[1] BOSTRÖM P,WU J,JEDRYCHOWSKI M P,et al.A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis[J].Nature,2012,481(7382):463-468.
[2] FERRER-MARTÍNEZ A,RUIZ-LOZANO P,CHIEN K R.Mouse PeP:a novel peroxisomal protein linked to myoblast differentiation and development[J].Developmental Dynamics,2002,224(2):154-167.
[3] TEUFEL A,MALIK N,MUKHOPADHYAY M,et al.
Frcp1 and
Frcp2,two novel fibronectin type Ⅲ repeat containing genes[J].Gene,2002,297(1/2):79-83.
[4] 周伟,陈俊.运动与PGC-1α依赖性肌肉因子鸢尾素研究进展[J].中国运动医学杂志,2014,33(7):746-752.
[5] ERICKSON H P.Irisin and FNDC5 in retrospect:an exercise hormone or a transmembrane receptor?[J].Adipocyte,2013,2(4):289-293.
[6] HUH J Y,PANAGIOTOU G,MOUGIOS V,et al.FNDC5 and irisin in humans: Ⅰ.Predictors of circulating concentrations in serum and plasma and Ⅱ.mRNA expression and circulating concentrations in response to weight loss and exercise[J].Metabolism,2012,61(12):1725-1738.
[7] HOFMANN T,ELBELT U,STENGEL A.Irisin as a muscle-derived hormone stimulating thermogenesis-A critical update[J].Peptides,2014,54:89-100.
[8] KULOGLU T,AYDIN S,EREN M N,et al.Irisin:a potentially candidate marker for myocardial infarction[J].Peptides,2014,55:85-91.
[9] ROCA-RIVADA A,CASTELAO C,SENIN L L,et al.FNDC5/irisin is not only a myokine but also an adipokine[J].PLoS One,2013,8(4):e60563.
[10] MORENO-NAVARRETE J M,ORTEGA F,SERRANO M,et al.Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance[J].Journal of Clinical Endocrinology and Metabolism,2013,98(4):E769-E778.
[11] PIYA M K,HARTE A L,SIVAKUMAR K,et al.The identification of irisin in human cerebrospinal fluid:influence of adiposity,metabolic markers,and gestational diabetes[J].American Journal of Physiology Endocrinology and Metabolism,2014,306(5):E512-E518.
[12] AYDIN S,KULOGLU T,AYDIN S.Copeptin,adropin and irisin concentrations in breast milk and plasma of healthy women and those with gestational diabetes mellitus[J].Peptides,2013,47:66-70.
[13] AYDIN S,AYDIN S,KULOGLU T,et al.Alterations of irisin concentrations in saliva and serum of obese and normal-weight subjects,before and after 45 min of a Turkish bath or running[J].Peptides,2013,50:13-18.
[14] TIMMONS J A,BAAR K,DAVIDSEN P K.Is irisin a human exercise gene?[J].Nature,2012,488(7413):E9-E10.
[15] LECKER S H,ZAVIN A,CAO P R,et al.Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure[J].Circulation:Heart Failure,2012,5:812-818.
[16] LAWSON E A,ACKERMAN K E,SLATTERY M,et al.Oxytocin secretion is related to measures of energy homeosta-sis in young amenorrheic athletes[J].Journal of Clinical Endocrinology and Metabolism,2014,99(5):E881-E885.
[17] BESSE-PATIN A,MONTASTIER E,VINEL C,et al.Effect of endurance training on skeletal muscle myokine expression in obese men:identification of apelin as a novel myokine[J].International Journal of Obesity,2014,38(5):707-713.
[18] AYDIN S,KULOGLU T,AYDIN S,et al.Cardiac,skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats:cardiac muscle produces more irisin than skeletal muscle[J].Peptides,2013,52:68-73.
[19] LEE P,LINDERMAN J D,SMITH S,et al.Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans[J].Cell Metabolism,2014,19(2):302-309.
[20] KURDIOVA T,BALAZ M,MAYER A,et al.Exercise-mimicking treatment fails to increase
Fndc5 mRNA & irisin secretion in primary human myotubes[J].Peptides,2014,56:1-7.
[21] HEE P H,ZAICHENKO L,PETER P,et al.Diet quality is associated with circulating C-reactive protein but not irisin levels in humans[J].Metabolism Clinical and Experimental,2014,63(2):233-241.
[22] ITO M,NAGASAWA M,OMAE N,et al.Differential regulation of CIDEA and CIDEC expression by insulin via Akt1/2- and JNK2-dependent pathways in human adipocytes[J].Journal of Lipid Research,2011,52:1450-1460.
[23] CHOI Y K,KIM M K,BAE K H,et al.Serum irisin levels in new-onset type 2 diabetes[J].Diabetes Research and Clinic Practice,2013,100(1):96-101.
[24] LIU J J,WONG M D S,TOY W C,et al.Lower circulating irisin is associated with type 2 diabetes mellitus[J].Journal of Diabetes and Its Complications,2013,27(4):365-369.
[25] ZHANG H J,ZHANG X F,MA Z M,et al.Irisin is inversely associated with intrahepatic triglyceride contents in obese adults[J].Journal of Hepatology,2013,59(3):557-562.
[26] FAIN J N,COMPANY J M,BOOTH F W,et al.Exercise training does not increase muscle FNDC5 protein or mRNA expression in pigs[J].Metabolism Clinical and Experimental,2013,62(10):1503-1511.
[27] BAKA S,MALAMITSI-PUCHNER A,BOUTSIKOU T,et al.Cord blood irisin at the extremes of fetal growth[J].Metabolism Clinical and Experimental,2015,64(11):1515-1520.
[28] JOUNG K E,PARK K H,FILIPPAIOS A,et al.Cord blood irisin levels are positively correlated with birth weight in newborn infants[J].Metabolism Clinical and Experimental,2015,64(11):1507-1515.
[29] HUH J Y,MANTZOROS C S.Irisin physiology,oxidative stress,and thyroid dysfunction:what next?[J].Metabolism Clinical and Experimental,2015,64(7):765-767.
[30] PARK M J,KIMA D I,CHOI J H,et al.New role of irisin in hepatocytes:the protective effect of hepatic steatosis
in vitro[J].Cellular Signalling,2015,27(9):1831-1839.
[31] ZHU D,WANG H C,ZHANG J L,et al.Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nitrative stresses[J].Journal of Molecular and Cellular Cardiology,2015,87:138-147.
[32] WRANN C D,WHITE J P,SALOGIANNNIS J,et al.Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway[J].Cell Metabolism,2013,18(5):649-659.
[33] HIUKKA A,MARANGHI M,MATIKAINEN N,et al.PPARα:an emerging therapeutic target in diabetic microvascular damage[J].Nature Reviews Endocrinology,2010,6(8):454-463.
[34] ZHANG Y,LI R,MENG Y,et al.Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling[J].Diabetes,2014,63(2):514-525.
[35] LEFAUCHEUR L,HOFFMAN R K,GERRARD D E,et al.Evidence for three adult fast myosin heavy chain isoforms in type Ⅱ skeletal muscle fibers in pigs[J].Journal of Animal Science,1998,76(6):1584-1593.
[36] SCHULZ R A,YUTZEY K E.Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development[J].Developmental Biology,2004,266(1):1-16.
[37] HOGAN P G,CHEN L,NARDONE J,et al.Transcriptional regulation by calcium,calcineurin,and NFAT[J].Genes & Development,2003,17(18):2205-2232.
[38] FRAYSSE B,DESAPHY J F,PIERNO S,et al.Decrease in resting calcium and calcium entry associated with slow-to-fast transition in unloaded rat soleus muscle[J].The FASEB Journal,2003,17(13):1916-1918.
[39] EHLERS M L,CELONA B,BLACK B L.NFATc1 controls skeletal muscle fiber type and is a negative regulator of MyoD activity[J].Cell Reports,2014,8(6):1639-1648.
[40] HORSLEY V,JANSEN K M,MILLS S T,et al.IL-4 acts as a myoblast recruitment factor during mammalian muscle growth[J].Cell,2003,113(4):483-494.
[41] NAYA F J,OLSON E.MEF2:a transcriptional target for signaling pathways controlling skeletal muscle growth and differentiation[J].Current Opinion in Cell Biology,1999,11(6):683-688.
[42] WU H,ROTHERMEL B,KANATOUS S,et al.Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway[J].The EMBO Journal,2001,20(22):6414-6423.
[43] NISSIM H.Biochimica et biophysica acta (BBA)-molecular[J].Cell Research,2011(1813):1965-1970.
[44] KAMEI Y,MIURA S,SUZUKI M,et al.Skeletal muscle FoxO1(FKHR)-transgenic mice have less skeletal muscle mass,down-regulated type I (slow twitch/red muscle) fiber genes,and impaired glycemic control[J].Journal of Biological Chemistry,2004,279(39):41114-41123.
[45] 杨燕军,庞卫军,白亮,等.八眉猪、长白猪及长×八杂交猪肌肉组织中
FoxO1基因的表达[J].遗传,2008,30(2):185-189.
[46] 庞卫军.猪
FoxO1基因cDNA的克隆及对前体脂肪细胞和成肌细胞分化的调控作用[D].博士学位论文.杨凌:西北农林科技大学,2007.
[47] FERNANDEZ-MARCOS P J,AUWERX J.Regulation of PGC-1α,a nodal regulator of mitochondrial biogenesis[J].American Society for Nutrition,2011,93(4):884S-890S.
[48] HANDSCHIN C,CHIN S,LI P,et al.BM.Skeletal muscle fiber-type switching,exercise in tolerance,and myopathy in PGC-1α muscle-specific knock-out animals[J].Journal of Biological Chemistry,2007,282(41):30014-30021.
[49] MORTENSEN O H,FRANDSEN L,SCHJERLING P,et al.PGC-1α and PGC-1β have both similar and distinct effects on myofiber switching toward an oxidative phenotype[J].American Journal of Physiology Endocrinology and Metabolism,2006,291(4):E807-E816.
[50] LEONE T C,LEHMAN J J,FINCK B N,et al.PGC-1α deficiency causes multi-system energy metabolic derangements:muscle dysfunction,abnormal weight control and hepatic steatosis[J].PLoS Biology,2005,3(4):672-687.
[51] SVENSSON K,HANDSCHIN C.Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases[J].Drug Discovery Today,2014,19(7):1024-1029.
[52] HUH J Y,DINCER F,MESFUM E,et al.Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans[J].International Journal of Obese,2014,38(12):1538-1544.
[53] STARON R S,KARAPONDO D L,KRAEMER W J,et al.Skeletal muscle adaptations during early phase of heavy-resistance training in men and women[J].Journal of Applied Physiology,1994,76(3):1247-1255.
[54] CAIOZZO V J,HADDAD F,BAKER M J,et al.Microgravity-induced transformations of myosin isoforms and contractile properties of skeletal muscle[J].Journal of Applied Physiology,1996,81(1):123-132.
[55] BEE G.Effect of early-gestation feeding,birth weight,and gender of progeny on muscle fiber characteristics of pigs at slaughter[J].Journal of Animal Science,2004,82(3):826-836.
[56] 徐子伟,门小明,齐珂珂.猪肌肉纤维类型及其代谢特征与肉质形成的关系及机理探讨[C]//动物营养研究进展(2012年版).北京:中国农业科学技术出版社,2012:85-96.
[57] BRONDANI L A,BOELTER G,ASSMANN T S,et al.Irisin-encoding gene (
FNDC5) variant is associated with changes in blood pressure and lipid profile in type 2 diabetic women but not in men[J].Metabolism Clinical and Experimental,2015,64(9):952-957.
[58] TANISAWA K,TANIGUCHI H,SUN X M,et al.Common single nucleotide polymorphisms in the
FNDC5 gene are associated with glucose metabolism but do not affect serum irisin levels in Japanese men with low fitness levels[J].Metabolism Clinical and Experimental,2014,63(4):574-583.
[59] ZADEGAN F G,GHAEDI K,KALANTAR S M,et al.Cardiac differentiation of mouse embryonic stem cells is influenced by a PPARγ/PGC-1α-FNDC5 pathway during the stage of cardiac precursor cell formation[J].European Journal of Cell Biology,2015,94(6):257-266.
