[1] STEPPAN C M,BAILEY S T,BHAT S,et al.The hormone resistin links obesity to diabetes[J].Nature,2001,409(6818):307-312.

[2] 赵伟利,薛昌斌,高磊,等.绵羊抵抗素基因(
RETN)克隆、序列分析及其在饥饿模型中的表达变化规律[J].农业生物技术学报,2015,23(8):981-990.
[3] 于健,邹迪莎,叶瑶,等.巴马小型猪T2DM模型胰岛素抵抗及瘦素、抵抗素水平的变化[J].山东医药,2015,55(5):10-12.
[4] CHEN X D,LEI T,XIA T,et al.Increased expression of resistin and tumour necrosis factor-α in pig adipose tissue as well as effect of feeding treatment on resistin and cAMP pathway[J].Diabetes,Obesity and Metabolism,2004,6(4):271-279.

[5] 王娅,黄文华,邓俊良,等.重组牛抵抗素对鼠血糖和胰岛素含量的影响[J].中国兽医学报,2015,35(6):949-952.
[6] PANG S S,LE Y Y.Role of Resistin in inflammation and inflammation-related diseases[J].Cellular & Molecular Immunology,2006,3(1):29-34.
[7] LEE B C,LEE J.Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance[J].Biochimica et Biophysica Acta::Molecular Basis of Disease,2014,1842(3):446-462.

[8] QATANANI M,SZWERGOLD N R,GREAVES D R,et al.Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice[J].Journal of Clinical Investigation,2009,119(3):531-539.

[9] KANDA H,TATEYA S,TAMORI Y,et al.MCP-1 contributes to macrophage infiltration into adipose tissue,insulin resistance,and hepatic steatosis in obesity[J].Journal of Clinical Investigation,2006,116(6):1494-1505.

[10] VERMA S,LI S H,WANG C H,et al.Resistin promotes endothelial cell activation further evidence of adipokine-endothelial interaction[J].Circulation,2003,108(6):736-740.

[11] PIRVULESCU M M,GAN A M,STAN D,et al.Subendothelial resistin enhances monocyte transmigration in a co-culture of human endothelial and smooth muscle cells by mechanisms involving fractalkine,MCP-1 and activation of TLR4 and Gi/o proteins signaling[J].The International Journal of Biochemistry & Cell Biology,2014,50:29-37.
[12] WALCHER D,HESS K,BERGER R,et al.Resistin:a newly identified chemokine for human CD4-positive lymphocytes[J].Cardiovascular Research,2010,85(1):167-174.

[13] CHINETTI-GBAGUIDI G,STAELS B.Macrophages in obesity and insulin resistance[M]//BISWAS S K,MANTOVANI A.Macrophages:biology and role in the pathology of diseases.New York:Springer,2014:375-385.
[14] LI P P,LU M,NGUYEN M T A,et al.Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice[J].Journal of Biological Chemistry,2010,285(20):15333-15345.

[15] WENTWORTH J M,NASELLI G,BROWN W A,et al.Pro-inflammatory CD11c
+CD206
+ adipose tissue macrophages are associated with insulin resistance in human obesity[J].Diabetes,2010,59(7):1648-1656.

[16] SILSWAL N,SINGH A K,ARUNA B,et al.Human resistin stimulates the pro-inflammatory cytokines TNF-α and IL-12 in macrophages by NF-κB-dependent pathway[J].Biochemical and Biophysical Research Communications,2005,334(4):1092-1101.

[17] LEE S,LEE H C,KWON Y W,et al.Adenylyl cyclase-associated protein 1 is a receptor for human resistin and mediates inflammatory actions of human monocytes[J].Cell Metabolism,2014,19(3):484-497.

[18] FU Y C,LUO L H,LUO N L,et al.Proinflammatory cytokine production and insulin sensitivity regulated by overexpression of resistin in 3T3-L1 adipocytes[J].Nutrition & Metabolism,2006,3:28.
[19] ELGAZAR-CARMON V,RUDICH A,HADAD N,et al.Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding[J].Journal of Lipid Research,2008,49(9):1894-1903.

[20] BOSTRÖM E A,TARKOWSKI A,BOKAREWA M.Resistin is stored in neutrophil granules being released upon challenge with inflammatory stimuli[J].Biochimica et Biophysica Acta:Molecular Cell Research,2009,1793(12):1894-1900.

[21] 高振秋,张巧,徐彤,等.嗜中性粒细胞是人抵抗素表达的主要细胞[J].中国生物化学与分子生物学报,2011,27(1):48-54.
[22] 杜琳敏.慢性炎症致C57BL/6J小鼠糖代谢紊乱及其相关分子机制的研究[D].硕士学位论文.重庆:重庆医科大学,2013.
[23] EDWARDS C R,HINDLE A K,LATHAM P S,et al.Resistin expression correlates with steatohepatitis in morbidly obese patients[J].Surgical Endoscopy,2013,27(4):1310-1314.

[24] 吴佩娴,蓝薇,张帆,等.非酒精性脂肪性肝病中抵抗素和肝纤维化的关系[J].中国医师杂志,2014,16(4):482-484.
[25] 侯鹏高,吕长淮.抵抗素与非酒精性脂肪肝病相关性研究[J].包头医学院学报,2015,31(6):25-26.
[26] 赵彩彦,闫蕾,王亚东,等.非酒精性脂肪性肝炎发病中抵抗素对肝细胞的致炎作用[J].中华肝脏病杂志,2009,17(9):683-687.
[27] BERTOLANI C,SANCHO-BRU P,FAILLI P,et al.Resistin as an intrahepatic cytokine:overexpression during chronic injury and induction of proinflammatory actions in hepatic stellate cells[J].The American Journal of Pathology,2006,169(6):2042-2053.

[28] SINGHAL N S,LAZAR M A,AHIMA R S.Central resistin induces hepatic insulin resistance via neuropeptide Y[J].The Journal of Neuroscience,2007,27(47):12924-12932.

[29] PARK H K,QATANANI M,BRIGGS E R,et al.Inflammatory induction of human resistin causes insulin resistance in endotoxemic mice[J].Diabetes,2011,60(3):775-783.

[30] WIESER V,MOSCHEN A R,TILG H.Inflammation,cytokines and insulin resistance:a clinical perspective[J].Archivum Immunologiae et Therapiae Experimentalis,2013,61(2):119-125.

[31] ZHOU X L,YOUS Y.Rosiglitazone inhibits hepatic insulin resistance induced by chronic pancreatitis and
IKK-β/
NF-κB expression in liver[J].Pancreas,2014,43(8):1291-1298.

[32] LUO T J,WANG K Z,ZHAO W W,et al.Modified Si-Miao-San (四妙散加减) regulates adipokine expression and ameliorates insulin resistance by targeting IKKβ/insulin receptor substrate-1 in mice[J].Chinese Journal of Integrative Medicine,2014,doi:10.1007/s11655-014-1802-x.
[33] 张芸.抵抗素诱导人冠状动脉内皮细胞通过NF-κB依赖的通路生成组织因子[J].中国病理生理杂志,2010(9):1832.
[34] ZHANG Z J,ZHANG Z Q,KANG Y,et al.Resistin stimulates expression of chemokine genes in chondrocytes via combinatorial regulation of C/EBPβ and NF-κB[J].International Journal of Molecular Sciences,2014,15(10):17242-17255.

[35] 朱良荣,管小琴,祁明美,等.抵抗素在非酒精性脂肪肝大鼠胰岛素抵抗中的作用[J].中国生物制品学杂志,2012,25(2):185-189.
[36] 张健.Resistin对炎症信号途径的调控研究[D].博士学位论文.武汉:华中农业大学,2010.
[37] TARKOWSKI A,BJERSING J,SHESTAKOV A,et al.Resistin competes with lipopolysaccharide for binding to toll-like receptor 4[J].Journal of Cellular and Molecular Medicine,2010,14(6b):1419-1431.
[38] HAN M S,JUNG D Y,MOREL C,et al.
JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation[J].Science,2013,339(6116):218-222.

[39] KUSMINSKI C M,DA SILVA N F,CREELY S J,et al.The
in vitro effects of resistin on the innate immune signaling pathway in isolated human subcutaneous adipocytes[J].The Journal of Clinical Endocrinology and Metabolism,2007,92(1):270-276.

[40] BENOMAR Y,GERTLER A,De LACY P,et al.Central resistin overexposure induces insulin resistance through Toll-like receptor 4[J].Diabetes,2013,62(1):102-114.