This research aimed to study the effects of different combination of mesh size of screen, conditioning temperature and diameter of die hole on processing quality of pellet feed, growth performance and nutrient apparent digestibility of broilers. A common corn-soybean meal type diet for broilers was used in this experiment, and under the same recipe and slenderness ratio of die hole, a pellet feed processing test with 3 factors of 2 levels (mesh size of screen was 2.0 and 2.5 mm, conditioning temperature was 70 and 80℃, and diameter of die hole was 3 and 4 mm) was designed. A total of 864 one-day-old Arbor Acres broilers were randomly divided to 8 treatments with 6 replicates each and 18 broilers per replicate. The feeding experiment lasted for 42 days consisting of 2 stages with 1 to 21 days and 22 to 42 days of age. The results show as follows:1) the pellet hardness was significantly affected by the interaction of screen mesh size and diameter of die hole and the interaction of diameter of die hole and conditioning temperature (P<0.01). The pellet durability index (PDI) was significantly affected by interaction of diameter of die hole and conditioning temperature, the interaction of screen mesh size and conditioning temperature and the interaction of screen mesh size, conditioning temperature and diameter of die hole (P<0.01). The PDI was significantly affected by the interaction of screen mesh size and diameter of die hole (P<0.05). 2) The final body weight, average daily gain and average daily feed intake of broilers of 1 to 21 days of age were significantly affected by conditioning temperature (P<0.01). The final body weight of broilers of 22 to 42 days of age was significantly affected by conditioning temperature (P<0.01), too. 3) Nutrient apparent digestibility of broilers of 1 to 21 days of age was not significantly affected by screen mesh size, conditioning temperature and the interaction of both (P>0.05). While apparent digestibility of dry matter, energy and crude protein of broilers of 22 to 42 days of age were significantly affected by the interaction of screen mesh size, conditioning temperature and diameter of die hole (P<0.01). In conclusion, under the same screen mesh size and diameter of die hole, pellet hardness and PDI were increased with the conditioning temperature increasing. Under the same screen mesh size and conditioning temperature, pellet hardness and PDI were decreased with the diameter of die hole increasing. Growth performance of broilers of 1 to 21 days of age was increased with conditioning temperature increasing which showed significantly higher under 70℃ than 80℃ whatever screen mesh size was 2.0 or 2.5 mm, and the ratio of feed to gain was decreased with conditioning temperature increasing with the same tendency. Growth performance and the ratio of feed to gain of broilers of 22 to 42 days of age showed a better value when screen mesh size was 2.0 or 2.5 mm, conditioning temperature was 70℃ and diameter of die hole was 4.0 mm. Growth performance and the ratio of feed to gain of broilers of 1 to 42 days of age showed a better value when screen mesh size was 2.0 or 2.5 mm, conditioning temperature was 70℃ and diameter of die hole was 4.0 mm. Apparent digestibility of dry matter, energy and crude protein of broilers of 1 to 21 days of age showed a better value when screen mesh size was 2.5 mm and conditioning temperature was 80℃. Apparent digestibility of dry matter, energy and crude protein of broilers of 22 to 42 days of age showed a better value when screen mesh size was 2.5 mm, conditioning temperature was 70℃ and diameter of die hole was 4.0 mm.