REVIEW

Regulation Mechanism of Adiponectin and Its Receptors on Lipid Metabolism Signal Transduction Pathways

  • MENG Bo ,
  • FAN Ruiming ,
  • LUAN Xinhong
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  • College of Veterinary and Animal Science, Shenyang Agricultural University, Shenyang 110866, China

Received date: 2016-05-12

  Online published: 2016-10-17

Abstract

Adiponectin (AdipoQ) is one of cytokines secreted by adipose tissue, which plays an important role in regulating lipid metabolism of livestock and poultry. AdipoQ regulates adenosine 5'-monophosphate-activated protein kinase α (AMPKα), p38 mitogen-activated protein kinase (p38MARK) and peroxisome proliferator activated receplor-α (PPARα)to participate their signal transduction pathways mainly through binding adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2), which is associated with regulating lipid metabolism. At present, there has been some progress in the research on the lipid metabolism signaling transduction pathways mediated by AdipoQ. In this paper, the structures of AdipoQ and its receptors, as well as the regulation mechanism of lipid metabolism mediated by AdipoQ and its receptors were reviewed.

Cite this article

MENG Bo , FAN Ruiming , LUAN Xinhong . Regulation Mechanism of Adiponectin and Its Receptors on Lipid Metabolism Signal Transduction Pathways[J]. Chinese Journal of Animal Nutrition, 2016 , 28(10) : 3059 -3063 . DOI: 10.3969/j.issn.1006-267x.2016.10.006

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