ZHOU Jian , XIONG Xia , LI Jianzhong , DENG Baichuan , HUANG Pengfei , YIN Yulong . Mechanisms and Effects of Milk-Derived Bioactive Peptides on Intestinal Functions of Animals[J]. Chinese Journal of Animal Nutrition, 2016 , 28(7) : 1981 -1987 . DOI: 10.3969/j.issn.1006-267x.2016.07.002

[1] GILBERT E R,WONG E A,WEBB K E,Jr.Board-invited review:peptide absorption and utilization:implications for animal nutrition and health[J].Journal of Animal Science,2008,86(9):2135-2155.  
[2] KITTS D D,WEILER K.Bioactive proteins and peptides from food sources.Applications of bioprocesses used in isolation and recovery[J].Current Pharmaceutical Design,2003,9(16):1309-1323.  
[3] KORHONEN H,PIHLANTO A.Bioactive peptides:production and functionality[J].International Dairy Journal,2006,16(9):945-960.  
[4] NAGPAL R,BEHARE P,RANA R,et al.Bioactive peptides derived from milk proteins and their health beneficial potentials:an update[J].Food & Function,2011,2(1):18-27.  
[5] SPANIER B.Transcriptional and functional regulation of the intestinal peptide transporter PEPT1[J].The Journal of Physiology,2014,592(5):871-879.  
[6] 贺光祖,谭碧娥,肖昊,等.肠道小肽吸收利用机制及其营养功能[J].动物营养学报,2015,27(4):1047-1054.
[7] VIJ R,REDDI S,KAPILA S,et al.Transepithelial transport of milk derived bioactive peptide VLPVPQK[J].Food Chemistry,2016,190:681-688.
[8] DALMASSO G,THI THU NGUYEN H,YAN Y T,et al.MicroRNA-92b regulates expression of the oligopeptide transporter PepT1 in intestinal epithelial cells[J].American Journal of Physiology Gastrointestinal & Liver Physiology,2011,300(1):G52-G59.
[9] DANIEL H,KOTTRA G.The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology[J].Pflügers Archiv,2004,447(5):610-618.
[10] WARSI J,DONG L,ELVIRA B,et al.SPAK dependent regulation of peptide transporters PEPT1 and PEPT2[J].Kidney & Blood Pressure Research,2014,39(4):388-398.  
[11] WARSI J,ELVIRA B,BISSINGER R,et al.Downregulation of peptide transporters PEPT1 and PEPT2 by oxidative stress responsive kinase OSR1[J].Kidney & Blood Pressure Research,2014,39(6):591-599.  
[12] HAN D N,ZHANG D H,WANG L P,et al.Protective effect of β-casomorphin-7 on cardiomyopathy of streptozotocin-induced diabetic rats via inhibition of hyperglycemia and oxidative stress[J].Peptides,2013,44:120-126.
[13] YIN H,MIAO J F,ZHANG Y S.Protective effect of β-casomorphin-7 on type 1 diabetes rats induced with streptozotocin[J].Peptides,2010,31(9):1725-1729.  
[14] ZOGHBI S,TROMPETTE A,CLAUSTRE J,et al.β-casomorphin-7 regulates the secretion and expression of gastrointestinal mucins through a μ-opioid pathway[J].American Journal of Physiology Gastrointestinal and Liver Physiology,2006,290(6):G1105-G1113.
[15] ZHANG W,SONG S X,LIU F,et al.Beta-casomorphin-7 prevents epithelial-mesenchymal transdifferentiation of NRK-52E cells at high glucose level:involvement of AngⅡ-TGF-β1 pathway[J].Peptides,2015,70:37-44.
[16] DALZIEL J E,SPENCER N J,DUNSTAN K E,et al.An in vitro rat model of colonic motility to determine the effect of β-casomorphin-5 on propagating contractions[J].Food & Function,2014,5(11):2768-2774.  
[17] TIDONA F,CRISCIONE A,GUASTELLA A,et al.Bioactive peptides in dairy products[J].Italian Journal of Animal Science,2009,8(3):315-340.
[18] GARCÍA-NEBOT M J,BARBERÁ R,ALEGRÍA A.Iron and zinc bioavailability in Caco-2 cells:influence of caseinophosphopeptides[J].Food Chemistry,2013,138(2/3):1298-1303.
[19] GARCíA-NEBOT M J,ALEGRíA A,BARBERá R,et al.Effect of caseinophosphopeptides from αs- and β-casein on iron bioavailability in HuH7 cells[J].Journal of Agricultural and Food Chemistry,2015,63(30):6757-6763.  
[20] BOUTROU R,COIRRE E,JARDIN J,et al.Phosphorylation and coordination bond of mineral inhibit the hydrolysis of the β-casein (1-25) peptide by intestinal brush-border membrane enzymes[J].Journal of Agricultural and Food Chemistry,2010,58(13):7955-7961.  
[21] 李垚,李玲,苏全,等.小肽螯合铜、铁、锰、锌、硒对仔猪生长性能及代谢影响[J].东北农业大学学报,2016,47(2):46-53.
[22] MEJáRE M,BüLOW L.Metal-binding proteins and peptides in bioremediation and phytoremediation of heavy metals[J].Trends in Biotechnology,2001,19(2):67-73.  
[23] BHATTACHARYYA A,CHATTOPADHYAY R,MITRA S,et al.Oxidative stress:an essential factor in the pathogenesis of gastrointestinal mucosal diseases[J].Physiological Reviews,2014,94(2):329-354.  
[24] CAI X,CHEN X L,WANG X C,et al.Pre-protective effect of lipoic acid on injury induced by H₂O₂ in IPEC-J2 cells[J].Molecular and Cellular Biochemistry,2013,378(1/2):73-81.
[25] ZHU L H,ZHAO K L,CHEN X L,et al.Impact of weaning and an antioxidant blend on intestinal barrier function and antioxidant status in pigs[J].Journal of Animal Science,2012,90(8):2581-2589.  
[26] WEBER C.IBD:lactococcus lactis alleviates oxidative stress and colitis in mice[J].Nature Reviews Gastroenterology & Hepatology,2015,12(8):429.
[27] ZHANG Q X,JIN M M,ZHANG L,et al.Hydrophobicity of whey protein hydrolysates enhances the protective effect against oxidative damage on PC 12 cells[J].Journal of Dairy Research,2015,82(1):1-7.  
[28] RIVAL S G,FORNAROLI S,BOERIU C G,et al.Caseins and casein hydrolysates.1.Lipoxygenase inhibitory properties[J].Journal of Agricultural and Food Chemistry,2001,49(1):287-294.  
[29] CHEISON S C,WANG Z,XU S Y.Preparation of whey protein hydrolysates using a single-and two-stage enzymatic membrane reactor and their immunological and antioxidant properties:characterization by multivariate data analysis[J].Journal of Agricultural and Food Chemistry,2007,55(10):3896-3904.  
[30] SILVA S V,MALCATA F X.Caseins as source of bioactive peptides[J].International Dairy Journal,2005,15(1):1-15.  
[31] BHAT Z F,KUMAR S,BHAT H F.Bioactive peptides of animal origin:a review[J].Journal of Food Science and Technology,2015,52(9):5377-5392.  
[32] PEÑA-RAMOS E A,XIONG Y L,ARTEAGA G E.Fractionation and characterisation for antioxidant activity of hydrolysed whey protein[J].Journal of the Science of Food and Agriculture,2004,84(14):1908-1918.  
[33] HOOPER L V,LITTMAN D R,MACPHERSON A J.Interactions between the microbiota and the immune system[J].Science,2012,336(6086):1268-1273.  
[34] CHOI M K,LE M T,NGUYEN D T,et al.Genome-level identification,gene expression,and comparative analysis of porcine β-defensin genes[J].BMC Genetics,2012,13(1):98.
[35] MATHEW A G,SUTTON A L,SCHEIDT A B,et al.Effect of galactan on selected microbial populations and pH and volatile fatty acids in the ileum of the weanling pig[J].Journal of Animal Science,1993,71(6):1503-1509.
[36] KERMAN D H,DESHPANDE A R.Gut microbiota and inflammatory bowel disease:the role of antibiotics in disease management[J].Postgraduate Medicine,2014,126(4):7-19.  
[37] MUKIZA C N,DUBREUIL J D.Escherichia coli heat-stable toxin b impairs intestinal epithelial barrier function by altering tight junction proteins[J].Infection and Immunity,2013,81(8):2819-2827.  
[38] ROSELLI M,FINAMORE A,BRITTI M S,et al.The novel porcine Lactobacillus sobrius strain protects intestinal cells from enterotoxigenic Escherichia coli K88 infection and prevents membrane barrier damage[J].The Journal of Nutrition,2007,137(12):2709-2716.
[39] JOHNSON A M,KAUSHIK R S,ROTELLA N J,et al.Enterotoxigenic Escherichia coli modulates host intestinal cell membrane asymmetry and metabolic activity[J].Infection and Immunity,2009,77(1):341-347.  
[40] Otvos L,Jr.The Short proline-rich antibacterial peptide family[J].Cellular and Molecular Life Sciences,2002,59(7):1138-1150.  
[41] GOBBETTI M,MINERVINI F,RIZZELLO C G.Angiotensin Ⅰ-converting-enzyme-inhibitory and antimicrobial bioactive peptides[J].International Journal of Dairy Technology,2004,57(2/3):173-188.
[42] RYDLO T,MILTZ J,MOR A.Eukaryotic antimicrobial peptides:promises and premises in food safety[J].Journal of Food Science,2006,71(9):R125-R135.
[43] ZHOU N,TIELEMAN P,VOGEL H J.Molecular dynamics simulations of bovine lactoferricin:turning a helix into a sheet[J].Biometals,2004,17(3):217-223.  
[44] YOON J H,INGALE S L,KIM J S,et al.Effects of dietary supplementation with antimicrobial peptide-P5 on growth performance,apparent total tract digestibility,faecal and intestinal microflora and intestinal morphology of weanling pigs[J].Journal of the Science of Food and Agriculture,2013,93(3):587-592.  
[45] JIANG Z Y,SUN L H,LIN Y C,et al.Effects of dietary glycyl-glutamine on growth performance,small intestinal integrity,and immune responses of weaning piglets challenged with lipopolysaccharide[J].Journal of Animal Science,2009,87(12):4050-4056.  
[46] REDDY K V R,YEDERY R D,ARANHA C.Antimicrobial peptides:premises and promises[J].International Journal of Antimicrobial Agents,2004,24(6):536-547.  
[47] HUANG H W.Free energies of molecular bound states in lipid bilayers:lethal concentrations of antimicrobial peptides[J].Biophysical Journal,2009,96(8):3263-3272.  
[48] OWENS B M J,SIMMONS A.Intestinal stromal cells in mucosal immunity and homeostasis[J].Mucosal Immunology,2013,6(2):224-234.  
[49] GAUTHIER S F,POULIOT Y,SAINT-SAUVEUR D.Immunomodulatory peptides obtained by the enzymatic hydrolysis of whey proteins[J].International Dairy Journal,2006,16(11):1315-1323.  
[50] ZHOU J H,MA L L,XU H H,et al.Immunomodulating effects of casein-derived peptides QEPVL and QEPV on lymphocytes in vitro and in vivo[J].Food & Function,2014,5(9):2061-2069.