Molecular Nutrition

Effects of Lentinan Supplementation on Growth Performance, Antioxidant Capacity and Intestinal Health of Weaned Rats

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  • Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education, Chengdu 611130, China

Received date: 2016-09-04

  Online published: 2017-03-09

Abstract

This experiment was conducted to determine the effects of lentinan supplementation on growth performance, antioxidant capacity and intestinal health of weaned rats. Twenty healthy weaned Wistar rats, based on the similar body weight, were randomly assigned to two group with each group has 10 rats. The rats in those two groups were fed a basal diet and a experimental diet supplemented with 84 mg/kg lentinan (the effective content of lentinan was 30%), respectively. The experiment duration was 21 d. The results showed that diet supplemented with 84 mg/kg lentinan significantly increased average daily gain and average daily feed intake (P<0.05), and significantly decreased feed to gain ratio of weaned rats (P<0.05). Diet supplemented with 84 mg/kg lentinan significantly enhanced the total antioxidant capacity in serum and jejunum (P<0.05), and reduced the malondialdehyde content in serum (P<0.05) and jejunum (P=0.08) of weaned rats in different degrees. Diet supplemented with 84 mg/kg lentinan also significantly increased the villus height and the villus height/crypt depth of jejunum of weaned rats (P<0.05). In addition, diet supplemented with 84 mg/kg lentinan increased the Lactobacillus number in cecal digesta (P=0.07), significantly reduced the Escherichia coli number in cecal digesta (P<0.05), and significantly increased the contents of acetate, propionate, butyrate and total volatile fatty acids in cecal digesta of weaned rats (P<0.05). These results suggest that diet supplemented with 84 mg/kg lentinan can improve the antioxidant capacity, jejunal mucosal morphology and cecal microbiota structure, and then increase the growth performance of weaned rats.

Cite this article

MAO Xiangbing, CHEN Daiwen, HU Haiyan, YU Bing, GU Changsong, HE Jun, YU Jie, LUO Junqiu, LUO Yuheng, ZHENG Ping . Effects of Lentinan Supplementation on Growth Performance, Antioxidant Capacity and Intestinal Health of Weaned Rats[J]. Chinese Journal of Animal Nutrition, 2017 , 29(3) : 859 -865 . DOI: 10.3969/j.issn.1006-267x.2017.03.016

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