免疫特性及中毒病理学研究[D].博士学位论文.长春:中国人民解放军军需大学,2002.
[13] 段铭,高宏伟,梁鸿雁.β-肾上腺素受体兴奋剂的作用机制及药学特性的研究进展[J].黑龙江八一农垦大学学报,2001,13(2):76-81.
[14] ARCH J R S,KAUMANN A J.β3 and atypical β-adrenoceptors[J].Medicinal Research Reviews,1993,13(6):663-729.  
[15] PIÉTRI-ROUXEL F,LENZEN G,KAPOOR A,et al.Molecular cloning and pharmacological characterization of the bovine β3-adrenergic receptor[J].European Journal of Biochemistry,1995,230(1):350-358.  
[16] MERSMANN H J.Overview of the effects of beta-adrenergic receptor agonists on animal growth including mechanisms of action[J].Journal of Animal Science,1998,76(1):160-172.
[17] 陈刚,周光宏.β-肾上腺素能激动剂作用机理及对生长代谢的影响[J].青海畜牧兽医杂志,1998,28(4):38-39.
[18] 农业部.农牧发第17号.关于发布《动物性食品中兽药最高残留限量》的通知[EB/OL].1999.http://www.moa.gov.cn/ztzl/xumugb/99-2-2.htm
[19] 中华人民共和国农业部.农业部958号公告-3-2007 动物源食品中莱克多巴胺残留量的测定-高效液相色谱法-质谱法[OL].北京:中国标准出版社,2007.
[20] 中华人民共和国农业部.农业部1025号公告-18-2008 动物源性食品中β-受体激动剂残留检测液相色谱-串联质谱法[OL].北京:中国农业出版社,2008.
[21] 中华人民共和国农业部.农业部1063号公告-3-2008 动物尿液中11种β-受体激动剂的检测液相色谱-串联质谱法[OL].北京:中国标准出版社,2008.
[22] 中华人民共和国农业部.农业部1629号公告-1-2011 饲料中16种β-受体激动剂的检测 液相色谱-串联质谱法[OL].北京:中国农业出版社,2011,
[23] 赵晓风,徐雪华,万宇平,等.β2-兴奋剂类药物残留检测的研究进展[J].四川畜牧兽医,2011,38(7):29-30,33.
[24] 赵亚华.动物性食品中β2-受体激动剂残留检测技术的研究概况[J].中国卫生检验杂志,2003,13(3):387-390.
[25] 张慧嫦,张少恩,吴忠华,等.胶体金免疫层析法快速检测盐酸克伦特罗残留[J].中国国境卫生检疫杂志,2008,31(1):39-42.
[26] 姜金庆,杨雪峰,王自良,等.克伦特罗和莱克多巴胺多残留胶体金免疫层析试纸条的研制[J].畜牧兽医学报,2013,44(1):87-94.
[27] 何明祥.沙丁胺醇时间分辨荧光免疫分析检测技术的研究[J].长江大学学报:自然科学版,2009,6(1):33-37.
[28] 武学成,何林,周克元.时间分辨荧光免疫分析技术及临床应用[J].医学综述,2006,12(7):434-436.
[29] 杭建峰,吴英松,李明.时间分辨荧光免疫分析的研究进展及应用[J].热带医学杂志,2004,4(3):340-343,304.
[30] 徐汉琴.毛细管电泳免疫分析综述[J].中国医学研究与临床,2006,4(4):27-30.
[31] TRAYNOR I M,CROOKS S R H,BOWERS J,et al.Detection of multi-β-agonist residues in liver matrix by use of a surface plasma resonance biosensor[J].Analytica Chimica Acta,2003,483(1/2):187-191.
[32] LU X,ZHENG H,LI X Q,et al.Detection of ractopamine residues in pork by surface plasmon resonance-based biosensor inhibition immunoassay[J].Food Chemistry,2012,130(4):1061-1065.  
[33] 陶亮亮,寇庆,梁咪娟.饲料中β-兴奋剂检测方法的研究进展[J].中国饲料,2011(21):6-8.
[34] KNECHT B G,STRASSER A,DIETRICH R,et al.Automated microarray system for the simultaneous detection of antibiotics in milk[J].Analytical Chemistry,2004,76(3):646-654.  
[35] 李琴,姜金斗,姜全忠,等.生物芯片技术用于同时测定乳与乳粉中β-兴奋剂类残留量[J].中国乳品工业,2014,42(2):52-54,64.
Outlines

/