REVIEW

Regulation and Mechanism of Wnt/β-Catenin on the Development of Uterus in Mammals

  • YANG Lijie ,
  • YANG Weiren ,
  • HUANG Libo ,
  • FENG Qiang ,
  • JIANG Shuzhen ,
  • YANG Zaibin
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  • 1. College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China;
    2. Tai'an Central Hospital, Tai'an 271000, China

Received date: 2016-03-28

  Online published: 2016-10-17

Abstract

The orderly operation of the physiological activity program within the body depends on the coordination among different signal transduction pathways. Wnt (name derived from the Drosophila gene Wingless and mouse oncogene int-1) signaling pathway has received extensive attention of scholars and became a research hotspots in the fields of molecular biology and cell biology. In this paper, regulation and mechanism of Wnt/β-catenin signaling pathway on development of uterus in mammals were studied. The paper reviewed the regulating mechanism of glycogen synthase kinase 3β (GSK-3β), adenomatous polyposis coli (APC), scaffold protein (Axin) and osteoblast inhibitory factor (Dkk) on Wnt/β-catenin signaling pathway and intranuclear activated of Wnt/β-catenin signaling pathway, to further revealed the regulating mechanism in the uterus, and provided reference for the treatment of uterine diseases.

Cite this article

YANG Lijie , YANG Weiren , HUANG Libo , FENG Qiang , JIANG Shuzhen , YANG Zaibin . Regulation and Mechanism of Wnt/β-Catenin on the Development of Uterus in Mammals[J]. Chinese Journal of Animal Nutrition, 2016 , 28(10) : 3070 -3075 . DOI: 10.3969/j.issn.1006-267x.2016.10.008

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