This experiment was conducted to study the effects of dietary manganese (Mn) level on growth performance and serum biochemical indices of growing minks. Seventy-five 60-day-old healthy male minks were randomly divided into 5 groups with 15 replicates per group and 1 mink per replicate. Minks in the 5 groups were fed the experimental diets supplemented with 0 (group Ⅰ, as control group), 50 (group Ⅱ), 100 (group Ⅲ), 300 (group Ⅳ) and 600 mg/kg (group Ⅴ) Mn based on a basal diet, respectively, and the Mn level in the basal diet was 43.69 mg/kg. There was a 7-day adaptation period and a 60-day experimental period. The results showed as follows: the average daily feed intake was not significantly different among all groups (P>0.05). There was no significant difference in average body weight among all groups at 60, 75, 90 and 105 days of age (P>0.05), but the highest value of average body weight at the 120 days of age was found in group Ⅳ, and it was significantly higher than that in group Ⅰ (P<0.05). The average daily gain (ADG) in group Ⅳ was significantly higher than that in other groups during 60 to 75, 91 to 105 and 106 to 120 days of age (P<0.05). Dietary Mn level had no significant effects on serum total protein (TP), albumin (ALB), globulin (GLOB), immunoglobulin A (IgA) and immunoglobulin M (IgM) contents and serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP) activities, and all of them in group Ⅳ had the highest values. The serum urea nitrogen (UN) content in group Ⅳ was significantly lower than that in other groups (P<0.05). The serum lactic acid dehydrogenase (LDH), total superoxide dismutase (T-SOD), Mn-superoxide dismutase (Mn-SOD) activities and serum immunoglobulin G (IgG) content were not significantly different among all groups (P>0.05). Under the conditions of this experiment, dietary supplemented with 300 mg/kg Mn and the dietary Mn level is 343.69 mg/kg can improve the growth performance of growing mink, it also can improve protein metabolism related index contents, Mn related enzyme activities, and the immunity of mink.
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