Molecular Nutrition

Effects of Myostatin Inhibitory Peptides Supplementation on Growth Performance, Body Composition, Serum Biochemical Indices, Serum and Liver Immune Indices of Sea Bass (Lateolabrax japonicas)

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  • Institute of Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China

Received date: 2016-07-26

  Online published: 2017-02-17

Abstract

The study was conducted to investigate the effects of myostatin (MSTN) inhibitory peptides supplementation on growth performance, body composition, serum biochemical indices, serum and liver immune indices of sea bass (Lateolabrax japonicas). Using juvenile sea bass with the average initial body weight of (9.05±0.05) g as test animals, after one week feeding, a total of 480 healthy sea bass with the similar size were randomly divided into 4 groups with 4 replicates (aquariums) per group and 30 fish per replicate. The fish in those 4 groups were fed experimental diets supplemented with 0 (control), 0.25%, 0.50% and 0.75% MSTN inhibitory peptides, respectively, and lasted for 135 days. The results showed as follows:1) the weight gain rate (WGR), specific growth rate (SGR) and survival rate (SR) of fish fed diet containing 0.50% MSTN inhibitory peptides were significantly higher than those of fish fed control diet (P<0.05), while the feed conversion ratio (FCR) of fish fed diets containing 0.25%, 0.50% and 0.75% MSTN inhibitory peptides was significantly lower than that of fish fed control diet (P<0.05), and 0.50% group had the lowest FCR. 2) No significant differences were found in the contents of whole body moisture, crude protein, crude lipid and ash among all groups (P>0.05), while dorsal muscle crude lipid content of fish fed diets containing 0.25%, 0.50% and 0.75% MSTN inhibitory peptides was significantly lower than that of fish fed control diet (P<0.05), and dorsal muscle crude protein content of fish fed diet containing 0.50% MSTN inhibitory peptides was significantly higher than that of fish fed control diet (P<0.05). 3) Serum total protein (TP), albumin (ALB) and total cholesterol (TC) contents of fish fed diet containing 0.25% MSTN inhibitory peptides were significantly lower than those of fish fed other diets (P<0.05). Yet, no significant difference was discovered in serum triglycerides (TG) content among all groups (P>0.05). 4) Serum alkaline phosphatase (ALP) activity of fish fed diets containing 0.50% and 0.75% MSTN inhibitory peptides were significantly higher than that of fish fed control diet (P<0.05). Liver lysozyme (LZM) activity of fish fed diets containing 0.25% and 0.50% MSTN inhibitory peptides was significantly higher than that of fish fed control diet (P<0.05). No significant differences were found in liver total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) activity among all groups (P>0.05). According to the above results, it is concluded that MSTN inhibitory peptides can effectively improve growth and immune capacity of sea bass. In addition, the suitable dietary MSTN inhibitory peptides supplemental level is 0.50% for sea bass under this experimental condition.

Cite this article

LI Yating, TIAN Mengli, XIE Huanhuan, GUO Tianyu, NIU Jin, LIU Yongjian, TIAN Lixia . Effects of Myostatin Inhibitory Peptides Supplementation on Growth Performance, Body Composition, Serum Biochemical Indices, Serum and Liver Immune Indices of Sea Bass (Lateolabrax japonicas)[J]. Chinese Journal of Animal Nutrition, 2017 , 29(2) : 519 -528 . DOI: 10.3969/j.issn.1006-267x.2017.02.019

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