REVIEW

The Orexigenic Role and Mechanism of Neuropeptide Y

  • WANG Guowen ,
  • SHAO Baoping ,
  • DING Yanping
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  • 1. School of Life Science, Northwest Normal University, Lanzhou 730070, China;
    2. Institute of Zoology and Developmental Biology, College of Life Sciences, Lanzhou University, Lanzhou 730000, China

Received date: 2015-09-01

  Online published: 2016-02-19

Abstract

Neuropeptide Y (NPY) is a neurotransmitter widely spread in central and peripheral nervous system for sustaining homeostasis. The prominent role for NPY is its regulation of food intake. NPY neurons are mainly localized in arcuate nucleus (ARC) of hypothalamus. The projection of these neurons mainly reach paraventricular nucleus (PVN), ventromedial nucleus (VMN), lateral hypothalamic area (LHA) and dorsomedial nucleus (DMN) of hypothalamus forming synaptic connection and further regulate food intake. NPY receptors are Gi/Go-protein coupled receptors including Y1 to Y8 8 kinds of subtypes. Y1 receptor plays a major role in the regulation of energy metabolism. This article reviews the structure of NPY and its role of regulating food intake in ARC, PVN, VMN, LHA and DMN providing basic material for relative research.

Cite this article

WANG Guowen , SHAO Baoping , DING Yanping . The Orexigenic Role and Mechanism of Neuropeptide Y[J]. Chinese Journal of Animal Nutrition, 2016 , 28(2) : 385 -391 . DOI: 10.3969/j.issn.1006-267x.2016.02.011

References

[1] SAH R,GERACIOTI T D.Neuropeptide Y and posttraumatic stress disorder[J].Molecular Psychiatry,2013,18(6):646-655.  
[2] STANLEY B G,LEIBOWITZ S F.Neuropeptide Y injected in the paraventricular hypothalamus:a powerful stimulant of feeding behavior[J].Proceedings of the National Academy of Sciences of the United States of America,1985,82(11):3940-3943.  
[3] MINER J L,DELLA-FERA M A,PATERSON J A,et al.Lateral cerebroventricular injection of neuropeptide Y stimulates feeding in sheep[J].American Journal of Physiology:Regulatory,Integrative and Comparative Physiology,1989,257(2):R383-R387.
[4] SHERMAN E L,NKRUMAH J D,MURDOCH B M,et al.Polymorphisms and haplotypes in the bovine neuropeptide Y,growth hormone receptor,ghrelin,insulin-like growth factor 2,and uncoupling proteins 2 and 3 genes and their associations with measures of growth,performance,feed efficiency,and carcass merit in beef cattle[J].Journal of Animal Science,2008,86(1):1-16.
[5] GEHLERT D R.Introduction to the reviews on neuropeptide Y[J].Neuropeptides,2004,38(4):135-140.  
[6] MERCER R E,CHEE M J S,COLMERS W F.The role of NPY in hypothalamic mediated food intake[J].Frontiers in Neuroendocrinology,2011,32(4):398-415.  
[7] KOHNO D,YADA T.Arcuate NPY neurons sense and integrate peripheral metabolic signals to control feeding[J].Neuropeptides,2012,46(6):315-319.  
[8] HAHN T M,BREININGER J F,BASKIN D G,et al.Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons[J].Nature Neuroscience,1998,1(4):271-272.  
[9] APONTE Y,ATASOY D,STERNSON S M.AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training[J].Nature Neuroscience,2011,14(3):351-355.  
[10] SOUSA-FERREIRA L,GARRIDO M,NASCIMENTO-FERREIRA I,et al.Moderate long-term modulation of neuropeptide Y in hypothalamic arcuate nucleus induces energy balance alterations in adult rats[J].PLoS One,2011,6(7):e22333.
[11] LUQUET S,PEREZ F A,HNASKO T S,et al.NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates[J].Science,2005,310(5748):683-685.  
[12] BOURET S G,DRAPER S J,SIMERLY R B.Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice[J].The Journal of Neuroscience,2004,24(11):2797-2805.  
[13] GHAMARI-LANGROUDI M,COLMERS W F,CONE R D.PYY3-36 inhibits the action potential firing activity of POMC neurons of arcuate nucleus through postsynaptic Y2 receptors[J].Cell Metabolism,2005,2(3):191-199.  
[14] SAHU A,KALRA P S,KALRA S P.Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus[J].Peptides,1988,9(1):83-86.  
[15] KOTZ C M,BRIGGS J E,GRACE M K,et al.Divergence of the feeding and thermogenic pathways influenced by NPY in the hypothalamic PVN of the rat[J].American Journal of Physiology:Regulatory,Integrative and Comparative Physiology,1998,275(2):R471-R477.
[16] LONG M,ZHOU J Y,LI D D,et al.Long-term over-expression of neuropeptide Y in hypothalamic paraventricular nucleus contributes to adipose tissue insulin resistance partly via the Y5 Receptor[J].PLoS One,2015,10(5):e0126714.
[17] YOUNES-RAPOZO V,DE MOURA E G,DA SILVA LIMA N,et al.Early weaning is associated with higher neuropeptide Y (NPY) and lower cocaine-and amphetamine-regulated transcript (CART) expressions in the paraventricular nucleus (PVN) in adulthood[J].British Journal of Nutrition,2012,108(12):2286-2295.  
[18] ATASOY D,BETLEY J N,SU H H,et al.Deconstruction of a neural circuit for hunger[J].Nature,2012,488(7410):172-177.  
[19] KRASHES M J,SHAH B P,MADARA J C,et al.An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger[J].Nature,2014,507(7491):238-242.  
[20] PRONCHUK N,COLMERS W F.NPY presynaptic actions are reduced in the hypothalamic mpPVN of obese (fa/fa),but not lean,Zucker rats in vitro[J].British Journal of Pharmacology,2004,141(6):1032-1036.  
[21] CONE R D.Anatomy and regulation of the central melanocortin system[J].Nature Neuroscience,2005,8(5):571-578.  
[22] GHAMARI-LANGROUDI M,SRISAI D,CONE R D.Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin[J].Proceedings of the National Academy of Sciences of the United States of America,2011,108(1):355-360.  
[23] CHEE M J S,MYERS M G,Jr,PRICE C J,et al.Neuropeptide Y suppresses anorexigenic output from the ventromedial nucleus of the hypothalamus[J].The Journal of Neuroscience,2010,30(9):3380-3390.  
[24] STERNSON S M,SHEPHERD G M G,FRIEDMAN J M.Topographic mapping of VMH→ arcuate nucleus microcircuits and their reorganization by fasting[J].Nature Neuroscience,2005,8(10):1356-1363.  
[25] BERTHOUD H R,MVNZBERG H.The lateral hypothalamus as integrator of metabolic and environmental needs:from electrical self-stimulation to opto-genetics[J].Physiology & Behavior,2011,104(1):29-39.  
[26] PARKER J A,BLOOM S R.Hypothalamic neuropeptides and the regulation of appetite[J].Neuropharmacology,2012,63(1):18-30.  
[27] BROBERGER C,DE LECEA L,SUTCLIFFE J G,et al.Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus:relationship to the neuropeptide Y and Agouti gene-related protein systems[J].Journal of Comparative Neurology,1998,402(4):460-474.  
[28] HORVATH T L,DIANO S,VAN DEN POL A N.Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus:a novel circuit implicated in metabolic and endocrine regulations[J].The Journal of Neuroscience,1999,19(3):1072-1087.
[29] YANG L,SCOTT K A,HYUN J,et al.Role of dorsomedial hypothalamic neuropeptide Y in modulating food intake and energy balance[J].The Journal of Neuroscience,2009,29(1):179-190.  
[30] BI S,KIM Y J,ZHENG F P.Dorsomedial hypothalamic NPY and energy balance control[J].Neuropeptides,2012,46(6):309-314.  
[31] BI S.Role of dorsomedial hypothalamic neuropeptide Y in energy homeostasis[J].Peptides,2007,28(2):352-356.  
[32] CHAO P T,YANG L,AJA S,et al.Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity[J].Cell Metabolism,2011,13(5):573-583.  
[33] BI S.Dorsomedial hypothalamic NPY modulation of adiposity and thermogenesis[J].Physiology & Behavior,2013,121:56-60.
[34] LARHAMMAR D,SALANECK E.Molecular evolution of NPY receptor subtypes[J].Neuropeptides,2004,38(4):141-151.  
[35] WALTHER C,MÖRL K,BECK-SICKINGER A G.Neuropeptide Y receptors:ligand binding and trafficking suggest novel approaches in drug development[J].Journal of Peptide Science,2011,17(4):233-246.  
[36] ZHANG L,BIJKER M S,HERZOG H.The neuropeptide Y system:pathophysiological and therapeutic implications in obesity and cancer[J].Pharmacology & Therapeutics,2011,131(1):91-113.  
[37] MAHAUT S,DUMONT Y,FOURNIER A,et al.Neuropeptide Y receptor subtypes in the dorsal vagal complex under acute feeding adaptation in the adult rat[J].Neuropeptides,2010,44(2):77-86.  
[38] EVA C,SERRA M,MELE P,et al.Physiology and gene regulation of the brain NPY Y1 receptor[J].Frontiers in Neuroendocrinology,2006,27(3):308-339.  
[39] BECK B,RICHY S,DIMITROV T,et al.Opposite regulation of hypothalamic orexin and neuropeptide Y receptors and peptide expressions in obese Zucker rats[J].Biochemical and Biophysical Research Communications,2001,286(3):518-523.  
[40] WANG C,YANG N,WU S,et al.Difference of NPY and its receptor gene expressions between obesity and obesity-resistant rats in response to high-fat diet[J].Hormone and Metabolic Research,2007,39(4):262-267.  
[41] ZAMMARETTI F,PANZICA G,EVA C.Sex-dependent regulation of hypothalamic neuropeptide Y-Y1 receptor gene expression in moderate/high fat,high-energy diet-fed mice[J].The Journal of Physiology,2007,583(2):445-454.  
[42] ZAMMARETTI F,PANZICA G,EVA C.Fasting,leptin treatment,and glucose administration differentially regulate Y1 receptor gene expression in the hypothalamus of transgenic mice[J].Endocrinology,2001,142(9):3774-3782.  
[43] CHENG X P,BROBERGER C,TONG Y G,et al.Regulation of expression of neuropeptide Y Y1 and Y2 receptors in the arcuate nucleus of fasted rats[J].Brain Research,1998,792(1):89-96.  
[44] JANSSEN P,VERSCHUEREN S,ROTONDO A,et al.Role of Y2 receptors in the regulation of gastric tone in rats[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2012,302(7):G732-G739.
[45] CHATREE S,CHURINTARAPHAN M,NWAY N C,et al.Expression of Y2R mRNA expression in subcutaneous and visceral adipose tissues compared between normal weight and obese female subjects[J].Siriraj Medical Journal,2013,65(6):163-167.
[46] AMSTALDEN M,CARDOSO R C,ALVES B R C,et al.reproduction symposium:hypothalamic neuropeptides and the nutritional programming of puberty in heifers[J].Journal of Animal Science,2014,92(8):3211-3222.  
[47] KEISLER D H,LUCY M C.Perception and interpretation of the effects of undernutrition on reproduction[J].Journal of Animal Science,1996,74(Suppl 3):1-17.
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