Molecular Nutrition

Energy Sensing Network AMPK/SIRT1/PGC-lα Involved in Regulating Skeletal Muscle Fiber Type Transformation

  • WEN Chaoyue ,
  • DUAN Yehui ,
  • LI Yinghui ,
  • GUO Qiuping ,
  • KONG Xiangfeng ,
  • LI Fengna
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  • 1. College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China;
    2. Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;
    3. University of Chinese Academy of Sciences, Beijing 100049, China

Received date: 2015-07-24

  Online published: 2016-01-22

Abstract

AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) and silent information regulator 1 (SIRT1) act as an orchestrated network to regulate the signal of cellular energy output, that is called energy sensing, to modulate energy metabolism, mitochondria and muscle fiber transformation of the whole body. This review extracted the new advances and summarized the critical roles of the AMPK/PGC-1α/SIRT1 energy network in regulating muscle fiber transformation, so as to provide references for livestock production and human nutrition.

Cite this article

WEN Chaoyue , DUAN Yehui , LI Yinghui , GUO Qiuping , KONG Xiangfeng , LI Fengna . Energy Sensing Network AMPK/SIRT1/PGC-lα Involved in Regulating Skeletal Muscle Fiber Type Transformation[J]. Chinese Journal of Animal Nutrition, 2016 , 28(1) : 57 -63 . DOI: 10.3969/j.issn.1006-267x.2016.01.009

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