REVIEW

Aquaporin:Effects on Intestinal Health Regulation

  • ZHU Cui ,
  • BAI Yinshan ,
  • CHEN Zhuang ,
  • JIANG Zongyong
Expand
  • 1. Agro-Biological Gene Research Center, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China;
    2. School of Basic Sciences, Guangzhou Medical University, Guangzhou 511436, China;
    3. Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China

Received date: 2015-11-03

  Online published: 2016-04-11

Abstract

Aquaporin(AQP), widely distributed in the gastrointestinal tissues of human and mammals, is a kind of plasma membrane channel protein that selectively transports water molecules efficiently, and plays important roles in fluid transport and digestive physiology. This review focused on the structure and classifications of AQP, and its expression and distributions in the gastrointestinal tracts of human, rodents and piglets, and further discussed the relations and roles of AQP in the development of diarrhea, regulation on migration and repair of intestinal epithelial cells, intestinal barrier functions, and intestinal inflammation-associated disease.

Cite this article

ZHU Cui , BAI Yinshan , CHEN Zhuang , JIANG Zongyong . Aquaporin:Effects on Intestinal Health Regulation[J]. Chinese Journal of Animal Nutrition, 2016 , 28(4) : 961 -967 . DOI: 10.3969/j.issn.1006-267x.2016.04.001

References

[1] VERKMAN A S,MITRA A K.Structure and function of aquaporin water channels[J].American Journal of Physiology-Renal Physiology,2000,278(1):F13-F28.
[2] AGRE P,PRESTON G M,SMITH B L,et al.Aquaporin CHIP:the archetypal molecular water channel[J].American Journal of Physiology,1993,265(4):F463-F476.
[3] ZEUTHEN T.Water-transporting proteins[J].Journal of Membrane Biology,2010,234(2):57-73.  
[4] ISHIBASHI K,HARA S,KONDO S.Aquaporin water channels in mammals[J].Clinical and Experimental Nephrology,2009,13(2):107-117.  
[5] HOLM L M,KLAERKE D A,ZEUTHEN T.Aquaporin 6 is permeable to glycerol and urea[J].Pflugers Archiv-European Journal of Physiology,2004,448(2):181-186.  
[6] LITMAN T,SØGAARD R,ZEUTHEN T.Ammonia and urea permeability of mammalian aquaporins[M]//BEITZ,ERIC.Aquaporins.Heidelberg:Springer Berlin,2009:327-358.
[7] ISHIBASHI K,YAMAUCHI K,KAGEYAMA Y,et al.Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping[J].Biochimica et Biophysica Acta:Gene Structure and Expression,1998,1399(1):62-66.  
[8] HERRERA M,GARVIN J L.Aquaporins as gas channels[J].Pflugers Archiv-European Journal of Physiology,2011,462(4):623-630.  
[9] LIU H,ZHENG Z,WINTOUR E M.Aquaporins and fetal fluid balance[J].Placenta,2008,29(10):840-847.  
[10] HATAKEYAMA S,YOSHIDA Y,TANI T,et al.Cloning of a new aquaporin(AQP10) abundantly expressed in duodenum and jejunum[J].Biochemical and Biophysical Research Communications,2001,287(4):814-819.  
[11] ITOH T,RAI T,KUWAHARA M,et al.Identification of a novel aquaporin,AQP12,expressed in pancreatic acinar cells[J].Biochemical Biophysical Research Communications,2005,330(3):832-838.  
[12] OKADA S,MISAKA T,MATSUMOTO I,et al.Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine[J].FEBS Letters,2003,540(1/2/3):157-162.
[13] MOBASHERI A,MARPLES D.Expression of the AQP-1 water channel in normal human tissues:a semiquantitative study using tissue microarray technology[J].American Journal of Physiology:Cell Physiology,2004,286(3):C529-C537.
[14] LI H P,KAMⅡE J,MORISHITA Y,et al.Expression and localization of two isoforms of AQP10 in human small intestine[J].Biology of the Cell,2005,97(11):823-829.  
[15] WATANABE T,FUJⅡ T,OYA T,et al.Involvement of aquaporin-5 in differentiation of human gastric cancer cells[J].The Journal of Physiological Sciences,2009,59(2):113-122.  
[16] LAFORENZA U,MICELI E,GASTALDI G,et al.Solute transporters and aquaporins are impaired in celiac disease[J].Biology of the Cell,2010,102(8):457-467.  
[17] RAMÍREZ-LORCA R,VIZUETE M L,VENERO J L,et al.Localization of aquaporin-3 mRNA and protein along the gastrointestinal tract of Wistar rats[J].Pflugers Archiv-European Journal of Physiology,1999,438(1):94-100.  
[18] WANG K S,MA T,FILIZ F,et al.Colon water transport in transgenic mice lacking aquaporin-4 water channels[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2000,279(2):G463-G470.
[19] GALLARDO P,CID L P,VIO C P,et al.Aquaporin-2,a regulated water channel,is expressed in apical membranes of rat distal colon epithelium[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2001,281(3):G856-G863.
[20] PARVIN NAHID M,TSUMURA K,AKAMATSU T,et al.Expression and localization of AQP5 in the stomach and duodenum of the rat[J].Biochim Biophys Acta:Molecular Cell Research,2002,1542(1/2/3):116-124.
[21] MATSUZAKI T,TAJIKA Y,SUZUKI T,et al.Immunolocalization of the water channel,aquaporin-5(AQP5),in the rat digestive system[J].Archives of Histology and Cytology,2003,66:307-315.
[22] HUANG Y,TOLA V B,FANG P K,et al.Partitioning of aquaporin-4 water channel mRNA and protein in gastric glands[J].Digestibe Diseases and Sciences,2003,48(10):2027-2036.  
[23] HARDIN J A,WALLACE L E,WONG J F K,et al.Aquaporin expression is downregulated in a murine model of colitis and in patients with ulcerative colitis,Crohn's disease and infectious colitis[J].Cell and Tissue Research,2004,318(2):313-323.  
[24] LAFORENZA U,COVA E,GASTALDI G,et al.Aquaporin-8 is involved in water transport in isolated superficial colonocytes from rat proximal colon[J].The Journal of Nutrition,2005,135(10):2329-2336.
[25] IKARASHI N.The elucidation of the function and the expression control mechanism of aquaporin-3 in the colon[J].Yakugaku Zasshi-Journal of the Pharmaceutical Society of Japan,2013,133(9):955-961.  
[26] SAKAI H,SAGARA A,MATSUMOTO K,et al.5-Fluorouracil induces diarrhea with changes in the expression of inflammatory cytokines and aquaporins in mouse intestines[J].PLoS One,2013,8(1):e54788.
[27] JIN S Y,LIU Y L,XU L N,et al.Cloning and characterization of porcine aquaporin 1 water channel expressed extensively in gastrointestinal system[J].World Journal of Gastroenterology,2006,12(7):1092-1097.  
[28] HOU Y Q,WANG L,YI D,et al.N-acetylcysteine reduces inflammation in the small intestine by regulating redox,EGF and TLR4 signaling[J].Amino Acids,2013,45(3):513-522.  
[29] 台玉磊.荧光定量PCR检测仔猪断奶前后水通道蛋白基因mRNA表达差异[D].硕士学位论文.郑州.河南农业大学,2009:25-30.
[30] 李明堂,付玉,王清爽,等.猪水通道蛋白AQP1多克隆抗体制备及其在猪体内的免疫定位[J].吉林农业大学学报,2011,33(2):218-221,226.
[31] LAFORENZA U.Water channel proteins in the gastrointestinal tract[J].Molecular Aspects of Medicine,2012,33(5/6):642-650.
[32] LOO D D F,ZEUTHEN T,CHANDY G,et al.Cotransport of water by the Na+/glucose cotransporter[J].Proceedings of the National Academy of Sciences of the United States of America,1996,93(23):13367-13370.  
[33] WRIGHT E M,LOO D D F.Coupling between Na+,sugar,and water transport across the intestine[J].Annals of the New York Academy of Sciences,2000,915:54-66.
[34] MOLLAJEW R,ZOCHER F,HORNER A,et al.Routes of epithelial water flow:aquaporins versus cotransporters[J].Biophysical Journal,2010,99(11):3647-3656.  
[35] WORMAN H J,FIELD M.Osmotic water permeability of small intestinal brush-border membranes[J].The Journal of Membrane Biology,1985,87(3):233-239.  
[36] YAMAMOTO T,KURAMOTO H,KADOWAKI M.Downregulation in aquaporin 4 and aquaporin 8 expression of the colon associated with the induction of allergic diarrhea in a mouse model of food allergy[J].Life Sciences,2007,81(2):115-120.  
[37] ARGENZIO R A.Physiology of diarrhea-large intestine[J].Journal of the American Veterinary Medical Association,1978,173(5 Pt 2):667-672.
[38] BORENSHTEIN D,FRY R C,GROFF E B,et al.Diarrhea as a cause of mortality in a mouse model of infectious colitis[J].Genome Biology,2008,9(8):R122.
[39] FLACH C F,QADRI F,BHUIYAN T R,et al.Differential expression of intestinal membrane transporters in cholera patients[J].FEBS Letters,2007,581(17):3183-3188.  
[40] LOOS M,GEENS M,SCHAUVLIEGE S,et al.Role of heat-stable enterotoxins in the induction of early immune responses in piglets after infection with enterotoxigenic Escherichia coli[J].PLoS One,2012,7(7):e41041.
[41] PAPADOPOULOS M C P,SAADOUN S,VERKMAN A S.Aquaporins and cell migration[J].Pflugers Archiv-European Journal of Physiology,2008,456(4):693-700.  
[42] KARLSSON T,CHRISTOFFER LAGERHOLM B,VIKSTRÖM E,et al.Water fluxes through aquaporin-9 primeepithelial cells for rapid wound healing[J].Biochemical and Biophysical Research Communications,2013,430(3):993-998.  
[43] THIAGARAJAH J R,ZHAO D,VERKMAN A S.Impaired enterocyte proliferation in aquaporin-3 deficiency in mouse models of colitis[J].Gut,2007,56(11):1529-1535.  
[44] 桂治府.水通道蛋白4对结肠癌细胞迁移能力的影响[D].硕士学位论文.南京:南京医科大学,2012:12-38.
[45] MATSUZAKI T,SUZUKI T,KOYAMA H,et al.Water channel protein AQP3 is present in epithelia exposed to the environment of possible water loss[J].Journal of Histochemistry & Cytochemistry,1999,47(10):1275-1286.  
[46] ZHI X F,TAO J Q,LI Z L,et al.MiR-874 promotes intestinal barrier dysfunction through targeting AQP3 following intestinal ischemic injury[J].FEBS Letters,2014,588(5):757-763.  
[47] ZHANG W J,XU Y,CHEN Z,et al.Knockdown of aquaporin 3 is involved in intestinal barrier integrity impairment[J].FEBS Letters,2011,585(19):3113-3119.  
[48] FISCHER H,STENLING R,RUBIO C,et al.Differential expression of aquaporin 8 in human colonic epithelial cells and colorectal tumors[J].BMC Physiology,2001,1:1-5.
[49] ZHAO G X,LI J,WANG J Y,et al.Aquaporin 3 and 8 are down-regulated in TNBS-induced rat colitis[J].Biochemical Biophysical Research Communications,2014,443(1):161-166.  
[50] ZAHN A,MOEHLE C,LANGMANN T,et al.Aquaporin-8 expression is reduced in ileum and induced in colon of patients with ulcerative colitis[J].World Journal of Gastroenterology,2007,13(11):1687-1695.  
Outlines

/