[1] LEVY S B,MARSHALL B.Antibacterial resistance worldwide:causes,challenges and responses[J].Nature Medicine,2004,10:122-129.
[2] LEVY S B.Microbial resistance to antibiotics:an evolving and persistent problem[J].The Lancet,1982,320(8289):83-88.

[3] SLAVIN J.Fiber and prebiotics:mechanisms and health benefits[J].Nutrients,2013,5(4):1417-1435.

[4] NRC.Nutrient requirements of swine[S].Washington,D.C.:National Academies Press,1998.
[5] DE LANGE C F M,PLUSKE J,GONG J,et al.Strategic use of feed ingredients and feed additives to stimulate gut health and development in young pigs[J].Livestock Science,2010,134(1/2/3):124-134.
[6] KNUDSEN K E B,HEDEMANN M S,LAERKE H N.The role of carbohydrates in intestinal health of pigs[J].Animal Feed Science and Technology,2012,173(1/2):41-53.
[7] WENK C.The role of dietary fibre in the digestive physiology of the pig[J].Animal Feed Science and Technology,2001,90(1/2):21-33.
[8] BUTTRISS J L,STOKES C S.Dietary fibre and health:an overview[J].Nutrition Bulletin,2008,33(3):186-200.

[9] TROWELL H.Definition of dietary fiber and hypotheses that it is a protective factor in certain diseases[J].The American Journal of Clinical Nutrition,1976,29(4):417-427.
[10] 卢德勋.日粮纤维的营养作用及其利用//刘建新,张宏福,王康宁.饲料营养研究进展[M].澳门:亚洲中医药杂志社,1998:13-241.
[11] MUDGIL D,BARAK S.Composition,properties and health benefits of indigestible carbohydrate polymers as dietary fiber:a review[J].International Journal of Biological Macromolecules,2013,61:1-6.
[12] KNUDSEN K E B.The nutritional significance of "dietary fibre" analysis[J].Animal Feed Science and Technology,2001,90(1/2):3-20.
[13] KELKAR S,SIDDIQ M,HARTE J B,et al.Use of low-temperature extrusion for reducing phytohemagglutinin activity (PHA) and oligosaccharides in beans (Phaseolus vulgaris L.) cv. Navy and Pinto[J].Food Chemistry,2012,133(4):1636-1639.

[14] VAN SOEST P V,ROBERTSON J B,LEWIS B.Methods for dietary fiber,neutral detergent fiber,and nonstarch polysaccharides in relation to animal nutrition[J].Journal of Dairy Science,1991,74(10):3583-3597.

[15] ESPOSITO F,ARLOTTI G,BONIFATI A M,et al.Antioxidant activity and dietary fibre in durum wheat bran by-products[J].Food Research International,2005,38(10):1167-1173.

[16] LUNN J,BUTTRISS J.Carbohydrates and dietary fibre[J].Nutrition Bulletin,2007,32(1):21-64.

[17] WELLOCK I J,HOUDIJK J G K,KYRIAZAKIS I.Effect of dietary non-starch polysaccharide solubility and inclusion level on gut health and the risk of post weaning enteric disorders in newly weaned piglets[J].Livestock Science,2007,108(1/2/3):186-189.
[18] DIKEMAN C L,FAHEY G C,Jr.Viscosity as related to dietary fiber:a review[J].Critical Reviews in Food Science and Nutrition,2006,46(8):649-663.

[19] CHOCT M.Feed non-starch polysaccharides:chemical structures and nutritional significance[J].Feed Milling International,1997:13-26.
[20] JHA R,LETERME P.Feed ingredients differing in fermentable fibre and indigestible protein content affect fermentation metabolites and faecal nitrogen excretion in growing pigs[J].The Animal Consortium,2012,6(4):603-611.
[21] JHA R,ROSSNAGEL B,PIEPER R,et al.Barley and oat cultivars with diverse carbohydrate composition alter ileal and total tract nutrient digestibility and fermentation metabolites in weaned piglets[J].The Animal Consortium,2010,4(5):724-731.
[22] JHA R,OWUSU-ASIEDU A,SIMMINS P H,et al.Degradation and fermentation characteristics of wheat coproducts from flour milling in the pig intestine studied in vitro[J].Journal of Animal Science,2012,90 Suppl 4:173-175.
[23] NOBLET J,LE GOFF G.Effect of dietary fibre on the energy value of feeds for pigs[J].Animal Feed Science and Technology,2001,90(1):35-52.
[24] JHA R,BERROCOSO J D.Review:dietary fiber utilization and its effects on physiological functions and gut health of swine[J].Animal,2015,9(9):1441-1452.

[25] SERENA A,HEDEMANN M S,BACH KNUDSEN K E.Influence of dietary fiber on luminal environment and morphology in the small and large intestine of sows[J].Journal of Animal Science,2008,86(9):2217-2227.

[26] 杨玉芬,卢德勋,许梓荣.日粮纤维对仔猪生长性能和消化生理功能的影响[J].动物营养学报,2009,21(6):816-821.
[27] JASLEEN J,ASHLEY S W,SHIMODA N,et al.Glucagon-like peptide 2 stimulates intestinal epithelial proliferation in vitro[J].Digestive Diseases and Sciences,2002,47(5):1135-1140.

[28] MAZZONI M,LE GALL M,DE FILIPPI S,et al.Supplemental sodium butyrate stimulates different gastric cells in weaned pigs[J].The Journal of Nutrition,2008,138(8):1426-1431.
[29] ARGENZIO R A,WHIPP S C.Inter-relationship of sodium,chloride,bicarbonate and acetate transport by the colon of the pig[J].The Journal of Physiology,1979,295(1):365-381.

[30] CHEN H,MAO X,YIN J,et al.Comparison of jejunal digestive enzyme activities,expression of nutrient transporter genes,and apparent fecal digestibility in weaned piglets fed diets with varied sources of fiber[J].Journal of Animal and Feed Sciences,2015,24(1):41-47.

[31] SAKATA T,INAGAKI A.Organic acid production in the large intestine:implication for epithelial cell proliferation and cell death[M]//PIVA A, BACH KNUDSEN K E, LINDBERG J E.The gut environment of pigs.Nottingham:Nottingham University Press,2001:85-94.
[32] 李可洲,李宁,黎介寿,等.短链脂肪酸对大鼠移植小肠形态及功能的作用研究[J].世界华人消化杂志,2002,10(6):720-722.
[33] RENTERIA-FLORES J A,JOHNSTON L J,SHURSON G C,et al.Effect of soluble and insoluble fiber on energy digestibility,nitrogen retention,and fiber digestibility of diets fed to gestating sows[J].Journal of Animal Science,2008,86(10):2568-2575.

[34] URRIOLA P E.Digestibility of dietary fiber by growing pigs[D].Ph.D.Thesis.Urbana-Champaign:University of Illinois,2010.
[35] ZEBROWSKA T,LOW A G,ZEBROWSKA H.Studies on gastric digestion of protein and carbohydrate,gastric secretion and exocrine pancreatic secretion in the growing pig[J].British Journal of Nutrition,1983,49(3):401-410.
[36] CHEN L,ZHANG H F,GAO L X,et al.Effect of graded levels of fiber from alfalfa meal on intestinal nutrient and energy flow,and hindgut fermentation in growing pigs[J].Journal of Animal Science,2013,91(10):4757-4764.

[37] CHEN L,GAO L X,ZHANG H F.Effect of graded levels of fiber from alfalfa meal on nutrient digestibility and flow of fattening pigs[J].Journal of Integrative Agriculture,2014,13(8):1746-1752.

[38] GAO L X,CHEN L,HUANG Q H,et al.Effect of dietary fiber type on intestinal nutrient digestibility and hindgut fermentation of diets fed to finishing pigs[J].Livestock Science,2015,174:53-58.
[39] 孟丽辉,庞敏,朱丽媛,等.日粮纤维来源对生长猪养分消化率的影响[J].动物营养学报,2015,27(4):1068-1075.
[40] MONTAGNE L,PLUSKE J R,HAMPSON D J.A review of interactions between dietary fibre and the intestinal mucosa,and their consequences on digestive health in young non-ruminant animals[J].Animal Feed Science and Technology,2003,108(1/2/3/4):95-117.
[41] MASLOWSKI K M,MACKAY C R.Diet,gut microbiota and immune responses[J].Nature Immunology,2011,12(1):5-9.

[42] LINDBERG J E.Fiber effects in nutrition and gut health in pigs[J].Journal of Animal Science and Biotechnology,2014,5:15.
[43] ZOETENDAL E G,COLLIER C T,KOIKE S,et al.Molecular ecological analysis of the gastrointestinal microbiota:a review[J].The Journal of Nutrition,2004,134(2):465-472.
[44] KNUDSEN K E B,HANSEN I.Gastrointestinal implications in pigs of wheat and oat fractions[J].British Journal of Nutrition,1991,65(2):217-232.

[45] VAREL V H,POND W G,PEKAS J C,et al.Influence of high-fiber diet on bacterial populations in gastrointestinal tracts of obese-and lean-genotype pigs[J].Applied and Environmental Microbiology,1982,44(1):107-112.
[46] WILLIAMS B A,VERSTEGEN M W A,TAMMINGA S.Fermentation in the large intestine of single-stomached animals and its relationship to animal health[J].Nutrition Research Reviews,2001,14(2):207-228.

[47] DREW M D,VAN KESSEL A G,ESTRADA A E,et al.Effect of dietary cereal on intestinal bacterial populations in weaned pigs[J].Canadian Journal of Animal Science,2002,82(4):607-609.

[48] NIELSEN T S,LAERKE H N,THEIL P K,et al.Diets high in resistant starch and arabinoxylan modulate digestion processes and SCFA pool size in the large intestine and faecal microbial composition in pigs[J].British Journal of Nutrition,2014,112(11):1837-1849.

[49] MCDONALD D E,PETHICK D W,PLUSKE J R,et al.Adverse effects of soluble non-starch polysaccharide (guar gum) on piglet growth and experimental colibacillosis immediately after weaning[J].Research in Veterinary Science,1999,67(3):245-250.

[50] LIU H,IVARSSON E,DICKSVED J,et al.Inclusion of chicory (Cichorium intybus L.) in pigs' diets affects the intestinal microenvironment and the gut microbiota[J].Applied and environmental microbiology,2012,78(12):4102-4109.

[51] HAENEN D,DA SILVA C S,ZHANG J,et al.Resistant starch induces catabolic but suppresses immune and cell division pathways and changes the microbiome in the proximal colon of male pigs[J].The Journal of Nutrition,2013,143(12):1889-1898.

[52] HAENEN D,ZHANG J,DA SILVA C S,et al.A diet high in resistant starch modulates microbiota composition,SCFA concentrations,and gene expression in pig intestine[J].The Journal of Nutrition,2013,143(3):274-283.

[53] HAMAKER B R,TUNCIL Y E.A perspective on the complexity of dietary fiber structures and their potential effect on the gut microbiota[J].Journal of Molecular Biology,2014,426(23):3838-3850.

[54] GIBSON G R,ROBERFROID M B.Dietary modulation of the human colonic microbiota:introducing the concept of prebiotics[J]. The Journal of Nutrition,1995,125(6):1401-1412.
[55] BOUHNIK Y,RASKINE L,SIMONEAU G,et al.The capacity of nondigestible carbohydrates to stimulate fecal bifidobacteria in healthy humans:a double-blind,randomized,placebo-controlled,parallel-group,dose-response relation study[J].The American Journal of Clinical Nutrition,2004,80(6):1658-1664.
[56] FREIRE J P B,GUERREIRO A J G,CUNHA L F,et al.Effect of dietary fibre source on total tract digestibility,caecum volatile fatty acids and digestive transit time in the weaned piglet[J].Animal Feed Science and Technology,2000,87(1/2):71-83.
[57] HEDEMANN M S,ESKILDSEN M,LAERKE H N,et al.Intestinal morphology and enzymatic activity in newly weaned pigs fed contrasting fiber concentrations and fiber properties[J].Journal of Animal Science,2006,84(6):1375-1386.

[58] WELLOCK I J,FORTOMARIS P D,HOUDIJK J G,et al.The consequences of non-starch polysaccharide solubility and inclusion level on the health and performance of weaned pigs challenged with enterotoxigenic Escherichia coli[J].British Journal of Nutrition,2008,99(3):520-530.
[59] TOPPING D L,CLIFTON P M.Short-chain fatty acids and human colonic function:roles of resistant starch and nonstarch polysaccharides[J].Physiological Reviews,2001,81(3):1031-1064.
[60] TREMAROLI V,BÄCKHED F.Functional interactions between the gut microbiota and host metabolism[J].Nature,2012,489(7415):242-249.

[61] ICHIMURA A,HIRASAWA A,HARA T,et al.Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis[J].Prostaglandins & Other Lipid Mediators,2009,89(3/4):82-88.
[62] KAJI I,KARAKI S I,TANAKA R,et al.Density distribution of free fatty acid receptor 2(FFA2)-expressing and GLP-1-producing enteroendocrine L cells in human and rat lower intestine,and increased cell numbers after ingestion of fructo-oligosaccharide[J].Journal of Molecular Histology,2011,42(1):27-38.

[63] SAMUEL B S,SHAITO A,MOTOIKE T,et al.Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor,Gpr41[J].Proceedings of the National Academy of Sciences of the United States of America,2008,105(43):16767-16772.

[64] CLAUS R,GÜNTHNER D,LETZGUSS H.Effects of feeding fat-coated butyrate on mucosal morphology and function in the small intestine of the pig[J].Journal of Animal Physiology and Animal Nutrition,2007,91(7/8):312-318.
[65] VINOLO M A,RODRIGUES H G,HATANAKA E,et al.Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils[J].The Journal of Nutritional Biochemistry,2011,22(9):849-855.

[66] VINOLO M A R,RODRIGUES H G,NACHBAR R T,et al.Regulation of inflammation by short chain fatty acids[J].Nutrients,2011,3(10):858-876.
[67] NICHOLSON J K,HOLMES E,KINROSS J,et al.Host-gut microbiota metabolic interactions[J].Science,2012,336(6086):1262-1267.

[68] KIM M H,KANG S G,PARK J H,et al.Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice[J].Gastroenterology,2013,145(2):396-406.

[69] WANG R L,HOU Z P,WANG B,et al.Effects of feeding galactomannan oligosaccharides on growth performance,serum antibody levels and intestinal microbiota in newly-weaned pigs[J].Journal of Food,Agriculture & Environment,2010,8(3/4):47-55.
[70] TANG Z R,YIN Y L,NYACHOTI C M,et al.Effect of dietary supplementation of chitosan and galacto-mannan-oligosaccharide on serum parameters and the insulin-like growth factor-I mRNA expression in early-weaned piglets[J].Domestic Animal Endocrinology,2005,28(4):430-441.

[71] RAMSAY A J,HUSBAND A J,RAMSHAW I A,et al.The role of interleukin-6 in mucosal IgA antibody responses in vivo[J].Science,1994,264(5158):561-563.

[72] BAI Z B,ZHANG Z T,YE Y J,et al.Sodium butyrate induces differentiation of gastric cancer cells to intestinal cells via the PTEN/phosphoinositide 3-kinase pathway[J].Cell Biology International,2010,34(12):1141-1145.

[73] VARUM F J O,VEIGA F,SOUSA J S,et al.An investigation into the role of mucus thickness on mucoadhesion in the gastrointestinal tract of pig[J].European Journal of Pharmaceutical Sciences,2010,40(4):335-341.

[74] CHEN H,WANG W,DEGROOTE J,et al.Arabinoxylan in wheat is more responsible than cellulose for promoting intestinal barrier function in weaned male piglets[J].The Journal of Nutrition,2015,145(1):51-58.

[75] CABOTAJE L M,SHINNICK F L,LOPÉZ-GUISA J M,et al.Mucin secretion in germfree rats fed fiber-free and psyllium diets and bacterial mass and carbohydrate fermentation after colonization[J].Applied and Environmental Microbiology,1994,60(4):1302-1307.
[76] SCHMIDT-WITTIG U,ENSS M L,COENEN M,et al.Response of rat colonic mucosa to a high fiber diet[J].Annals of Nutrition & Metabolism,1996,40(6):343-350.

[77] CHE L Q,CHEN H,YU B,et al.Long-Term intake of pea fiber affects colonic barrier function,bacterial and transcriptional profile in pig model[J].Nutrition and Cancer,2014,66(3):388-399.

[78] HATAYAMA H,IWASHITA J,KUWAJIMA A,et al.The short chain fatty acid,butyrate,stimulates MUC2 mucin production in the human colon cancer cell line,LS174T[J].Biochemical and Biophysical Research Communications,2007,356(3):599-603.

[79] BARCELO A,CLAUSTRE J,MORO F,et al.Mucin secretion is modulated by luminal factors in the isolated vascularly perfused rat colon[J].Gut,2000,46(2):218-224.

[80] LIU H Y,LUNDH T,DICKSVED J,et al.Expression of heat shock protein 27 in gut tissue of growing pigs fed diets without and with inclusion of chicory fiber[J].Journal of Animal Science,2012,90 Suppl 4:25-27.