Molecular Nutrition

Effects of Glucose Metabolism and Utilization on Dairy Cows Production

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  • 1. Key Laboratory for Dairy Cow Nutrition, College of Animal Science and Technology, Beijing University of Agriculture, Beijing 102206, China;
    2. Key Laboratory of Molecular Animal Nutrition of Ministry of Education, Institute of Dairy Science, Zhejiang University, Hangzhou 310058, China

Received date: 2016-10-01

  Online published: 2017-03-09

Abstract

Glucose is not only the main energy substrate for brain cells of central nervous system and embryo in dairy cows, but also the lactose precursor and closely related to milk fat and milk protein synthesis, thus it has key nutritional physiological functions in lactating dairy cows. In order to improve milk performance and physiological health in lactating cows, it is necessary to study its physiological functions and metabolism in dairy cows. Therefore, the generation of glucose, glucose metabolism and utilization in the mammary gland, and the effects of glucose metabolism on dairy cows production were reviewed in order to further reveal the mechanism of glucose metabolic pathways across the whole body, promote the utilization of glucose and afford basic knowledge and references for dairy cow feeding.

Cite this article

WANG Bing, WANG Yue, JIANG Linshu, LIU Jianxin . Effects of Glucose Metabolism and Utilization on Dairy Cows Production[J]. Chinese Journal of Animal Nutrition, 2017 , 29(3) : 729 -738 . DOI: 10.3969/j.issn.1006-267x.2017.03.001

References

[1] SCOTT R,BAUMAN D E,CLARK J H.Cellular gluconeogenesis by lactating bovine mammary tissue[J].Journal of Dairy Science,1976,59(1):50-56.  

[2] THREADGOLD L C,KUHN N J.Glucose-6-phosphate hydrolysis by lactating rat mammary gland[J].International Journal of Biochemistry,1979,10(8):683-685.  

[3] 付聪,王洪荣,王梦芝,等.不同代谢葡萄糖水平饲粮对8-10月龄后备奶牛生长发育、营养物质消化率和血清生化指标的影响[J].动物营养学报,2014,26(9):2615-2622.

[4] 宋良荣,薛白,闫方权,等.饲粮代谢葡萄糖水平对热应激奶牛生产性能和生理指标的影响[J].动物营养学报,2014,26(6):1477-1485.

[5] KRONFELD D S.Major metabolic determinants of milk volume,mammary efficiency,and spontaneous ketosis in dairy cows[J].Journal of Dairy Science,1982,65(11):2204-2212.  

[6] RIGOUT S,LEMOSQUET S,VAN EYS J,et al.Duodenal glucose increases glucose fluxes and lactose synthesis in grass silage-fed dairy cows[J].Journal of Dairy Science,2002,85(3):595-606.  

[7] XIAO C T,QUINTON V M,CANT J P.Description of glucose transport in isolated bovine mammary epithelial cells by a three-compartment model[J].American Journal of Physiology:Cell Physiology,2004,286(4):C792-C797.

[8] STACEY A,SCHNIEKE A,KERR M,et al.Lactation is disrupted by alpha-lactalbumin deficiency and can be restored by human alpha-lactalbumin gene replacement in mice[J].Proceedings of the National Academy of Sciences of the United States of America,1995,92(7):2835-2839.  

[9] DAVIS S R,COLLIER R J.Mammary blood flow and regulation of substrate supply for milk synthesis[J].Journal of Dairy Science,1985,68(4):1041-1058.  

[10] CÁRDENAS M L,CORNISH-BOWDEN A,URETA T.Evolution and regulatory role of the hexokinases[J].Biochimica et Biophysica Acta:Molecular Cell Research,1998,1401(3):242-264.  

[11] ARMSTRONG D G,BLAXTER K L.Effects of acetic and propionic acids on energy retention and milk secretion in goats[C]//Proceedings of the 3rd Symposium on Energy Metabolism.London:Animal Production Publishing,59-68.

[12] 徐明,姚军虎.泌乳牛葡萄糖营养研究进展[J].动物营养学报,2005,17(3):1-5.

[13] OBA M,ALLEN M S.Extent of hypophagia caused by propionate infusion is related to plasma glucose concentration in lactating dairy cows[J].The Journal of Nutrition,2003,133(4):1105-1112.

[14] LEMOSQUET S,RAGGIO G,LOBLEY G E,et al.Whole-body glucose metabolism and mammary energetic nutrient metabolism in lactating dairy cows receiving digestive infusions of casein and propionic acid[J].Journal of Dairy Science,2009,92(12):6068-6082.  

[15] MIETTINEN H,HUHTANEN P.Effects of the ratio of ruminal propionate to butyrate on milk yield and blood metabolites in dairy cows[J].Journal of Dairy Science,1996,79(5):851-861.  

[16] WANG B,MAO S Y,YANG H J,et al.Effects of alfalfa and cereal straw as a forage source on nutrient digestibility and lactation performance in lactating dairy cows[J].Journal of Dairy Science,2014,97(12):7706-7715.  

[17] RODRÍGUEZ-PRADO M.在高精料日粮中添加辣椒提取物对育肥犊牛采食量、饮水量和瘤胃发酵的影响[J].王聪,译.中国畜牧兽医,2012,39(9):21.

[18] ARMENTANO L E.Ruminant hepatic metabolism of volatile fatty acids,lactate and pyruvate[J].The Journal of Nutrition,1992,122(3S):8386-842.

[19] GREENFIELD R B,CECAVA M J,DONKIN S S.Changes in mRNA expression for gluconeogenic enzymes in liver of dairy cattle during the transition to lactation[J].Journal of Dairy Science,2000,83(6):1228-1236.  

[20] RUKKWAMSUK T,WENSING T,GEELEN M J H.Effect of fatty liver on hepatic gluconeogenesis in periparturient dairy cows[J].Journal of Dairy Science,1999,82(3):500-505.  

[21] 王聪,刘强,张延利,等.丙二醇对奶牛围产期血浆激素和肝脏糖异生限速酶的影响[J].核农学报,2013,27(1):132-137.

[22] VELEZ J C,DONKIN S S.Feed restriction induces pyruvate carboxylase but not phosphoenolpyruvate carboxykinase in dairy cows[J].Journal of Dairy Science,2005,88(8):2938-2948.  

[23] WHITE H M,CARVALHO E R,KOSER S L,et al.Short communication:regulation of hepatic gluconeogenic enzymes by dietary glycerol in transition dairy cows[J].Journal of Dairy Science,2016,99(1):812-817.  

[24] ZHANG Q,KOSER S L,DONKIN S S.Propionate induces the bovine cytosolic phosphoenolpyruvate carboxykinase promoter activity[J].Journal of Dairy Science,2016,99(8):6654-6664.  

[25] WALKER C G,CROOKENDEN M A,HENTY K M,et al.Epigenetic regulation of pyruvate carboxylase gene expression in the postpartum liver[J].Journal of Dairy Science,2016,99(7):5820-5827.  

[26] 王炳.饲喂秸秆日粮奶牛泌乳性能低下的消化吸收与代谢机制研究[D].博士学位论文.杭州:浙江大学,2016.

[27] RHOADS R P,LA NOCE A J,WHEELOCK J B,et al.Short communication:alterations in expression of gluconeogenic genes during heat stress and exogenous bovine somatotropin administration[J].Journal of Dairy Science,2011,94(4):1917-1921.  

[28] BANGHAM A D,DE GIER J,GREVILLE G D.Osmotic properties and water permeability of phospholipid liquid crystals[J].Chemistry and Physics of Lipids,1967,1(3):225-246.  

[29] WIDDAS W F.The glucose transporter of human erythrocytes-working hypothesis for its functional mechanism[J].Experimental Physiology,1998,83(2):186-194.  

[30] ZHAO F Q,KEATING A F.Functional properties and genomics of glucose transporters[J].Current Genomics,2007,8(2):113-128.  

[31] WRIGHT E M,LOO D D F,HIRAYAMA B A.Biology of human sodium glucose transporters[J].Physiological Reviews,2011,91(2):733-794.  

[32] WRIGHT E M.Glucose transport families SLC5 and SLC50[J].Molecular Aspects of Medicine,2013,34(2/3):183-196.

[33] MUECKLER M,THORENS B.The SLC2(GLUT) family of membrane transporters[J].Molecular Aspects of Medicine,2013,34(2/3):121-138.

[34] ILLSLEY N P.Current topic:glucose transporters in the human placenta[J].Placenta,2000,21(1):14-22.  

[35] KLEPPER J,VOIT T.Facilitated glucose transporter protein type 1(GLUT1) deficiency syndrome:impaired glucose transport into brain-a review[J].European Journal of Pediatrics,2002,161(6):295-304.  

[36] ZHAO F Q.Biology of glucose transport in the mammary gland[J].Journal of Mammary Gland Biology and Neoplasia,2014,19(1):3-17.  

[37] 宗灿华,李庆章.不同发育时期奶牛乳腺葡萄糖转运蛋白1的表达与定位[J].黑龙江畜牧兽医,2013(11):11-13,188.

[38] ZHAO F Q,GLIMM D R,KENNELLY J J.Distribution of mammalian facilitative glucose transporter messenger RNA in bovine tissues[J].International Journal of Biochemistry,1993,25(12):1897-1903.  

[39] ZHAO F Q,DIXON W T,KENNELLY J J.Localization and gene expression of glucose transporters in bovine mammary gland[J].Comparative Biochemistry and Physiology Part B:Biochemistry and Molecular Biology,1996,115(1):127-134.  

[40] MILLER P J,FINUCANE K A,HUGHES M,et al.Cloning and expression of bovine glucose transporter GLUT12[J].Mammalian Genome,2005,16(11):873-883.  

[41] ZHAO F Q,MCFADDEN T B,WALL E H,et al.Cloning and expression of bovine sodium/glucose cotransporter SGLT2[J].Journal of Dairy Science,2005,88(8):2738-2748.  

[42] KOMATSU T,ITOH F,KUSHIBIKI S,et al.Changes in gene expression of glucose transporters in lactating and nonlactating cows[J].Journal of Animal Science,2005,83(3):557-564.  

[43] 赵珂.奶牛乳腺上皮细胞葡萄糖摄取的调控及其对乳成分合成的影响研究[D].博士学位论文.杭州:浙江大学,2011.

[44] NIELSEN M O,MADSEN T G,HEDEBOE A M.Regulation of mammary glucose uptake in goats:role of mammary gland supply,insulin,IGF-1 and synthetic capacity[J].The Journal of Dairy Research,2001,68(3):337-349.

[45] CANT J P,TROUT D R,QIAO F,et al.Milk synthetic response of the bovine mammary gland to an increase in the local concentration of arterial glucose[J].Journal of Dairy Science,2002,85(3):494-503.  

[46] ANNISON E F,LINZELL J L.The oxidation and utilization of glucose and acetate by the mammary gland of the goat in relation to their over-all metabolism and to milk formation[J].The Journal of Physiology,1964,175(3):372-385.  

[47] DELAMAIRE E,GUINARD-FLAMENT J.Increasing milking intervals decreases the mammary blood flow and mammary uptake of nutrients in dairy cows[J].Journal of Dairy Science,2006,89(9):3439-3446.  

[48] MILLER P S,REIS B L,CALVERT C C,et al.Patterns of nutrient uptake by the mammary glands of lactating dairy cows[J].Journal of Dairy Science,1991,74(11):3791-3799.  

[49] DOEPEL L,LAPIERRE H.Changes in production and mammary metabolism of dairy cows in response to essential and nonessential amino acid infusions[J].Journal of Dairy Science,2010,93(7):3264-3274.  

[50] LARSEN M,GALINDO C,OUELLET D R,et al.Abomasal amino acid infusion in postpartum dairy cows:effect on whole-body,splanchnic,and mammary amino acid metabolism[J].Journal of Dairy Science,2015,98(11):7944-7961.  

[51] DAVIS S R,COLLIER R J,MCNAMARA J P,et al.Effects of thyroxine and growth hormone treatment of dairy cows on mammary uptake of glucose,oxygen and other milk fat precursors[J].Journal of Animal Science,1988,66(1):80-89.  

[52] WANG B,SUN H Z,XU N N,et al.Amino acid utilization of lactating dairy cows when diets are changed from an alfalfa-based diet to cereal straw-based diets[J].Animal Feed Science and Technology,2016,217:56-66.

[53] RAMAKRISHNAN B,QASBA P K.Crystal structure of lactose synthase reveals a large conformational change in its catalytic component,the β1,4-galactosyltransferase-Ⅰ[J].Journal of Molecular Biology,2001,310(1):205-218.  

[54] JAHREIS K,PIMENTEL-SCHMITT E F,BRÜCKNER R,et al.Ins and outs of glucose transport systems in eubacteria[J].FEMS Microbiology Reviews,2008,32(6):891-907.  

[55] POLAKOF S,MOMMSEN T P,SOENGAS J L.Glucosensing and glucose homeostasis:from fish to mammals[J].Comparative Biochemistry and Physiology Part B:Biochemistry and Molecular Biology,2011,160(4):123-149.  

[56] BAUMAN D E,CURRIE W B.Partitioning of nutrients during pregnancy and lactation:a review of mechanisms involving homeostasis and homeorhesis[J].Journal of Dairy Science,1980,63(9):1514-1529.  

[57] RELLING A E,CROMPTON L A,LOERCH S C,et al.Short communication:plasma concentration of glucose-dependent insulinotropic polypeptide may regulate milk energy production in lactating dairy cows[J].Journal of Dairy Science,2014,97(4):2440-2443.  

[58] PETERS B J,RILLEMA J A.Effect of prolactin on 2-deoxyglucose uptake in mouse mammary gland explants[J].The American Journal of Physiology:Endocrinology and Metabolism,1992,262(5):E627-E630.

[59] TANWATTANA P,CHANPONGSANG S,CHAIYABUTR N.Effects of exogenous bovine somatotropin on mammary function of late lactating crossbred Holstein cows[J].Asian Australasian Journal of Animal Sciences,2003,16(1):88-95.  

[60] SHAO Y,WALL E H,MCFADDEN T B,et al.Lactogenic hormones stimulate expression of lipogenic genes but not glucose transporters in bovine mammary gland[J].Domestic Animal Endocrinology,2013,44(2):57-69.  

[61] GÁSPÁRDY A,SCHWARTZ Z,ZÖLDÁG L,et al.Changes in daily energy amounts of main milk components (lactose,protein and fat) during the lactation of high-yielding dairy cows[J].Acta Veterinaria Hungarica,2004,52(4):457-467.  

[62] OSHIMA M,FUSE H,ISHII T.Decrease in electrolyte concentration and changes in lactose and solids content of cows milk after treatment with thyroxine[J].Japanese Journal of Zootechnical Science,1980,51(11):772-778.

[63] PEAKER M.Ion and Water Transport in the Mammary Gland[M]//LARSON B L.The mammary gland/human lactation/milk Synthesis.New York:Aademic Press,1978:437-462.

[64] LARSEN M,LUND P,WEISBJERG M R,et al.Digestion site of starch from cereals and legumes in lactating dairy cows[J].Animal Feed Science and Technology,2009,153(3/4):236-248.

[65] GARNSWORTHY P C,FOULADI-NASHTA A A,MANN G E,et al.Effect of dietary-induced changes in plasma insulin concentrations during the early post partum period on pregnancy rate in dairy cows[J].Reproduction,2009,137(4):759-768.  

[66] MUNGÓI M,FLORES C,CASALS R,et al.Effect of malate and starch source on digestibility and nutrient balance of growing-fattening lambs[J].Animal Feed Science and Technology,2012,174(3/4):154-162.

[67] HARMON D L.Understanding starch utilization in the small intestine of cattle[J]. Asian-Australasian Journal of Animal Sciences,2009,22(7):915-922.  

[68] XU M,DU S,WANG J,et al.Influence of rumen escape starch on pancreatic exocrine secretion of goats[J].Journal of Animal Physiology and Animal Nutrition,2009,93(1):122-129.  

[69] CROZIER S J,SANS M D,LANG C H,et al.CCK-induced pancreatic growth is not limited by mitogenic capacity in mice[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2008,294(5):G1148-G1157.

[70] MIKU?A R,NOWAK W,JASKOWSKI J M,et al.Effects of different starch sources on metabolic profile,production and fertility parameters in dairy cows[J].Polish Journal of Veterinary Sciences,2011,14(1):55-64.

[71] 孙菲菲,曹阳春,姚军虎.奶牛围产期葡萄糖营养平衡及其调控研究进展[J].饲料工业,2013,34(15):46-50.

[72] SORDILLO L M,CONTRERAS G A,AITKEN S L.Metabolic factors affecting the inflammatory response of periparturient dairy cows[J].Animal Health Research Reviews,2009,10(1):53-63.  

[73] 李妍,薛倩,高艳霞,等.瘤胃保护葡萄糖对围产后期荷斯坦奶牛生产性能及血清生化指标的影响[J].畜牧兽医学报,2016,47(1):113-119.

[74] PIEPER L,STAUFENBIEL R,CHRIST J,et al.Heritability of metabolic response to the intravenous glucose tolerance test in German Holstein Friesian bulls[J].Journal of Dairy Science,2016,99(9):7240-7246.  

[75] MANN S,YEPES F A L,DUPLESSIS M,et al.Dry period plane of energy:effects on glucose tolerance in transition dairy cows[J].Journal of Dairy Science,2016,99(1):701-717.  

[76] WEBER C,SCHÄFF C T,KAUTZSCH U,et al.Insulin-dependent glucose metabolism in dairy cows with variable fat mobilization around calving[J].Journal of Dairy Science,2016,99(8):6665-6679.  
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