ZHANG Huan, WANG Jiaqi, GAO Yanan, ZHENG Nan . Research Progress of Mycotoxins on DNA Damage of Different Cells[J]. Chinese Journal of Animal Nutrition, 2017 , 29(2) : 403 -409 . DOI: 10.3969/j.issn.1006-267x.2017.02.006

[1] LI S J,EDIAGE E N,DE SAEGER S,et al.Occurrence and pathology of mycotoxins in commercial parrot feeds[J].World Mycotoxin Journal,2013,6(4):449-453.  

[2] PINTON P,NOUGAYRÈDE J P,RIO J C D,et al.The food contaminant deoxynivalenol,decreases intestinal barrier permeability and reduces claudin expression[J].Toxicology and Applied Pharmacology,2009,237(1):41-48.  

[3] AKBARI P,BRABER S,GREMMELS H,et al.Deoxynivalenol:a trigger for intestinal integrity breakdown[J].The FASEB Journal,2014,28(6):2414-2429.  

[4] MAHFOUD R,MARESCA M,GARMY N,et al.The mycotoxin patulin alters the barrier function of the intestinal epithelium:mechanism of action of the toxin and protective effects of glutathione[J].Toxicology and Applied Pharmacology,2002,181(3):209-218.  

[5] DENLI M,BLANDON J C,GUYNOT M E,et al.Efficacy of a new ochratoxin-binding agent (OcraTox) to counteract the deleterious effects of ochratoxin A in laying hens[J].Poultry Science,2008,87(11):2266-2272.  

[6] PESTKA J J,SMOLINSKI A T.Deoxynivalenol:toxicology and potential effects on humans[J].Journal of Toxicology and Environmental Health,2005,8(1):39-69.  

[7] SHIER W T,SHIER A C,XIE W,et al.Structure-activity relationships for human estrogenic activity in zearalenone mycotoxins[J].Toxicon,2001,39(9):1435-1448.  

[8] OBREMSKI K,GONKOWSKI S,WOJTACHA P.Zearalenone-induced changes in the lymphoid tissue and mucosal nerve fibers in the porcine ileum[J].Polish Journal of Veterinary Sciences,2015,18(2):357-365.

[9] MARRIOTT I,MASON M J,ELHOFY A,et al.Substance P activates NF-κB independent of elevations in intracellular calcium in murine macrophages and dendritic cells[J].Journal of Neuroimmunology,2000,102(2):163-171.  

[10] 高亚男,王加启,李松励,等.霉菌毒素影响肠道黏膜屏障功能[J].动物营养学报,2016,28(3):674-679.

[11] GOOSSENS J,PASMANS F,VERBRUGGHE E,et al.Porcine intestinal epithelial barrier disruption by the Fusariummycotoxins deoxynivalenol and T-2 toxin promotes transepithelial passage of doxycycline and paromomycin[J].BMC Veterinary Research,2012,8(1):245.

[12] CALONI F,STAMMATI A,FRIGGÈ G,et al.Aflatoxin M1 absorption and cytotoxicity on human intestinal in vitro model[J].Toxicon,2006,47(4):409-415.  

[13] DIESING A K,NOSSOL C,PANTHER P,et al.Mycotoxin deoxynivalenol (DON) mediates biphasic cellular response in intestinal porcine epithelial cell lines IPEC-1 and IPEC-J2[J].Toxicology Letters,2011,200(1/2):8-18.

[14] PINTON P,TSYBULSKYY D,LUCIOLI J,et al.Toxicity of deoxynivalenol and its acetylated derivatives on the intestine:differential effects on morphology,barrier function,tight junction proteins,and mitogen-activated protein kinases[J].Toxicological Sciences,2012,130(1):180-190.  

[15] BONY S,CARCELEN M,OLIVIER L,et al.Genotoxicity assessment of deoxynivalenol in the Caco-2 cell line model using the Comet assay[J].Toxicology Letters,2006,166(1):67-76.  

[16] TARANU I,BRAICU C,MARIN D E,et al.Exposure to zearalenone mycotoxin alters in vitro porcine intestinal epithelial cells by differential gene expression[J].Toxicology Letters,2015,232(1):310-325.  

[17] ABID-ESSEFI S,BAUDRIMONT I,HASSEN W,et al.DNA fragmentation,apoptosis and cell cycle arrest induced by zearalenone in cultured DOK,Vero and Caco-2 cells:prevention by Vitamin E[J].Toxicology,2003,192(2/3):237-248.

[18] PACHECO G D,SILVA C A D,PINTON P,et al.Phytic acid protects porcine intestinal epithelial cells from deoxynivalenol (DON) cytotoxicity[J].Experimental and Toxicologic Pathology,2012,64(4):345-347.  

[19] KOUADIO J H,DANO S D,MOUKHA S,et al.Effects of combinations of Fusarium mycotoxins on the inhibition of macromolecular synthesis,malondialdehyde levels,DNA methylation and fragmentation,and viability in Caco-2 cells[J].Toxicon,2007,49(3):306-317.  

[20] KANG C,LEE H,YOO Y S,et al.Evaluation of oxidative DNA damage using an alkaline single cell gel electrophoresis (SCGE) comet assay,and the protective effects of N-acetylcysteine amide on zearalenone-induced cytotoxicity in Chang liver cells[J].Toxicological Research,2013,29(1):43-52.  

[21] GAZZAH A C,CAMOIN L,ABID S,et al.Identification of proteins related to early changes observed in Human hepatocellular carcinoma cells after treatment with the mycotoxin Zearalenone[J].Experimental and Toxicologic Pathology,2013,65(6):809-816.  

[22] SAHU S C,O'DONNELL M W,Jr,WIESENFELD P L.Comparative hepatotoxicity of deoxynivalenol in rat,mouse and human liver cells in culture[J].Journal of Applied Toxicology,2010,30(6):566-573.  

[23] RUMORA L,DOMIJAN A M,GRUBIŠI? T ?,et al.Mycotoxin fumonisin B₁ alters cellular redox balance and signalling pathways in rat liver and kidney[J].Toxicology,2007,242(1/2/3):31-38.

[24] SAHU S C,GARTHOFF L H,ROBL M G,et al.Rat liver clone-9 cells in culture as a model for screening hepatotoxic potential of food-related products:hepatotoxicity of deoxynivalenol[J].Journal of Applied Toxicology,2008,28(6):765-772.  

[25] LE HÉGARAT L,DUMONT J,JOSSE R,et al.Assessment of the genotoxic potential of indirect chemical mutagens in HepaRG cells by the comet and the cytokinesis-block micronucleus assays[J].Mutagenesis,2010,25(6):555-560.  

[26] DOMIJAN A M,? ELJE? I? D,PERAICA M,et al.Early toxic effects of fumonisin B₁ in rat liver[J].Human & Experimental Toxicology,2008,27(12):895-900.  

[27] AYED-BOUSSEMA I,BOUAZIZ C,RJIBA K,et al.The mycotoxin Zearalenone induces apoptosis in human hepatocytes (HepG2) via p53-dependent mitochondrial signaling pathway[J].Toxicology in Vitro,2008,22(7):1671-1680.  

[28] TAKAKURA N,NESSLANY F,FESSARD V,et al.Absence of in vitro genotoxicity potential of the mycotoxin deoxynivalenol in bacteria and in human TK6 and HepaRG cell lines[J].Food and Chemical Toxicology,2014,66:113-121.

[29] DENLI M,BLANDON J C,GUYNOT M E,et al.Effects of dietary AflaDetox on performance,serum biochemistry,histopathological changes,and aflatoxin residues in broilers exposed to aflatoxin B1[J].Poultry Science,2009,88(7):1444-1451.  

[30] MILI? EVI? D,JURI? V,STEFANOVI? S,et al.Survey of slaughtered pigs for occurrence of ochratoxin A and porcine nephropathy in Serbia[J].International Journal of Molecular Sciences,2008,9(11):2169-2183.  

[31] RUIZ M J,MACÁKOVÁ P,JUAN-GARCÍA A,et al.Cytotoxic effects of mycotoxin combinations in mammalian kidney cells[J].Food and Chemical Toxicology,2011,49(10):2718-2724.  

[32] BOUAZIZ C,ABID-ESSEFI S,BOUSLIMI A,et al.Cytotoxicity and related effects of T-2 toxin on cultured Vero cells[J].Toxicon,2006,48(3):343-352.  

[33] ARBILLAGA L,AZQUETA A,EZPELETA O,et al.Oxidative DNA damage induced by ochratoxin A in the HK-2 human kidney cell line:evidence of the relationship with cytotoxicity[J].Mutagenesis,2006,22(1):35-42.  

[34] LEBRUN S,FÖLLMANN W.Detection of ochratoxin A-induced DNA damage in MDCK cells by alkaline single cell gel electrophoresis (comet assay)[J].Archives of Toxicology,2002,75(11/12):734-741.

[35] LIU B H,WU T S,YU F Y,et al.Mycotoxin patulin activates the p38 kinase and JNK signaling pathways in human embryonic kidney cells[J].Toxicological Sciences,2006,89(2):423-430.  

[36] CAVIN C,DELATOUR T,MARIN-KUAN M,et al.Ochratoxin A-mediated DNA and protein damage:roles of nitrosative and oxidative stresses[J].Toxicological Sciences,2009,110(1):84-94.  

[37] WEIDNER M,WELSCH T,HVBNER F,et al.Identification and apoptotic potential of T-2 toxin metabolites in human cells[J].Journal of Agricultural and Food Chemistry,2012,60(22):5676-5684.  

[38] CHANG C H,YU F Y,WU T S,et al.Mycotoxin citrinin induced cell cycle G2/M arrest and numerical chromosomal aberration associated with disruption of microtubule formation in human cells[J].Toxicological Sciences,2011,119(1):84-92.  

[39] WANGIKAR P,DWIVEDI P,SINHA N.Effect in rats of simultaneous prenatal exposure to ochratoxin A and aflatoxin B₁.Ⅰ.Maternal toxicity and fetal malformations[J].Birth Defects Research Part B:Developmental and Reproductive Toxicology,2004,71(6):343-351.  

[40] SAVA V,VELASQUEZ A,SONG S J,et al.Adult hippocampal neural stem/progenitor cells in vitro are vulnerable to the mycotoxin ochratoxin-A[J].Toxicological Sciences,2007,98(1):187-197.  

[41] SAVA V,REUNOVA O,VELASQUEZ A,et al.Acute neurotoxic effects of the fungal metabolite ochratoxin-A[J].Neurotoxicology,2006,27(1):82-92.  

[42] STOCKMANN-JUVALA H,NAARALA J,LOIKKANEN J,et al.Fumonisin B₁-induced apoptosis in neuroblastoma,glioblastoma and hypothalamic cell lines[J].Toxicology,2006,225(2/3):234-241.

[43] OSUCHOWSKI M F,SHARMA R P.Fumonisin B₁ induces necrotic cell death in BV-2 cells and murine cultured astrocytes and is antiproliferative in BV-2 cells while N2A cells and primary cortical neurons are resistant[J].Neurotoxicology,2005,26(6):981-992.  

[44] ISLAM Z,HEGG C C,BAE H K,et al.Satratoxin G-induced apoptosis in PC-12 neuronal cells is mediated by PKR and caspase independent[J].Toxicological Sciences,2008,105(1):142-152.