REVIEW

Regulation of Silent Information Regulator 1 on Lipid Metabolism

  • WU Tiemei ,
  • YAN Sumei ,
  • Gerelmaa
Expand
  • College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China

Received date: 2015-11-17

  Online published: 2016-05-24

Abstract

Silent information regulator 1(SIRT1) can inhibit the transcription activity of lipogenic-related genes peroxisome proliferator-activated receptors gamma (PPARγ) and sterol regulatory element binding factor 1 c (SREBP1c) through the deacetylation, resulting in inhibiting anabolism of lipid and promoting catabolism. In addition, SIRT1 reduces lipid anabolism, accelerates lipolysis and reduces fat deposition, which may be associated with regulating the SIRT1-adenosine 5'-monophosphate-activated protein kinase (AMPK) and SIRT1-mammalian target of rapamycin (mTOR) signaling pathways. This review summarizes the regulation of SIRT1 on animal lipid metabolism via related transcription factors and signaling pathways, which provides the basis for the further investigation of animal lipid metabolism and improving meat quality.

Cite this article

WU Tiemei , YAN Sumei , Gerelmaa . Regulation of Silent Information Regulator 1 on Lipid Metabolism[J]. Chinese Journal of Animal Nutrition, 2016 , 28(5) : 1285 -1293 . DOI: 10.3969/j.issn.1006-267x.2016.05.001

References

[1] 王晓凯,张志成,孙天胜.SIRT1的生理作用及调控机制的研究进展[J].中华临床医师杂志,2011,5(24):7315-7318.
[2] PICARD F,KURTEV M,CHUNG N,et al.Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ[J].Nature,2004,429(6993):771-776.  
[3] MANNEN H.Identification and utilization of genes associated with beef qualities[J].Animal Science Journal,2011,82(1):1-7.  
[4] TANIGUCHI M,GUAN L L,ZHANG B,et al.Gene expression patterns of bovine perimuscular pre-adipocytes during adipogenesis[J].Biochemical and Biophysical Research Communications,2008,366(2):346-351.  
[5] FERNYHOUGH M E,HELTERLINE D I,VIERCK J L,et al.Dedifferentiation of mature adipocytes to form adipofibroblasts:more than just a possibility[J].Adipocytes,2005,1(1):17-24.
[6] WANG Y H,BYRNE K A,REVERTER A,et al.Transcriptional profiling of skeletal muscle tissue from two breeds of cattle[J].Mammalian Genome,2005,16(3):201-210.  
[7] LEHNERT S A,REVERTER A,BYRNE K A,et al.Gene expression studies of developing bovine longissimus muscle from two different beef cattle breeds[J].BMC Developmental Biology,2007,7(1):95.
[8] ZHANG Q K,LEE H G,HAN J A,et al.Differentially expressed proteins during fat accumulation in bovine skeletal muscle[J].Meat Science,2010,86(3):814-820.  
[9] LEE S H,GONDRO C,VAN DER WERF J,et al.Use of a bovine genome array to identify new biological pathways for beef marbling in Hanwoo (Korean Cattle)[J].BMC Genomics,2010,11(1):623.
[10] ANGHEL S I,WAHLI W.Fat poetry:a kingdom for PPARγ[J].Cell Research,2007,17(6):486-511.  
[11] CHRISTODOULIDES C,VIDAL-PUIG A.PPARs and adipocyte function[J].Molecular and Cellular Endocrinology,2010,318(1/2):61-68.
[12] WHITE U A,STEPHENS J M.Transcriptional factors that promote formation of white adipose tissue[J].Molecular and Cellular Endocrinology,2010,318(1/2):10-14.
[13] SIERSBÆK R,NIELSEN R,MANDRUP S.PPARγ in adipocyte differentiation and metabolism-novel insights from genome-wide studies[J].FEBS Letters,2010,584(15):3242-3249.  
[14] TONTONOZ P,SPIEGELMAN B M.Fat and beyond:the diverse biology of PPARγ[J].Annual Review of Biochemistry,2008,77(1):289-312.  
[15] SHARMA A M,STAELS B.Review:peroxisome proliferator-activated receptor γ and adipose tissue-understanding obesity-related changes in regulation of lipid and glucose metabolism[J].Journal of Clinical Endocrinology and Metabolism,2007,92(2):386-395.  
[16] FARMER S R.Regulation of PPARγ activity during adipogenesis[J].International Journal of Obesity,2005,29:S13-S16.
[17] KERSTEN S,DESVERGNE B,WAHLI W.Roles of PPARs in health and disease[J].Nature,2000,405(6785):421-424.  
[18] SHIMANO H.Sterol regulatory element-binding proteins (SREBPs):transcriptional regulators of lipid synthetic genes[J].Progress in Lipid Research,2001,40(6):439-452.  
[19] EBERLÉ D,HEGARTY B,BOSSARD P,et al.SREBP transcription factors:master regulators of lipid homeostasis[J].Biochimie,2004,86(11):839-848.  
[20] BERNARD L,LEROUX C,CHILLIARD Y.Expression and nutritional regulation of lipogenic genes in the ruminant lactating mammary gland[J].Advances in Experimental Medicine and Biology,2008,606:67-108.
[21] KIM J B,SPIEGELMAN B M.ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism[J].Genes & Development,1996,10(9):1096-1107.  
[22] KIM J B,WRIGHT H M,WRIGHT M,et al.ADD1/SREBP1 activates PPARγ through the production of endogenous ligand[J].Proceedings of the National Academy of Sciences of the United States of America,1998,95(8):4333-4337.  
[23] GRAUGNARD D E,BERGER L L,FAULKNER D B,et al.High-starch diets induce precocious adipogenic gene network up-regulation in longissimus lumborum of early-weaned Angus cattle[J].British Journal of Nutrition,2010,103(7):953-963.  
[24] LEFTEROVA M I,LAZAR M A.New developments in adipogenesis[J].Trends in Endocrinology & Metabolism,2009,20(3):107-114.  
[25] PICARD F,GUARENIE L.Molecular links between aging and adipose tissue[J].International Journal of Obesity,2005,29(Suppl.1):S36-S39.
[26] FREYTAG S O,PAIELLI D L,GILBERT J D.Ectopic expression of the CCAAT/enhancer-binding protein α promotes the adipogenic program in a variety of mouse fibroblastic cells[J].Genes & Development,1994,8(14):1654-1663.  
[27] MOYNIHAN K A,IMAI S I.Sirt1 as a key regulator orchestrating the response to caloric restriction[J].Drug Discovery Today,2006,3(l):11-17.
[28] QIANG L,WANG L H,KON N,et al.Brown remodeling of white adipose tissue by Sirt1-dependent deacetylation of PPARγ[J].Cell,2012,150(3):620-632.  
[29] CHALKIADAKI A,GUARENTE L.High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction[J].Cell Metabolism,2012,16(2):180-188.  
[30] COSTA C D S,HAMMES T O,ROHDEN F,et al.SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis[J].Obesity Surgery,2010,20(5):633-639.  
[31] GILLUM M P,KOTAS M E,ERION D M,et al.SIRT1 regulates adipose tissue inflammation[J].Diabetes,2010,60(12):3235-3245.
[32] SEALE P,KAJIMURA S,YANG W L,et al.Transcriptional control of brown fat determination by PRDM16[J].Cell Metabolism,2007,6(1):38-54.  
[33] XU C,BAI B,FAN P C,et al.Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice[J].American Journal of Translation Research,2013,5(4):412-426.
[34] ST-PIERRE J,LIN J D,KRAUSS S,et al.Bioenergetic analysis of peroxisome proliferator-activated receptor γ coactivators 1α and 1β (PGC-1α and PGC-1β) in muscle cells[J].Journal of Biological Chemistry,2003,278(29):26597-26603.  
[35] LOUET J F,HAYHURST G,GONZALEZ F J,et al.The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4α and cAMP-response element-binding protein (CREB)[J].Journal of Biological Chemistry,2002,277(41):37991-38000.  
[36] BOUTANT M,JOFFRAUD M,KULKARNI S S,et al.SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function[J].Molecular Metabolism,2015,4(2):118-131.  
[37] BORDONE L,COHEN D,ROBINSON A,et al.SIRT1 transgenic mice show phenotypes resembling calorie restriction[J].Aging Cell,2007,6(6):759-767.  
[38] LI X L,ZANG S W,BLANDER G,et al.SIRT1 deacetylates and positively regulates the nuclear receptor LXR[J].Molecular Cell,2007,28(1):91-106.  
[39] PONUGOTI B,KIM D H,XIAO Z,et al.SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism[J].Journal of Biological Chemistry,2010,285(44):33959-33970.  
[40] RODGERS J T,PUIGSERVER P.Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin1[J].Proceedings of the National Academy of Sciences of the United States of America,2007,104(31):12861-12866.  
[41] WALKER A K,YANG F J,JIANG K R,et al.Conserved role of SIRT1 or thologs in fasting-dependent in hibition of the lipid/cholesterol regulator or SREBP[J].Genes & Development,2010,24(13):1403-1417.  
[42] KEMPER J K,XIAO Z,PONUGOTI B,et al.FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states[J].Cell Metabolism,2009,10(5):392-404.  
[43] PURUSHOTHAM A,XU Q,LU J,et al.Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice[J].Molecular and Cellular Biology,2012,32(7):1226-1236.  
[44] KALAANY N Y,MANGELSDORF D J.LXRS and FXR:the yin and yang of cholesterol and fat metabolism[J].Annual Review of Physiology,2006,68(1):159-191.  
[45] GUARENTE L.Sirtuins,aging,and medicine[J].The New England Journal of Medicine,2011,364(23):2235-2244.  
[46] KITADA M,KUME S,TAKEDA-WATANABE A,et al.Sirtuins and renal diseases:relationship with aging and diabetic nephropathy[J].Clinical Science,2013,124(3):153-164.  
[47] HOU X Y,XU S Q,MAITLAND-TOOLAN K A,et al.SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase[J].Journal of Biological Chemistry,2008,283(29):20015-20026.  
[48] STEINBERG G R,KEMP B E.AMPK in health and disease[J].Physiological Reviews,2009,89(3):1025-1078.  
[49] CANTÓ C,GERHART-HINES Z,FEIGE Z N,et al.AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity[J].Nature,2009,458(7241):1056-1060.  
[50] CARLING D,ZAMMIT V A,HARDIE D G.A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis[J].FEBS Letters,1987,223(2):217-222.  
[51] HARDIE D G,CARLING D,CARLSON M.The AMP-activated/SNF1 protein kinase subfamily:metabolic sensors of the eukaryotic cell[J].Annual Review of Biochemistry,1998,67(1):821-855.  
[52] LASS A,ZIMMERMANN R,OBERER M,et al.Lipolysis-a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores[J].Progress in Lipid Research,2011,50(1):14-27.  
[53] CHAKRABARTI P,KANDROR K V.FoxO1 controls insulindependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes[J].Journal of Biological Chemistry,2009,284 (20):13296-13300.
[54] CHENG Z Y,WHITE M F.Targeting Forkhead box O1 from the concept to metabolic diseases:lessons from mouse models[J].Antioxidants & Redox Signaling,2011,14(4):649-661.  
[55] LOMB D J,LAURENT G,HAIGIS M C.Sirtuins regulate key aspects of lipid metabolism[J].Biochimica et Biophysica Acta:Proteins and Proteomics,2010,1804(8):1652-1657.  
[56] CHAKRABARTI P,ENGLISH T,KARKI S,et al.SIRT1 controls lipolysis in adipocytes via FoxO1-mediated expression of ATGL[J].Journal of Lipid Research,2011,52(9):1693-1701.  
[57] CHEN W L,KANG C H,WANG S G,et al.α-lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase[J].Diabetologia,2012,55(6):1824-1835.  
[58] HUANG C H,SHIN S M,WU M T,et al.Monacolin K affects lipid metabolism through SIRT1/AMPK pathway in HepG2 cells[J].Archives of Pharmacal Research,2013,36(12):1541-1551.  
[59] HENIN N,VINCENT M F,GRUBER H E,et al.Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase[J].FASEB Journal,1995,9(7):541-546.
[60] ENDO A,HASUMI K.Biochemical aspect of HMG CoA reductase inhibitors[J].Advances in Enzyme Regulation,1989,28:53-64.
[61] MANNING B D,CANTLEY L C.AKT/PKB signaling:navigating downstream[J].Cell,2007,129(7):1261-1274.  
[62] HORTON J D,GOLDSTEIN J L,BROWN M S.SREBPs:activators of the complete program of cholesterol and fatty acid synthesis in the liver[J].Journal of Clinical Investigation,2002,109(9):1125-1131.  
[63] PORSTMANN T,GRIFFITHS B,CHUNG Y L,et al.PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP[J].Oncogene,2005,24(43):6465-6481.
[64] DVVEL K,YECIES J L,MENON S,et al.Activation of a metabolic gene regulatory network downstream of mTOR complex 1[J].Molecular Cell,2010,39(2):171-183.  
[65] PORSTMANN T,SANTOS C R,GRIFFITHS B,et al.SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth[J].Cell Metabolism,2008,8(3):224-236.  
[66] YEH W C,BIERER B E,MCKNIGHT S L.Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells[J].Proceedings of the National Academy of Sciences of the United States of America,1995,92(24):11086-11090.  
[67] ROSEN E D,HSU C H,WANG X,et al.C/EBPα induces adipogenesis through PPARγ:a unified pathway[J].Genes & Development,2002,16(1):22-26.  
[68] ZHANG H H,HUANG J X,DVVEL K,et al.Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway[J].PLoS One,2009,4(7):e6189.
[69] POLAK P,CYBULSKI N,FEIGE J N,et al.Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration[J].Cell Metabolism,2008,8(5):399-410.  
[70] KIM J E,CHEN J.Regulation of peroxisome proliferator-activated receptor-γ activity by mammalian target of rapamycin and amino acids in adipogenesis[J].Diabetes,2004,53(11):2748-2756.  
[71] YU W H,CHEN Z G,ZHANG J L,et al.Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells[J].Molecular and Cellular Biochemstry,2008,310(1/2):11-18.
[72] EL-CHAÂR D,GAGNON A,SORISKY A.Inhibition of insulin signaling and adipogenesis by rapamycin:effect on phosphorylation of p70 S6 kinase vs eIF4E-BP1[J].International Journal of Obesity,2004,28(2):191-198
[73] LE BACQUER O,PETROULAKIS E,PAGLIALUNGA S,et al.Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2[J].Journal of Clinical Investigation,2007,117(2):387-396.  
[74] LAPLANTE M,HORVAT S,FESTUCCIA W T,et al.DEPTOR cell-autonomously promotes adipogenesis,and its expression is associated with obesity[J].Cell Metabolism,2012,16(2):202-212.  
[75] CHAKRABARTI P,ENGLISH T,SHI J,et al.Mammalian target of rapamycin complex 1 suppresses lipolysis stimulates lipogenesis and promotes fat storage[J].Diabetes,2010,59(4):775-781.  
[76] SOLIMAN G A,ACOSTA-JAQUEZ H A,FINGAR D C.mTORC1 inhibition via rapamycin promotes triacylglycerol lipolysis and release of free fatty acids in 3T3-L1 adipocytes[J].Lipids,2010,45(12):1089-1100.  
[77] KUMAR A,LAWRENCE J C,Jr.,JUNG D Y,et al.Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism[J].Diabetes,2010,59(6):1397-1406.  
[78] WANG H,ECKEL R H.Lipoprotein lipase:from gene to obesity[J].American Journal of Physiology:Endocrinology and Metabolism,2009,297(2):E271-E288.
[79] UM S H,FRIGERIO F,WATANABE M,et al.Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity[J].Nature,2004,431(7005):200-205.  
[80] HAY N,SONENBERG N.Upstream and downstream of mTOR[J].Genes & Development,2004,18(16):1926-1945.  
[81] WULLSCHLEGER S,LOEWITH R,HALL M N.TOR signaling in growth and metabolism[J].Cell,2006,124(3):471-484.  
[82] GHOSH H S,MCBURNEY M,ROBBINS P D.SIRT1 negatively regulates the mammalian target of rapamycin[J].PLoS One,2010,5(2):e9199.
[83] 赵涛涛,赵霞,景旭斌,等.雷帕霉素靶蛋白(mTOR)信号通路参与沉默信息调节因子1(Sirt1)抑制小鼠脂肪沉积[J].农业生物技术学报,2012,20(4):404-410.
Outlines

/