This trial was carried out to evaluate the nutritional values of safflower meal and milk thistle meal for growing Rex rabbits by feeding and digestion experiments. Eighteen healthy white growing Rex rabbits at the age of 60 days with an average body weight of (1.73±0.21) kg were randomly divided into 3 groups with 6 replicates per group and 1 rabbit per replicate. The rabbits in the 3 groups were fed the basal diet, safflower meal diet (85% basal diet+15% safflower meal) and milk thistle meal diet (85% basal diet+15% milk thistle meal), respectively.Both pre-trial and formal trial periods lasted for 5 days. The gross energy (GE) and the contents of various of nutritious materials of safflower meal and milk thistle meal were measured by chemical analysis method. The apparent digestibility of above indices for growing Rex rabbits was measured by total feces collection method. The results showed as follows:the GE and the contents of dry matter (DM), crude protein (CP), crude fiber (CF), neutral detergent fiber (NDF), acid detergent fiber (ADF), acid detergent lignin (ADL), ether extract (EE), crude ash (Ash), calcium (Ca), phosphorus (P) and nitrogen free extract (NFE) of safflower meal were 18.81 MJ/kg, 93.76%, 23.94%, 14.95%, 19.92%, 11.99%, 2.19%, 1.64%, 4.93%, 0.37%, 0.57% and 49.32%, respectively; and those of milk thistle meal were 17.12 MJ/kg, 91.94%, 23.62%, 16.21%, 38.57%, 22.73%, 4.04%, 2.07%, 5.31%, 0.29%, 0.68% and 42.09%, respectively. The apparent digestibility for growing Rex rabbits of GE, DM, CP, CF, NDF, ADF, EE, Ash, Ca, P and NFE of safflower meal were 62.60%, 61.72%, 62.39%, 15.68%, 26.30%, 14.75%, 80.69%, 38.35%, 59.35%, 31.98% and 79.61%, respectively, and those of milk thistle meal were 63.13%, 61.94%, 68.01%, 15.74%, 27.64%, 14.98%, 79.90%, 38.20%, 60.44%, 32.99% and 79.81%, respectively. In conclusion, there are certain differences between the apparent nutrient digestibility of safflower meal and milk thistle meal for growing Rex rabbits, and the nutritional value of safflower meal is close to milk thistle meal combined with the chemical analysis of feed ingredients, the 2 kinds of ingredients can be used as protein feed resource for Rex rabbits.