Molecular Nutrition

Intestinal Immune Tolerance Mechanism of Symbiotic Microorganisms

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  • Institute of Dairy Science, Zhejiang University, Hangzhou 310058, China

Received date: 2016-11-04

  Online published: 2017-05-13

Abstract

There are millions of microorganisms in the intestine of animals. These symbiotic microorganisms can assist digestion and metabolism of organisms and maintain intestinal stability. However, the microorganisms and their metabolites can also serve as an antigen affect the normal function of the intestine. Under normal circumstances, the intestinal immune system can accurately identify symbiotic microorganisms and their metabolites to make immune tolerance and maintain the stability of the internal environment. On the other hand, it avoids reaction to harmless antigens caused by the waste of immune resources. Immune tolerance has been widely used in clinical medicine to reduce the occurrence of rejection after organ transplantation and decrease uterine immune rejection of the fetus. However, there is little report on how to use the immune tolerance mechanism to reduce the rumen acidosis of ruminants and improve the synthesis and utilization efficiency of ruminal microbial protein, and to improve the feeding regulations of probiotics. Therefore, this review describes the general concepts and applications of immune tolerance, the composition and function of the intestinal immune system, the immunogenicity of intestinal symbiotic microorganisms and the mechanisms of intestinal immune tolerance.

Cite this article

LE Jiaqing, WANG Jiakun . Intestinal Immune Tolerance Mechanism of Symbiotic Microorganisms[J]. Chinese Journal of Animal Nutrition, 2017 , 29(5) : 1489 -1497 . DOI: 10.3969/j.issn.1006-267x.2017.05.006

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