[1] LEVINE B,KROEMER G.Autophagy in the pathogenesis of disease[J].Cell,2008,132(1):27-42.
[2] 陈琼.仔猪早期断奶应激诱导自噬发生规律的研究[D].硕士学位论文.武汉:华中农业大学.2013.
[3] ZONCU R,EFEYAN A,SABATINI D M.mTOR:From growth signal integration to cancer,diabetes and ageing[J].Nature Reviews Molecular Cell Biology,2011,12(1):21-35.
[4] SHINTANI T,KLIONSKY D J.Autophagy in health and disease:a double-edged sword[J].Science,2004,306(5698):990-995.
[5] TIAN F,DEGUCHI K,YAMASHITA T,et al.In vivo imaging of autophagy in a mouse stroke model[J].Autophagy,2010,6(8):1107-1114.
[6] JUNG C H,JUN C B,RO S H,et al.ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery[J].Molecular Biology of the Cell,2009,20(7):1992-2003.
[7] GOTTLIEB RA,CARREIRA RS.Autophagy in health and disease.5.Mitophagy as a way of life[J].American Journal of Physiology:Cell Physiology,2010,299(2):C203-C210.
[8] JUNG C H,RO S H,CAO J,et al.mTOR regulation of autophagy[J].FEBS Letters,2010,584(7):1287-1295.
[9] SURYAWAN A,DAVIS T A.The abundance and activation of mTORC1 regulators in skeletal muscle of neonatal pigs are modulated by insulin,amino acids,and age[J].Journal of Applied Physiology,2010,109(5):1448-1454.
[10] SANCAK Y,BAR-PELED L,ZONCU R,et al.Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids[J].Cell,2010,141(2):290-303.
[11] KIM J,KUNDU M,VIOLLET B,et al.AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1[J].Nature Cell Biology,2011,13(2):132-141.
[12] 许丹丹,何艮.氨基酸感知与代谢调控的研究进展[J].动物营养学报,2015,27(2):342-351.
[13] 高源,吴更.mTORC1通路中氨基酸信号转导相关机制研究进展[J].中国细胞生物学学报,2012,34(8):812-818.
[14] EFEYAN A,ZONCU R,CHANG S,et al.Rag GTPase-mediated regulation of mTORC1 by nutrients is necessary for neonatal autophagy and survival[J].Nature,2013,493(7434):679-683.
[15] HOSOKAWA N,SASAKI T,IEMURA S,et al.Atg101,a novel mammalian autophagy protein interacting with Atg13[J].Autophagy,2009,5(7):973-979.
[16] 王慧俐,邱龄,李艳芳.血浆必需氨基酸浓度与细胞自噬程度相关性分析[J].山西医科大学学报,2010,41(4):288-291.
[17] 朱玉华,薛欣合,周天骄,等.谷氨酰胺、精氨酸和亮氨酸缺乏诱导猪肠道上皮细胞自噬的研究[C]//中国畜牧兽医学会动物营养学分会第十一次全国动物营养学术研讨会论文集.长沙:中国畜牧兽医学会,2012.
[18] YAN X H,SUN Q M,JI J,et al.Reconstitution of leucine-mediated autophagy via the mTORC1-Barkor pathway in vitro[J].Autophagy,2012,8(2):213-221.
[19] DODD K M,TEE A R.Leucine and mTORC1:a complex relationship[J].American Journal of Physiology-Endocrinology and Metabolism,2012,302(11):E1329-E1342.
[20] KIM E,GORAKSHA-HICKS P,LI L,et al.Regulation of TORC1 by Rag GTPases in nutrient response[J].Nature Cell Biology,2008,10(8):935-945.
[21] ZHANG T L,PÉLI-GULLI M P,YANG H,et al.Ego3 functions as a homodimer to mediate the interaction between Gtrl-Gtr2 and Ego1 in the EGO complex to activate TORC1[J].Structure,2012,20(12):2151-2160.
[22] JEONG J H,LEE Y M,KIM D H.et al.Crystal structure of the Gtr1p (GTP)-Gtr2p(GDP) protein complex reveals large structural rearrangements triggered by GTP-to-GDP conversion[J].The Journal of Biological Chemistry,2012,287(35):29648-29653.
[23] BAR-PELED L,SCHWEITZER L D,ZONCU R,et al.Ragulator is a GEF for the Rag GTPases that signal Amino Acid Levels to mTORC1[J].Cell,2012,150(6):1196-1208.
[24] SANCAKY,PETERSON T R,SHAUL Y D,et.al.The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1[J].Science,2008,320(5882):1496-1501.
[25] TEE A R,MANNING B D,ROUX P P,et al.Tuberous sclerosis complex gene products,Tuberin and Hamartin,control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb[J].Current Biology,2003,13(15):1259-1268.
[26] HAN J M,JEONG S J,PARK M C,et al.Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway[J].Cell,2012,149(2):410-424.
[27] RUI G,LI L,YI L,et al.Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation[J].Genes & Development,2011,25(16):1668-1673.
[28] SEGEV N,HAY N.Hijackingleucyl-tRNA synthetase for amino acid-dependent regulation of TORC1[J].Molecular Cell,2012,46(1):4-6.
[29] WU H,WANG F L,HU S L,et al.MiR-20a and miR-106b negatively regulate autophagy induced by leucine deprivation via suppression of ULK1 expression in C2C12 myoblasts[J].Cellular Signaling,2012,24(11):2179-2186.
[30] KLIONSKY D J,ABELIOVICH H,AGOSTINIS P,et al.Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes[J].Autophagy,2008,4(2):151-175.
