Molecular Nutrition

Toll-Like Receptors and Their Regulation Role of Intestinal Mucosal Immunity

  • QUAN Jiahui ,
  • JIANG Ning ,
  • ZHANG Aizhong ,
  • HUANG Fujia ,
  • JIANG Dianhui ,
  • SONG Lei ,
  • ZHANG Weiqing
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  • College of Animal Science, Heilongjiang Bayi Agricultural University, Daqing 163319, China

Received date: 2015-07-18

  Online published: 2016-01-22

Abstract

Toll-like receptors (TLRs) are a highly conservative group of pattern recognition receptors, which play roles of pathogen sensors in vertebrate and invertebrate species. Recently, Toll-like receptors have been far and wide concerned. The recognition of TLRs to specific ligands is the basis of the innate immune system, and it enables protective responses to mount rapidly, then, it can activate adaptive immunity against invading pathogens. TLRs play an important role in the process of distinguishing between the pathogenic bacteria and probiotic for the intestinal immune, while secretion of antimicrobial peptides is also regulated by TLRs in intestinal epithelial. This paper introduced the types of TLRs, ligands and the corresponding signal pathway, and discussed the key role of TLRs in intestinal immune regulation.

Cite this article

QUAN Jiahui , JIANG Ning , ZHANG Aizhong , HUANG Fujia , JIANG Dianhui , SONG Lei , ZHANG Weiqing . Toll-Like Receptors and Their Regulation Role of Intestinal Mucosal Immunity[J]. Chinese Journal of Animal Nutrition, 2016 , 28(1) : 43 -49 . DOI: 10.3969/j.issn.1006-267x.2016.01.007

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