[1] CHEN W,XIA Y P,CHEN W J,et al.Improvement of myocardial glycolipid metabolic disorder in diabetic hamster with
Astragalus polysaccharides treatment[J].Molecular Biology Reports,2012,39(7):7609-7615.
[2] HE X J,SHU J,XU L,et al.Inhibitory effect of
Astragalus polysaccharides on lipopolysaccharide-induced TNF-a and IL-1β production in THP-1 cells[J].Molecules,2012,17(3):3155-3164.
[3] WANG X F,LI Y L,YANG X J,et al.
Astragalus polysaccharide reduces inflammatory response by decreasing permeability of LPS-infected Caco2 cells[J].International Journal of Biological Macromolecules,2013,61:347-352.
[4] ZHANG G G,YANG Z B,WANG Y,et al.Effects of
Astragalus membranaceus root processed to different particle sizes on growth performance,antioxidant status,and serum metabolites of broiler chickens[J].Poultry Science,2013,92(1):178-183.
[5] ZUO Z Y,YANG W R,WANG Y,et al.Effects of
Astragalus membranaceus on laying performance and antioxidant status of laying hens[J].The Journal of Applied Poultry Research,2012,21(2):243-250.
[6] ZHU Z Y,LIU R Q,SI C L,et al.Structural analysis and anti-tumor activity comparison of polysaccharides from
Astragalus[J].Carbohydrate Polymers,2011,85(4):895-902.
[7] SUN S Y,ZHENG K,ZHAO H Y,et al.Regulatory effect of
Astragalus polysaccharides on intestinal intraepithelial γδT cells of tumor bearing mice[J].Molecules,2014,19(9):15224-15236.
[8] ABUELSAAD A S A.Supplementation with
Astragalus polysaccharides alters
Aeromonas-induced tissue-specific cellular immune response[J].Microbial Pathogenesis,2014,66:48-56.
[9] GUIL S,ESTELLER M.RNA-RNA interactions in gene regulation:the coding and noncoding players[J].Trends in Biochemical Sciences,2015,40(5):248-256.
[10] ROSS S A,DAVIS C D.The emerging role of microRNAs and nutrition in modulating health and disease[J].Annual Review of Nutrition,2014,34(1):305-336.
[11] LIANG Y,RIDZON D,WONG L,et al.Characterization of microRNA expression profiles in normal human tissues[J].BMC Genomics,2007,8(1):166-185.
[12] BUSHATI N,COHENS M.MicroRNA functions[J].Annual Review of Cell and Developmental Biology,2007,23(1):175-205.
[13] XIAO C C,RAJEWSKY K.MicroRNA control in the immune system:basic principles[J].Cell,2009,136(1):26-36.
[14] TÜFEKCI K U,MEUWISSEN R L J,GENÇŞ.The role of microRNAs in biological processes[M]//YOUSEF M,ALLMER J.miRNomics:microRNA biology and computational analysis.New York:Humana Press,2014:15-31.
[15] LEE H M,NGUYEN D T,LU L F.Progress and challenge of microRNA research in immunity[J].Frontiers in Genetics,2014,5:178.
[16] KAPPIL M,CHEN J.Environmental influence of microRNA in children's health[J].Current Opinion in Pediatrics,2014,26(2):243-251.
[17] HARRYANTO H.Role of microRNA in early life placental programming of insulin resistance and metabolic health[D].Ph.D.Thesis.Adelaide:The University of Adelaide,2014.
[18] MOBARRA N,SHAFIEE A,RAD S M A H,et al.Overexpression of microRNA-16 declines cellular growth,proliferation and induces apoptosis in human breast cancer cells[J].
In Vitro Cellular & Developmental Biology:Animal,2015, 51(6):604-611.
[19] YANG T Q,LU X J,WU T F,et al.MicroRNA-16 inhibits glioma cell growth and invasion through suppression of BCL2 and the nuclear factor-κB1/MMP9 signaling pathway[J].Cancer Science,2014,105(3):265-271.
[20] HUANG E Y,LIU R H,CHU Y W.miRNA-15a/16:as tumor suppressors and more[J].Future Oncology,2015,11(16):2351-2363.
[21] ZHOU R,LI X Q,HU G K,et al.miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 gene[J].PLoS One,2012,7(1):e30772.
[22] LI T,MORGAN M J,CHOKSI S,et al.MicroRNAs modulate the noncanonical transcription factor NF-κB pathway by regulating expression of the kinase IKKα during macrophage differentiation[J].Nature Immunology,2010,11(9):799-805.
[23] CALIN G A,CIMMINO A,FABBRI M,et al.MiR-15a and miR-16-1 cluster functions in human leukemia[J].Proceedings of the National Academy of Sciences of the Unites States of America,2008,105(13):5166-5171.
[24] TALARI M,KAPADIA B,KAIN V,et al.MicroRNA-16 modulates macrophage polarization leading to improved insulin sensitivity in myoblasts[J].Biochimie,2015,119:16-26.
[25] 李玉龙.APS调控种公鸡基因传代转录分析[D].硕士学位论文.杨凌:西北农林科技大学,2015.
[26] LIU J,LIANG P,YIN C,et al.Effects of several Chinese herbal aqueous extracts on human sperm motility
in vitro[J].Andrologia,2004,36(2):78-83.
[27] KIM W,KIM S H,PARK S K,et al.
Astragalus membranaceus ameliorates reproductive toxicity induced by cyclophosphamide in male mice[J].Phytotherapy Research,2012,26(9):1418-1421.
[28] CHEN C F,RIDZON D A,BROOMER A J,et al.Real-time quantification of microRNAs by stem-loop RT-PCR[J].Nucleic Acids Research,2005,33(20):e179.
[29] SMALL E M,OLSON E N.Pervasive roles of microRNAs in cardiovascular biology[J].Nature,2011,469(7330):336-342.
[30] YUE J M,TIGYI G.Conservation of miR-15a/16-1 and miR-15b/16-2 clusters[J].Mammalian Genome,2010,21(1/2):88-94.
[31] LIANG Y,RIDZON D,WONG L,et al.Characterization of microRNA expression profiles in normal human tissues[J].BMC Genomics,2007,8(1):166.
[32] CASAS-AGUSTENCH P,FERNANDES F S,TAVARES DO CARMO M G,et al.Consumption of distinct dietary lipids during early pregnancy differentially modulates the expression of microRNAs in mothers and offspring[J].PLoS One,2015,10(2):e0117858.
[33] MEALE S J,ROMAO J M,HE M L,et al.Effect of diet on microRNA expression in ovine subcutaneous and visceral adipose tissues[J].Journal of Animal Science,2014,92(8):3328-3337.
[34] ROMAO J M,JIN W,HE M L,et al.Altered microRNA expression in bovine subcutaneous and visceral adipose tissues from cattle under different diet[J].PLoS One,2012,7(7):e40605.
[35] YANG J,CAO Y X,SUN J F,et al.Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells[J].Medical Oncology,2010,27(4):1114-1118.
[36] GAO S M,YANG J J,CHEN C Q,et al.Pure curcumin decreases the expression of WT1 by upregulation of miR-15a and miR-16-1 in leukemic cells[J].Journal of Experimental & Clinical Cancer Research,2012,31(1):27.
[37] TSANG W P,KWOKT T.Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells[J].The Journal of Nutritional Biochemistry,2010,21(2):140-146.
[38] YUAN C T,PAN X P,GONG Y,et al.Effects of
Astragalus polysaccharides (APS) on the expression of immune response genes in head kidney,gill and spleen of the common carp,
Cyprinus carpio L.[J].International Immunopharmacology,2008,8(1):51-58.
[39] LIU L,SHEN J,ZHAO C,et al.Dietary
Astragalus polysaccharide alleviated immunological stress in broilers exposed to lipopolysaccharide[J].International Journal of Biological Macromolecules,2015,72:624-632.
[40] ZHANG M,NII T,ISOBE N,et al.Expression of Toll-like receptors and effects of lipopolysaccharide on the expression of proinflammatory cytokines and chemokine in the testis and epididymis of roosters[J].Poultry Science,2012,91(8):1997-2003.
[41] ZHANG C L,REN H J,LIU M M,et al.Modulation of intestinal epithelial cell proliferation,migration,and differentiation
in vitro by
Astragalus polysaccharides[J].PLoS One,2014,9(8):e106674.
[42] WANG X F,SHEN J,LI S Z,et al.Sulfated
Astragalus polysaccharide regulates the inflammatory reaction in LPS-infected broiler chicks[J].International Journal of Biological Macromolecules,2014,69:146-150.
[43] WANG X F,WANG S Y,LI Y L,et al.Sulfated
Astragalus polysaccharide can regulate the inflammatory reaction induced by LPS in Caco2 cells[J].International Journal of Biological Macromolecules,2013,60:248-252.
[44] SHI J J,ZHAO Y,WANG Y P,et al.Inflammatory caspases are innate immune receptors for intracellular LPS[J].Nature,2014,514(7521):187-192.
[45] BARTEL D P.MicroRNAs:target recognition and regulatory functions[J].Cell,2009,136(2):215-233.
[46] SALTIEL A R,PESSIN J E.Insulin signaling pathways in time and space[J].Trends in Cell Biology,2002,12(2):65-71.
[47] JING Q,HUANG S,GUTH S,et al.Involvement of microRNA in AU-rich element-mediated mRNA instability[J].Cell,2005,120(5):623-634.
[48] ANDERSON P.Post-transcriptional control of cytokine production[J].Nature Immunology,2008,9(4):353-359.
[49] HUANG Z,MA J T,CHEN M J,et al.Dual TNF-α/IL-12p40 interference as a strategy to protect against colitis based on miR-16 precursors with macrophage targeting vectors[J].Molecular Therapy,2015,23(10):1611-1621.
[50] WANG X L,WANG X L,LIU X L,et al.miR-15a/16 are upreuglated in the serum of neonatal sepsis patients and inhibit the LPS-induced inflammatory pathway[J].International Journal of Clinical and Experimental Medicine,2015,8(4):5683-5690.
[51] ZHANG X H,WANG D Y,HU Y L,et al.Immunologic enhancement of
Astragalus polysaccharide (APS) on the humoral immunity of chicken[J].Chinese Journal of Veterinary Science,2009,29(3):312-314,334.
