Effects of Zinc Oxide Nanoparticles on Growth Performance, Serum Immune and Biochemical Indices of Weaned Piglets

WANG Bin; LIU Lujie; ZHU Jia; ZOU Junbiao; LENG Dongbi; WANG Minqi

doi:10.3969/j.issn.1006-267x.2016.11.032

Chinese Journal of Animal Nutrition >

2016 , Vol. 28 >Issue 11: 3626 - 3633

DOI: https://doi.org/10.3969/j.issn.1006-267x.2016.11.032

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Effects of Zinc Oxide Nanoparticles on Growth Performance, Serum Immune and Biochemical Indices of Weaned Piglets

WANG Bin ,
LIU Lujie ,
ZHU Jia ,
ZOU Junbiao ,
LENG Dongbi ,
WANG Minqi

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1. College of Animal Science, Zhejiang University, Hangzhou 310058, China;
2. Jiangxi Innovating Science & Technology Co., Ltd., Nanchang 330115, China

Received date: 2016-05-26

Online published: 2016-11-18

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Abstract

This study was conducted to investigate the effects of different doses of dietary zinc oxide nanoparticles on growth performance, serum immune and biochemical indices of weaned piglets. A total of 150 28-day-old weaned piglets (Duroc×Landrace×Yorkshire) with an initial average body weight of (9.37±0.48) kg were randomly assigned into 5 groups with 3 replicates per group and 10 piglets per replicate. The piglets in the control group were fed a basal diet, in high zinc oxide group were fed the basal diet supplemented with 3 000 mg/kg common zinc oxide, and in three trial groups (group 1, 2 and 3) were fed the basal diet supplemented with 150, 300 and 450 mg/kg zinc oxide nanoparticles, respectively. The experiment lasted for 21 days. The results showed as follows:1) compared with the control group, dietary supplementation of zinc oxide nanoparticles significantly increased the average daily feed intake and average daily gain (P<0.05), significantly decreased the ratio of feed to gain and diarrhea rate (P<0.05) of pigs, and the optimal supplemental levels of zinc oxide nanoparticles were 300 and 450 mg/kg which had the similar effects with common zinc oxide. 2) Compared with the control group, dietary zinc oxide nanoparticles and common zinc oxide significantly increased the contents of serum immunoglobulin A, interleukin-6 and tumor necrosis factor-α (P<0.05), and significantly reduced serum urea nitrogen content (P<0.05). These results suggest that dietary supplementation of 300 or 450 mg/kg zinc oxide nanoparticles has beneficial effects on immunity of weaned piglets, which also can increase their growth performance and decrease diarrhea rate. Accordingly, the new zinc oxide nanoparticles have a potential to substitute common zinc oxide.

Key words： zinc oxide nanoparticles; weaned piglets; growth performance; cytokines; immune indices; serum biochemical indices

Cite this article

WANG Bin , LIU Lujie , ZHU Jia , ZOU Junbiao , LENG Dongbi , WANG Minqi . Effects of Zinc Oxide Nanoparticles on Growth Performance, Serum Immune and Biochemical Indices of Weaned Piglets[J]. Chinese Journal of Animal Nutrition, 2016 , 28(11) : 3626 -3633 . DOI: 10.3969/j.issn.1006-267x.2016.11.032

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