Effects of Glutamine on Growth Performance and Serum Biochemical Parameters of Lipopolysaccharide Challenged Piglets

TIAN Junquan, HE Liuqin, HUANG Niu, LI Huan, CUI Zhijie, LI Si, YAO Kang

doi:10.3969/j.issn.1006-267x.2017.05.027

Chinese Journal of Animal Nutrition >

2017 , Vol. 29 >Issue 5: 1670 - 1677

DOI: https://doi.org/10.3969/j.issn.1006-267x.2017.05.027

Molecular Nutrition

Effects of Glutamine on Growth Performance and Serum Biochemical Parameters of Lipopolysaccharide Challenged Piglets

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1. Key Laboratory of Agro-Ecological Processes in Subtropical Region, Provincial Engineering Research Center of Healthy Livestock, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;
2. University of Chinese Academy of Sciences, Beijing 100049, China;
3. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China;
4. Xiangtan University, Xiangtan 411105, China

Received date: 2016-11-01

Online published: 2017-05-13

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Abstract

The objective of the study was to evaluate the effects of dietary glutamine (Gln) supplementation on growth performance in the different stages, and the effects of Gln on growth performance and serum biochemical parameters of weaned piglets after intestinal injury induced by lipopolysaccharide (LPS). Twenty-four cross-bred (Duroc×Landrace×Yorkshire) piglets weaned at 28 days of age were randomly assigned into 3 groups with 8 replicates per group and 1 pig per replicate. Pigs in the control group and LPS group were fed the basal diet, and the others in the Gln+LPS group were fed the basal diet supplemented with 1% exogenous Gln. On day 22, 25, 28 and 30 of the trial, piglets in the LPS and Gln+LPS groups were administered intraperitoneally with 100 μg/kg BW LPS, whereas pigs in the control group were injected intraperitoneally with the same volume of sterile saline. The experiment lasted for 30 days. The results showed as follows: 1) before LPS challenge (day 1 to 21 of the trial), compared with the control group, the average daily feed intake (ADFI) and average daily gain (ADG) of weaned piglets in Gln+LPS group were significantly increased on day 1 to 7 of the trial (P<0.05), the ADFI of weaned piglets in Gln+LPS group was significantly increased on day 8 to 14 and 1 to 21 of the trial (P<0.05). 2) After LPS challenge (day 22 to 30 of the trial), the ADFI, ADG and body weight on day 30 of weaned piglets in control group were significantly higher than those in LPS and Gln+LPS groups (P<0.05), the ADFI, ADG and body weight on day 30 of weaned piglets in Gln+LPS group were higher than those in LPS group (P>0.05). 3) The small intestine length of weaned piglets in LPS group was significantly lower than that in control and Gln+LPS groups (P<0.05), but there was no difference between the control group and Gln+LPS group (P>0.05). 4) Compared with the control group, the high density lipoprotein cholesterol content and alkaline phosphatase activity in serum of weaned piglets in Gln+LPS group were significantly decreased (P<0.05), but there was no difference between the Gln+LPS group and LPS group (P>0.05); the serum immunoglobulin M content of weaned piglets in Gln+LPS and LPS groups was significantly increased (P<0.05). The results indicate that dietary supplemented with 1% Gln can improve the growth performance of piglets after weaning 1 to 7 day, and then it is not obvious. Dietary supplemented with 1% Gln can regulate the serum biochemical parameters, improve the growth performance and small intestine length of piglets, thereby alleviate weaning stress.

Key words： glutamine; weaned piglets; LPS; growth performance; serum biochemical parameters

Cite this article

TIAN Junquan, HE Liuqin, HUANG Niu, LI Huan, CUI Zhijie, LI Si, YAO Kang . Effects of Glutamine on Growth Performance and Serum Biochemical Parameters of Lipopolysaccharide Challenged Piglets[J]. Chinese Journal of Animal Nutrition, 2017 , 29(5) : 1670 -1677 . DOI: 10.3969/j.issn.1006-267x.2017.05.027

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