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Effects of Clostridium butyricum on Growth Performance, Antioxidant Capacity, Immune Function and Serum Biochemical Parameters of Broilers

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  • 1. College of Animal Science and Technology, Zhejiang A & F University, Lin'an 313000, China;
    2. College of Animal Sciences, Zhejiang University, Hangzhou 310058, China;
    3. Zhejiang Huijia Biological Technology Co., Ltd., Anji 313307, China

Received date: 2015-09-20

  Online published: 2016-03-14

Abstract

This experiment was conducted to investigate the effects of Clostridium butyricum on growth performance, antioxidant capacity, immune function and serum biochemical parameters of broilers. A total of 540 one-day-old Ross 308 broilers were randomly assigned to 3 groups with 6 replicates per group and 30 birds per replicate for a 42-day trial. Dietary treatments were: an antibiotic-free basal diet (control group, CON), basal diet supplemented with 10 mg/kg colistin sulfate and 50 mg/kg bacitracin zinc (antibiotic group, ANT), and basal diet supplemented with 3×108 CFU/kg Clostridium butyricum (Clostridium butyricum group, CB). The results showed as follows: 1) the body weight (BW), average daily gain (ADG) and average daily feed intake (ADFI) of broilers in CB and ANT were significantly increased (P<0.05) compared with those in CON. 2) The activities of serum glutathione peroxidase (GSH-Px) and total superoxide dismutase (T-SOD) in broilers at 42 days of age were significantly enhanced (P<0.05) compared with those in CON, and GSH-Px activity was 60.00% higher (P<0.05) than that in ANT. At 7 and 21 days of age, serum T-SOD activity of broilers in ANT was significantly increased (P<0.05) compared with that in CON. 3) Compared with CON, serum immunoglobulin A (IgA) content in broilers at 21 days of age in CB and ANT was increased by 28.70% (P<0.05) and 26.46% (P<0.05), and serum immunoglobulin G (IgG) content in broilers at 7, 21 and 42 days of age was increased by 36.60% (P<0.05), 37.77% (P<0.05) and 27.03% (P<0.05), respectively. Serum IgG content of broilers at 7 and 42 days of age in ANT was significantly higher (P<0.05) than that in CON. Serum immunoglobulin M (IgM) content of broilers at 21 and 42 days of age in CB was significantly increased compared with CON, while 7.92% (P>0.05) and 47.62% (P<0.05) higher than that in ANT. 4) Serum total protein (TP) content of broilers in CB was significantly higher (P<0.05) than that in CON, especially increased by 31.33% (P<0.05) and 52.27% (P<0.05) compared with that of broilers at 21 and 42 days of age in ANT. Meanwhile, serum ammonia content of broilers in CB was significantly decreased (P<0.05) compared with that of broilers at 21 and 42 days of age in CON. These results indicated that supplementation with Clostridium butyricum in diet can enhance serum antioxidant capacity and immune function, promote protein metabolism, and then improve the growth performance of broilers;moreover, it can aslo reduce ammonia emissions from broilers.

Cite this article

JIA Conghui, YANG Caimei, ZENG Xinfu, LIU Jinsong, ZHANG Juan, CHEN Anguo . Effects of Clostridium butyricum on Growth Performance, Antioxidant Capacity, Immune Function and Serum Biochemical Parameters of Broilers[J]. Chinese Journal of Animal Nutrition, 2016 , 28(3) : 908 -915 . DOI: 10.3969/j.issn.1006-267x.2016.03.033

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