REVIEW

Distribution and Biological Functions of a Novel Anorexigenic Neuropeptide Nesfatin-1

  • DENG Qiuhong ,
  • JIA Gang ,
  • ZHAO Hua ,
  • CHEN Xiaoling ,
  • LIU Guangmang ,
  • CAI Jingyi ,
  • TANG Jiayong
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  • Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China

Received date: 2015-10-22

  Online published: 2016-04-11

Abstract

Nesfatin-1 is a newly discovered anorexia neuropeptides. nesfatin-1 is found to be prominently expressed in hypothalamic and brainstem nuclei and especially in peripheral gastrointestinal and pancreatic endocrine cells and gonads. Its expression is influenced by nutrition, physiology, pathology and other feeding related hormones. The centrally and peripherally intracellular co-localization of nesfatin-1 immunore activity with several hormones points towards differential regulation and consequently functions in the control of food intake and glucose homeostasis, and the physiological process of stress response and puberty onset by hypothalamic-pituitary-adrenal axis(HPA) and hypothalamic-pituitary-gonadal axis activation, respectively. This review focuses on the central and peripheral distribution, the factors affecting the expression, and the biological functions ofnesfatin-1.

Cite this article

DENG Qiuhong , JIA Gang , ZHAO Hua , CHEN Xiaoling , LIU Guangmang , CAI Jingyi , TANG Jiayong . Distribution and Biological Functions of a Novel Anorexigenic Neuropeptide Nesfatin-1[J]. Chinese Journal of Animal Nutrition, 2016 , 28(4) : 1004 -1010 . DOI: 10.3969/j.issn.1006-267x.2016.04.006

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