[1] HEO J M,OPAPEJU F O,PLUSKE J R,et al.Gastrointestinal health and function in weaned pigs:a review of feeding strategies to control post-weaning diarrhoea without using in-feed antimicrobial compounds[J].Journal of Animal Physiology and Animal Nutrition,2013,97(2):207-237.
[2] LALLēS J P,BOSI P,SMIDT H,et al.Weaning-a challenge to gut physiologists[J].Livestock Science,2007,108(1/2/3):82-93.
[3] 杨怀兵,李辉,黄建国,等.高锌在断奶仔猪日粮中的应用效果研究概述[J].中国畜牧兽医,2013,40(12):220-223.
[4] LI X L,YIN J D,LI D F,et al.Dietary supplementation with zinc oxide increases
IGF-Ⅰ and
IGF-Ⅰ receptor gene expression in the small intestine of weanling piglets[J].The Journal of Nutrition,2006,136(7):1786-1791.
[5] OU D Y,LI D F,CAO Y H,et al.Dietary supplementation with zinc oxide decreases expression of the stem cell factor in the small intestine of weanling pigs[J].The Journal of Nutritional Biochemistry,2007,18(12):820-826.
[6] ZHANG B K,GUO Y M.Supplemental zinc reduced intestinal permeability by enhancing occludin and zonula occludens protein-1 (
ZO-1) expression in weaning piglets[J].British Journal of Nutrition,2009,102(5):687-693.
[7] 胡彩虹,钱仲仓,刘海萍,等.高锌对早期断奶仔猪肠黏膜屏障和肠上皮细胞紧密连接蛋白表达的影响[J].畜牧兽医学报,2009,40(11):1638-1644.
[8] HU C H,XIAO K,SONG J,et al.Effects of zinc oxide supported on zeolite on growth performance,intestinal microflora and permeability,and cytokines expression of weaned pigs[J].Animal Feed Science and Technology,2013,181(1/2/3/4):65-71.
[9] VERSTEGEN M W A,WILLIAMS B A.Alternatives to the use of antibiotics as growth promoters for monogastric animals[J].Animal Biotechnology,2002,13(1):113-127.
[10] 王超.包膜氧化锌促仔猪生长效果及机理研究[D].博士学位论文.杭州:浙江大学,2013:13-16.
[11] CARLSON M S,HILL G M,LINK J E.Early- and traditionally weaned nursery pigs benefit from phase-feeding pharmacological concentrations of zinc oxide:effect on metallothionein and mineral concentrations[J].Journal of Animal Science,1999,77(5):1199-1207.
[12] 刘婷婷,张帅,邓斐月,等.谷氨酰胺与丁酸梭菌对断奶仔猪生长性能、免疫功能、小肠形态和肠道菌群的影响[J].动物营养学报,2011,23(6):998-1005.
[13] YANG C M,CAO G T,FERKET P R,et al.Effects of probiotic,
Clostridium butyricum,on growth performance,immune function,and cecal microflora in broiler chickens[J].Poultry Science,2012,91(9):2121-2129.
[14] LING Z X,LIU X,CHENG Y W,et al.
Clostridium butyricum combined with
Bifidobacterium infantis probiotic mixture restores fecal microbiota and attenuates systemic Inflammation in mice with antibiotic-associated diarrhea[J].BioMed Research International,2015,2015:582048.
[15] HU C H,XIAO K,LUAN Z S,et al.Early weaning increases intestinal permeability,alters expression of cytokine and tight junction proteins,and activates mitogen-activated protein kinases in pigs[J].Journal of Animal Science,2013,91(3):1094-1101.
[16] HU C H,GU L Y,LUAN Z S,et al.Effects of montmorillonite-zinc oxide hybrid on performance,diarrhea,intestinal permeability and morphology of weanling pigs[J].Animal Feed Science and Technology,2012,177(1/2):108-115.
[17] 胡彩虹,游兆彤,朱康,等.纳米氧化锌对断奶仔猪生长性能和肠黏膜屏障的影响[J].动物营养学报,2012,24(2):285-290.
[18] 计峰,罗绪刚,李素芬,等.高锌对断乳仔猪促生长作用及其机理的研究进展[J].动物营养学报,2003,15(3):1-5.
[19] 顾宪红,张宏福,佘锐萍,等.断奶日龄对消化器官形态及小肠组织化学的影响[J].家畜生态,2003,24(1):24-30.
[20] CARLSON M S,HOOVER S L,HILL G M,et al.Effect of pharmacological zinc on intestinal metallothionein concentration and morphology in the nursery pig[J].Journal of Animal Science,1998,76(Suppl.1):57.
[21] 申俊华,周安国,王之盛,等.包被氧化锌对断奶仔猪腹泻指数及肠道发育的影响[J].畜牧兽医学报,2013,44(6):894-900.
[22] DEPLANCKE B,GASKINS H R.Microbial modulation of innate defense:goblet cells and the intestinal mucus layer[J].The American Journal of Clinical Nutrition,2001,73(6):1131S-1141S.
[23] 隋欣.益生菌对雏鸡肠道杯状细胞数量及黏蛋白2含量的影响[D].硕士学位论文.哈尔滨:东北农业大学,2014:45-46
[24] LIU P,PIEPER R,RIEGER J,et al.Effect of dietary zinc oxide on morphological characteristics,mucin composition and gene expression in the colon of weaned piglets[J].PLoS One,2014,9(3):e91091.
[25] PEACE R M,CAMPBELL J,POLO J,et al.Spray-dried porcine plasma influences intestinal barrier function,inflammation,and diarrhea in weaned pigs[J].The Journal of Nutrition,2011,141(7):1312-1317.
[26] KIM J C,HANSEN C F,MULLAN B P,et al.Nutrition and pathology of weaner pigs:nutritional strategies to support barrier function in the gastrointestinal tract[J].Animal Feed Science and Technology,2012,173(1/2):3-16.
[27] SMITH F,CLARK J E,OVERMAN B L,et al.Early weaning stress impairs development of mucosal barrier function in the porcine intestine[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2010,298(3):G352-G363.
[28] ZHAO Y,QIN G X,SUN Z W,et al.Effects of soybean agglutinin on intestinal barrier permeability and tight junction protein expression in weaned piglets[J].International Journal of Molecular Sciences,2011,12(12):8502-8512.
[29] BERKES J,VISWANATHAN V K,SAVKOVIC S D,et al.Intestinal epithelial responses to enteric pathogens:effects on the tight junction barrier,ion transport,and inflammation[J].Gut,2003,52(3):439-451.
[30] WEILER F,MARBE T,SCHEPPACH W,et al.Influence of protein kinase C on transcription of the tight junction elements ZO-1 and occludin[J].Journal of Cellular Physiology,2005,204(1):83-86.
[31] 宦海琳,白建勇,周维仁,等.抗菌肽对仔猪血清生化指标、肠黏膜形态结构及空肠上皮紧密连接蛋白基因相对表达量的影响[J].动物营养学报,2015,27(12):3797-3804.
