A New Hypothesis for the Mechanism of Metabolic Saving of Amino Acids of Pigs

SUN Zhihong; LI Mao; XU Qingqing; YIN Yulong; ZHU Weiyun; JIANG Qingyan; HUANG Feiruo

doi:10.3969/j.issn.1006-267x.2016.11.001

Chinese Journal of Animal Nutrition >

2016 , Vol. 28 >Issue 11: 3369 - 3376

DOI: https://doi.org/10.3969/j.issn.1006-267x.2016.11.001

REVIEW

A New Hypothesis for the Mechanism of Metabolic Saving of Amino Acids of Pigs

SUN Zhihong ,
LI Mao ,
XU Qingqing ,
YIN Yulong ,
ZHU Weiyun ,
JIANG Qingyan ,
HUANG Feiruo

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1. Laboratory for Bio-Feed and Animal Nutrition, Southwest University, Chongqing 400715, China;
2. Institute of Subtropical Agriculture, the Chinese Academy of Sciences, Changsha 410125, China;
3. College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China;
4. College of Animal Science and Technology, Huanan Agricultural University, Guangzhou 510642, China;
5. College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China

Received date: 2016-04-11

Online published: 2016-11-18

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Abstract

Urinary nitrogen excretion accounts for 60% to 70% of the total nitrogen excretion of pigs. The production rate of urea, which is the main nitrogen-containing substance in the urine, to a large extent determines the urinary nitrogen and total nitrogen excretion. Therefore, declining the production rate of urea in liver of pigs is a fundamental approach for reducing total nitrogen excretion. This review summarized the existing nutrition regulatory measures for reducing nitrogen excretion in pigs, characterized the nitrogen direct precursors (ammonia) and indirect precursors (glycine and alanine) of urea synthesis in liver, and the mechanism of metabolic fuel function substitution of amino acid (AA). On this basis, a new hypothesis for the regulatory mechanism of metabolic saving of AA was proposed, the essence of which is to promote the efficiency of substances like as pyruvate/glucose being as metabolic fuel, decline metabolic rate of AA especially of glutamate, decrease the net flow of nitrogen precursors for urea synthesis in portal vein, urea synthesis in liver and urinary nitrogen excretion.

Key words： nitrogen excretion; amino acids; metabolic saving; pyruvate dehydrogenase

Cite this article

SUN Zhihong , LI Mao , XU Qingqing , YIN Yulong , ZHU Weiyun , JIANG Qingyan , HUANG Feiruo . A New Hypothesis for the Mechanism of Metabolic Saving of Amino Acids of Pigs[J]. Chinese Journal of Animal Nutrition, 2016 , 28(11) : 3369 -3376 . DOI: 10.3969/j.issn.1006-267x.2016.11.001

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