Molecular Nutrition

Inhibitory Effects of Antimicrobial Peptides on Lipopolysaccharide-Induced Inflammation

  • YANG Yanyi ,
  • CHEN Yun ,
  • GAO Shuang ,
  • LIU Qi ,
  • CHEN Chong ,
  • YAO Shuhua ,
  • DENG Junliang
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  • Key Laboratory of Animal Disease & Human Health of Sichuan Province, Key Laboratory of Environmental Hazard and Animal Disease of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China

Received date: 2016-06-21

  Online published: 2016-12-17

Abstract

Antimicrobial peptides (AMPs) are a kind of small molecular polypeptide which show the specific antibacterial mechanism to multiple drug-resistant strains. In addition, with anti-inflammatory activity, AMPs relieve inflammation by directly neutralizing lipopolysaccharide (LPS) and inhibiting the release of biological inflammatory factors. Meanwhile, they also affect the acquired immunity through the chemotaxis of leukocytes and promoting the proliferation of the immune cells to adjust the host immune system and play a protective role. This essay summarized the mechanism of LPS induced inflammation and the AMPs to inhibit LPS induced inflammation in recent years.

Cite this article

YANG Yanyi , CHEN Yun , GAO Shuang , LIU Qi , CHEN Chong , YAO Shuhua , DENG Junliang . Inhibitory Effects of Antimicrobial Peptides on Lipopolysaccharide-Induced Inflammation[J]. Chinese Journal of Animal Nutrition, 2016 , 28(12) : 3770 -3776 . DOI: 10.3969/j.issn.1006-267x.2016.12.008

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