This study was aimed to investigate the effects of mulberry leaf powder on growth performance, meat quality and serum biochemical indexes in finishing pigs. One hundred and sixty ‘Duroc×Yorkshire×Landrace’ health finishing pigs with initial weight of (87.10±5.33) kg were randomly divided into four groups with four replicates in each group and ten pigs in each replicate. Pigs in the four groups were fed with a basal diet (control group, group Ⅰ), the basal diet containing 5% mulberry leaf powder (group Ⅱ), the basal diet containing 10% mulberry leaf powder (group Ⅲ),and the basal diet containing 15% mulberry leaf powder (group Ⅳ), respectively. The experiment lasted for 50 days. The results showed as follows:compared with the control group, 1) the average daily gain of finishing pigs fed diet containing 5% and 10% mulberry leaf powder was not significantly different (P>0.05), the average daily gain was significantly decreased and the ratio of feed to gain was significantly increased in pigs fed diet containing 15% mulberry leaf powder (P<0.05). 2) Shear force and pH of muscle at 45 min and 24 h post-slaughter were not significantly different in finishing pigs fed diet containing 5% and 10% mulberry leaf powder (P>0.05), but marbling score was increased with no significantly different (P>0.05). Backfat thickness and cholesterol content in muscle were significantly decreased in pigs fed diet containing 15% mulberry leaf powder (P<0.05). 3) As diet mulberry leaf powder level was 5%, 10% and 15%, the SOD activity was significantly increased (P<0.05) and malonaldehyde content was significantly decreased (P>0.05), and the antioxidant performance of muscle was improved. 4) Urea nitrogen content in serum was significantly increased in pigs fed diets containing 5%, 10% and 15% mulberry leaf powder (P<0.05), lipase activity was decreased with no significantly different (P>0.05), and triglyceride content was significantly decreased in pigs fed diet containing 15% mulberry leaf powder (P<0.05). In conclusion, diet containing 10% mulberry leaf powder has less effect on the growth rate of finishing pigs, while can improve meat quality.