REVIEW

Roles of Epidermal Growth Factor on Absorption of Inorganic Ions and other Nutrients in Animal Intestine

  • TANG Xiaopeng ,
  • LIU Hu ,
  • YANG Shufen ,
  • FANG Rejun
Expand
  • 1. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China;
    2. Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China

Received date: 2016-03-09

  Online published: 2016-08-17

Abstract

Epidermal growth factor (EGF) is one of the members of growth factor family, which can promote cell growth, cell migration, cell proliferation, wound healing, bone healing and nutrient transport and so on. EGF is known to positively influence intestinal nutrient transport processes, such as sodium, chloride, magnesium, inorganic phosphate, glucose, glutamine, peptides and serotonin. This review was mainly to outline the effects of EGF on nutrients transport, and to provide a better understanding of the utilization of EGF in animal production.

Cite this article

TANG Xiaopeng , LIU Hu , YANG Shufen , FANG Rejun . Roles of Epidermal Growth Factor on Absorption of Inorganic Ions and other Nutrients in Animal Intestine[J]. Chinese Journal of Animal Nutrition, 2016 , 28(8) : 2317 -2323 . DOI: 10.3969/j.issn.1006-267x.2016.08.001

References

[1] COHEN S.Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal[J].The Journal of Biological Chemistry,1962,237:1555-1562.
[2] ZENG F H,HARRIS R C.Epidermal growth factor,from gene organization to bedside[J].Seminars in Cell & Developmental Biology,2014,28:2-11.
[3] ALEXANDER P B,YUAN L F,YANG P Y,et al.EGF promotes mammalian cell growth by suppressing cellular senescence[J].Cell Research,2015,25(1):135-138.  
[4] IWABU A,SMITH K,ALLEN F D,et al.Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C δ-dependent pathway[J].The Journal of Biological Chemistry,2004,279(15):14551-14560.  
[5] JEONG W,KIM J,BAZER F W,et al.Epidermal growth factor stimulates proliferation and migration of porcine trophectoderm cells through protooncogenic protein kinase 1 and extracellular-signal-regulated kinases 1/2 mitogen-activated protein kinase signal transduction cascades during early pregnancy[J].Molecular and Cellular Endocrinology,2013,381(1/2):302-311.
[6] BEDFORD A,CHEN T,HUYNH E,et al.Epidermal growth factor containing culture supernatant enhances intestine development of early-weaned pigs in vivo:potential mechanisms[J].Journal of Biotechnology,2015,196/197:9-19.
[7] HUYNH E,LI J L.Generation of Lactococcus lactis capable of coexpressing epidermal growth factor and trefoil factor to enhance in vitro wound healing[J].Applied Microbiology and Biotechnology,2015,99(11):4667-4677.  
[8] MARQUEZ L,DE ABREU F A,FERREIRA C L,et al.Enhanced bone healing of rat tooth sockets after administration of epidermal growth factor (EGF) carried by liposome[J].Injury,2013,44(4):558-564.  
[9] YANG C B,ALBIN D M,WANG Z R,et al.Apical Na+-D-glucose cotransporter 1(SGLT1) activity and protein abundance are expressed along the jejunal crypt-villus axis in the neonatal pig[J].American Journal of Physiology Gastrointestinal and Liver Physiology,2010,300(1):G60-G70.
[10] CAO L S,OWSIANIK G,BECQ F,et al.Chronic exposure to EGF affects trafficking and function of ENaC channel in cystic fibrosis cells[J].Biochemical and Biophysical Research Communications,2005,331(2):503-511.  
[11] WANG C W,CHANG W L,HUANG Y C,et al.An essential role of cAMP response element-binding protein in epidermal growth factor-mediated induction of sodium/glucose cotransporter 1 gene expression and intestinal glucose uptake[J].The International Journal of Biochemistry & Cell Biology,2015,64:239-251.
[12] TRAPANI V,ARDUINI D,LUONGO F,et al.EGF stimulates Mg2+ influx in mammary epithelial cells[J].Biochemical and Biophysical Research Communications,2014,454(4):572-575.  
[13] XU H,COLLINS J F,BAI L Q,et al.Regulation of the human sodium-phosphate cotransporter NaPi-Ⅱb gene promoter by epidermal growth factor[J].American Journal of Physiology Cell Physiology,2001,280(3):C628-C636.
[14] XU H,INOUYE M,HINES E R,et al.Transcriptional regulation of the human NaPi-Ⅱb cotransporter by EGF in Caco-2 cells involves c-myb[J].American Journal of Physiology Cell Physiology,2003,284(5):C1262-C1271.
[15] RAY E C,AVISSAR N E,SALLOUM R,et al.Growth hormone and epidermal growth factor upregulate specific sodium-dependent glutamine uptake systems in human intestinal C2BBe1 cells[J].The Journal of Nutrition,2005,135(1):14-18.
[16] PAVLOV T S,LEVCHENKO V,STARUSCHENKO A.Role of Rho GDP dissociation inhibitor α in control of epithelial sodium channel (ENaC)-mediated sodium reabsorption[J].Journal of Biological Chemistry,2014,289(41):28651-28659.  
[17] O'MAHONY F,TOUMI F,MROZ M S,et al.Induction of Na+/K+/2Cl- cotransporter expression mediates chronic potentiation of intestinal epithelial Cl- secretion by EGF[J].American Journal of Physiology Cell Physiology,2008,294(6):C1362-C1370.
[18] MROZ M S,KEELY S J.Epidermal growth factor chronically upregulates Ca2+-dependent Cl- conductance and TMEM16A expression in intestinal epithelial cells[J].The Journal of Physiology,2012,590(8):1907-1920.  
[19] TRINH N T N,PRIVÉ A,MAILLÉ E,et al.EGF and K+ channel activity control normal and cystic fibrosis bronchial epithelia repair[J].American Journal of Physiology Lung Cellular Molecular Physiology,2008,295(5):L866-L880.
[20] BEZZERIDES V J,RAMSEY I S,KOTECHA S,et al.Rapid vesicular translocation and insertion of TRP channels[J].Nature Cell Biology,2004,6(8):709-720.  
[21] XU H,ZHANG B,LI J,et al.Epidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription[J].American Journal of Physiology Cell Physiology,2010,299(1):C51-C57.
[22] ZHELEZNOVA N N,WILSON P D,STARUSCHENKO A.Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells[J].Biochimca et Biophysica Acta (BBA):Molecular Basis of Disease,2011,1812(10):1301-1313.  
[23] STARUSCHENKO A,PALYGIN O,ILATOVSKAYA D V,et al.Epidermal growth factors in the kidney and relationship to hypertension[J].American Journal of Physiology Renal Physiology,2013,305(1):F12-F20.
[24] MALAKOOTI J,SAKSENA S,GILL R K,et al.Transcriptional regulation of the intestinal luminal Na+ and Cl- transporters[J].Biochemical Journal,2011,435(2):313-325.  
[25] XU H,COLLINS J F,BAI L Q,et al.Epidermal growth factor regulation of rat NHE2 gene expression[J].American Journal of Physiology Cell Physiology,2001,281(2):C504-C513.
[26] AMIN M R,ORENUGA T,TYAGI S,et al.Tumor necrosis factor-α represses the expression of NHE2 through NF-κB activation in intestinal epithelial cell model,C2BBe1[J].Inflammatory Bowel Diseases,2011,17(3):720-731.  
[27] SPENCER A G,LABONTE E D,ROSENBAUM D P,et al.Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in rats and inhibits Na+ uptake in humans[J].Science Translational Medicine,2014,6(227):227-236.
[28] XU H,CHEN R J,GHISHAN F K.Subcloning,localization,and expression of the rat intestinal sodium-hydrogen exchanger isoform 8[J].American Journal of Physiology Gastrointestinal Liver Physiology,2005,289(1):G36-G41.
[29] KEELY S J,MONTROSE M H,BARRETT K E.Electrolyte secretion and absorption:small intestine and colon[M]//YAMADA T.Textbook of Gastroenterology.5th ed.London:Blackwell Publishing Ltd,2009,330-367.
[30] FRIZZELL R A,HANRAHAN J W.Physiology of epithelial chloride and fluid secretion[J].Cold Spring Harbor Perspectives in Medicine,2012,2(6):a009563.
[31] CARLOS M A,NWAGWU C,AO M,et al.Epidermal growth factor stimulates chloride transport in primary cultures of weanling and adult rabbit colonocytes[J].Journal of Pediatric Gastroenterology and Nutrition,2007,44(3):300-311.  
[32] YANG Y D,CHO H,KOO J Y,et al.TMEM16A confers receptor-activated calcium-dependent chloride conductance[J].Nature,2008,455(7217):1210-1215.  
[33] DE BAAIJ J H F,HOENDEROP J G L,BINDELS R J M.Regulation of magnesium balance:lessons learned from human genetic disease[J].Clinical Kidney Journal,2012,5(Suppl.1):i15-i24.
[34] MUALLEM S,MOE O W.When EGF is offside,magnesium is wasted[J].Journal of Clinical Investigation,2007,117(8):2086-2089.  
[35] LEDEGANCK K J,BOULET G A,HORVATH C A,et al.Expression of renal distal tubule transporters TRPM6 and NCC in a rat model of cyclosporine nephrotoxicity and effect of EGF treatment[J].American Journal of Physiology Renal Physiology,2011,301(3):F486-F493.
[36] LEDEGANCK K J,BOULET G A,BOGERS J J,et al.The TRPM6/EGF pathway is downregulated in a rat model of cisplatin nephrotoxicity[J].PLoS One,2013,8(2):e57016.
[37] FANG R J,XIANG Z F,CAO M H,et al.Different phosphate transport in the duodenum and jejunum of chicken response to dietary phosphate adaptation[J].Asian-Australasian Journal of Animal Sciences,2012,25(10):1457-1465.  
[38] WAGNER C A,HERNANDO N,FORSTER I C,et al.The SLC34 family of sodium-dependent phosphate transporters[J].Pflügers Archiv:European Journal of Physiology,2014,466(1):139-153.
[39] FENOLLAR-FERRER C,PATTI M,KNÖPFEL T,et al.Structural fold and binding sites of the human Na+-phosphate cotransporter NaPi-Ⅱ[J].Biophysical Journal,2014,106(6):1268-1279.  
[40] HUANG Q,LI N,ZHU W M,et al.Glutamine transporter ASCT2 was down-regulated in ischemic injured human intestinal epithelial cells and reversed by epidermal growth factor[J].Journal of Parenteral & Enteral Nutrition,2007,31(2):86-93.  
[41] POCHINI L,SCALISE M,GALLUCCIO M,et al.Membrane transporters for the special amino acid glutamine:structure/function relationships and relevance to human health[J].Frontiers in Chemistry,2014,2:61.
[42] CONSOLE L,SCALISE M,TARMAKOVA Z,et al.N-linked glycosylation of human SLC1A5(ASCT2) transporter is critical for trafficking to membrane[J].Biochimica et Biophysica Acta (BBA):Molecular Cell Research,2015,1853(7):1636-1645.  
[43] AVISSAR N E,SAX H C,TOIA L.In human entrocytes,GLN transport and ASCT2 surface expression induced by short-term EGF are MAPK,PI3K,and rho-dependent[J].Digestive Diseases and Sciences,2008,53(8):2113-2125.  
[44] NIELSEN C U,AMSTRUP J,STEFFANSEN B,et al.Epidermal growth factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line[J].American Journal of Physiology Gastrointestinal and Liver Physiology,2001,281(1):G191-G199.
[45] NIELSEN C U,AMSTRUP J,NIELSEN R,et al.Epidermal growth factor and insulin short-term increase hPepT1-mediated glycylsarcosine uptake in Caco-2 cells[J].Acta Physiologica Scandinavica,2003,178(2):139-148.  
[46] XU S,WANG D,ZHANG P,et al.Oral administration of Lactococcus lactis-expressed recombinant porcine epidermal growth factor stimulates the development and promotes the health of small intestines in early-weaned piglets[J].Journal of Applied Microbiology,2015,119(1):225-235.  
[47] CHAUDHRY R M,SCOW J S,MADHAVAN S,et al.Acute enterocyte adaptation to luminal glucose:a posttranslational mechanism for rapid apical recruitment of the transporter GLUT2[J].Journal of Gastrointestinal Surgery,2012,16(2):312-319.  
[48] ZHENG Y,SCOW J S,DUENES J A,et al.Mechanisms of glucose uptake in intestinal cell lines:role of GLUT2[J].Surgery,2012,151(1):13-25.  
[49] KELLETT G L,BROT-LAROCHE E,MACE O J,et al.Sugar absorption in the intestine:the role of GLUT2[J].Annual Review of Nutrition,2008,28(1):35-54.  
[50] SONG X Z,XU J Q,WANG T,et al.Traditional Chinese medicine decoction enhances growth performance and intestinal glucose absorption in heat stressed pigs by up-regulating the expressions of SGLT1 and GLUT2 mRNA[J].Livestock Science,2010,128(1/2/3),75-81.
[51] HUANG C Y,HSIAO J K,LU Y Z,et al.Anti-apoptotic PI3K/Akt signaling by sodium/glucose transporter 1 reduces epithelial barrier damage and bacterial translocation in intestinal ischemia[J].Laboratory Investigation,2011,91(2):294-309.  
[52] CELLINI C,XU J,BUCHMILLER-CRAIR T.Effect of epidermal growth factor on small intestinal sodium/glucose cotransporter-1 expression in a rabbit model of intrauterine growth retardation[J].Journal of Pediatric Surgery,2005,40(12):1892-1897.  
[53] CUI X F,ZHOU W M,YANG Y,et al.Epidermal growth factor upregulates serotonin transporter and its association with visceral hypersensitivity in irritable bowel syndrome[J].World Journal of Gastroenterology,2014,20(37):13521-13529.  
[54] ESMAILI A,NAZIR S F,BORTHAKUR A,et al.Enteropathogenic Escherichia coli infection inhibits intestinal serotonin transporter function and expression[J].Gastroenterology,2009,137(6):2074-2083.  
[55] NAZIR S,KUMAR A,CHATTERJEE I,et al.Mechanisms of intestinal serotonin transporter (SERT) upregulation by TGF-β1 induced non-smad pathways[J].PLoS One,2015,10(5):e0120447.
[56] GILL R K,ANBAZHAGAN A N,ESMAILI A,et al.Epidermal growth factor upregulates serotonin transporter in human intestinal epithelial cells via transcriptional mechanisms[J].American Journal of Physiology Gastrointestinal and Liver Physiology,2011,300(4):G627-G636.
Outlines

/