Molecular Mechanisms in Regulation of Milk Protein Synthesis by Amino Acids in Mammary Gland

ZHANG Muchen; GAO Haina; ZHAO Shengguo; WANG Shanshan; ZHENG Nan; WANG Jiaqi

doi:10.3969/j.issn.1006-267x.2016.05.004

Chinese Journal of Animal Nutrition >

2016 , Vol. 28 >Issue 5: 1309 - 1316

DOI: https://doi.org/10.3969/j.issn.1006-267x.2016.05.004

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Molecular Mechanisms in Regulation of Milk Protein Synthesis by Amino Acids in Mammary Gland

ZHANG Muchen ,
GAO Haina ,
ZHAO Shengguo ,
WANG Shanshan ,
ZHENG Nan ,
WANG Jiaqi

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1. Ministry of Agriculture-Milk Risk Assessment Laboratory, Ministry of Agriculture-Milk and Dairy Product Inspection Center, State Key Laboratory of Animal Nutrition, Institute of Animal Science, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
2. College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China;
3. College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China

Received date: 2015-12-01

Online published: 2016-05-24

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Abstract

As an important ‘biological factory’ to maintain life activities of mammalian, the mammary gland utilizes nutrients, such as amino acids, that uptake from blood as substrates to synthesize milk protein. Studies confirmed that amino acids also can be used as a signal factor to regulate milk protein gene transcription and translation through the signaling cascade pathways in the mammary gland, which affects milk protein synthesis. Janus kinase-signal transducer and activator of transcription (JAK-STAT) and mammalian target of rapamycin (mTOR) signaling pathways are the main regulatory pathways in the process of milk protein gene transcription and translation. The molecular mechanism of the JAK-STAT and mTOR signaling pathways in the mammary gland and research progress on regulation of milk protein synthesis by amino acids through these pathways were reviewed in this paper, with the aim to further clarify the mechanism in regulation of milk protein synthesis by amino acids.

Key words： amino acid; milk protein; regulation; JAK-STAT; mTOR

Cite this article

ZHANG Muchen , GAO Haina , ZHAO Shengguo , WANG Shanshan , ZHENG Nan , WANG Jiaqi . Molecular Mechanisms in Regulation of Milk Protein Synthesis by Amino Acids in Mammary Gland[J]. Chinese Journal of Animal Nutrition, 2016 , 28(5) : 1309 -1316 . DOI: 10.3969/j.issn.1006-267x.2016.05.004

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