Review

Mechanisms of Impact of Obesity on Respiratory Infection

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  • Key Laboratory of Animal Disease and Human Health of Sichuan Province, Key Laboratory of Environmental Hazard and Animal Disease of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China

Received date: 2015-09-10

  Online published: 2016-03-14

Abstract

Obesity is a chronic metabolic disease caused by many factors, and it is also a kind of systemic low grade inflammation, which affects both the energy metabolism and immune state in the body. A large numbers of studies have reported that obesity has a certain effect on the function of respiratory system, which not only improves the severity of respiratory diseases, increases the risk of respiratory tract infections, also destroys the capacity to clear the pathogens. Even though, there are some voices said that obesity is associated with lower odds and hospital mortality, but the specific mechanism is still unknown. It is clear that the increased inflammatory cells infiltration and the elevated inflammatory mediators and adipocytokines caused by the substantial accumulation of adipose tissue in obese individuals may be the main factors contributing to the alters of lung susceptibility to pathogenic microorganisms. This review summarizes the mechanisms of obesity may affect respiratory resistance to infections, to lay a certain foundation for further exploring the relationship between obesity and lung infection.

Cite this article

WAN Taomei, GAN Linli, ZUO Zhicai, REN Yi . Mechanisms of Impact of Obesity on Respiratory Infection[J]. Chinese Journal of Animal Nutrition, 2016 , 28(3) : 695 -703 . DOI: 10.3969/j.issn.1006-267x.2016.03.009

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