Effects of Dietary Functional Compound Additive Supplementation on Growth Performance and Immune Function of Growing Pigs

WU Lijuan, MAO Xiangbing, YU Bing, HE Jun, HUANG Zhiqing, YU Jie, ZHENG Ping, LUO Junqiu, CHEN Daiwen

doi:10.3969/j.issn.1006-267x.2017.05.031

2017 , Vol. 29 >Issue 5: 1716 - 1722

DOI: https://doi.org/10.3969/j.issn.1006-267x.2017.05.031

Molecular Nutrition

Effects of Dietary Functional Compound Additive Supplementation on Growth Performance and Immune Function of Growing Pigs

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Institute of Animal Nutrition of Sichuan Agricultural University, Chengdu 611130, China

Received date: 2016-11-04

Online published: 2017-05-13

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Abstract

The aim of this experiment was to study the effects of dietary functional compound additive supplementation on growth performance and immune function of growing pigs. Twenty Duroc×Landrace×Large (DLY) healthy pigs with an initial body weight of (21.06±1.98) kg were randomly divided into two groups with 10 replicates per group and 1 pig per replicate. Pigs were fed the basal diet (control group) or the diet added 0.1% functional compound additive (additive group) for 14 days. The results showed that compared with the control group, dietary functional compound additive supplementation significantly increased the average daily gain (ADG) of growing pigs (P<0.05), significantly increased the serum interleukin-10 (IL-10) content of growing pigs (P<0.01), significantly reduced the serum urea nitrogen (UN) and interleukin-1 (IL-1) contents (P<0.05 or P<0.01), and significantly decreased the mRNA relative expressions of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), tumor necrosis factor receptor-associated factor 6 (TRAF6) and IL-1 receptor associated kinase 1 (IRAK1), which is the key genes of Toll-like receptor (TLR) pathway, in white blood cells of growing pigs (P<0.05 or P<0.01). Collectively, above results indicate that dietary functional compound additive supplementation can improve the growth performance via improving the utilization of protein and regulating the immune function of growing pigs.

Key words： growing pigs; functional compound additive; growth performance; immune function

Cite this article

WU Lijuan, MAO Xiangbing, YU Bing, HE Jun, HUANG Zhiqing, YU Jie, ZHENG Ping, LUO Junqiu, CHEN Daiwen . Effects of Dietary Functional Compound Additive Supplementation on Growth Performance and Immune Function of Growing Pigs[J]. Chinese Journal of Animal Nutrition, 2017 , 29(5) : 1716 -1722 . DOI: 10.3969/j.issn.1006-267x.2017.05.031

References

[1] WILBURN E E,MAHAN D C,HILL D,et al.An evaluation of natural (RRR-α-tocopheryl acetate) and synthetic (all-rac-α-tocopheryl acetate) vitamin E fortification in the diet or drinking water of weanling[J].Journal of Animal Science,2008,86(3):584-591.

[2] KONOWALCHUK J D,RIEGER A M,KIEMELE M D,et al.Modulation of weanling pig cellular immunity in response to diet supplementation with 25-hydroxy vitamin D₃[J].Veterinary Immunology and Immunopathology, 2013,155(1):57-66.

[3] ZHAO J,LI D,PIAO X,et al.Effects of vitamin C supplementation on performance,iron status and immune function of weaned piglets[J].Archiv Für Tierernährung,2002,56(1):33-40.

[4] ZHAO H-M,WANG Y,HUANG X-Y,et al.Astragalus polysaccharide attenuates rat experimental colitis by inducing regulatory T cells in intestinal Peyer's patches[J].World Journal of Gastroenterology,2016,22(11):3175

[5] MOLINA N,MORANDI A C,BOLIN A P,et al.Comparative effect of fucoxanthin and vitamin C on oxidative and functional parameters of human lymphocytes[J].International Immunopharmacology,2014,22(1):41-50.

[6] 周显青,牛翠娟,孙儒泳.维生素C和E混合饲喂对中华鳖幼鳖抗酸应激能力的影响[J].动物学研究,2004,25(1):37-42.

[7] ZHU L H,ZHAO K L,CHEN X L,et al.Impact of weaning and an antioxidant blend on intestinal barrier function and antioxidant status in pigs[J].Journal of Animal Science,2012,90(8):2581-2589.

[8] XU J,XU C,CHEN X,et al.Regulation of an antioxidant blend on intestinal redox status and major microbiota in early weaned piglets[J].Nutrition,2014,30(5):584-589.

[9] 叶文贵,林兆京.黄芪多糖预防断奶仔猪腹泻的效果试验[J].畜禽业,2007,(03):15-16.

[10] 王春华,何宇喜.维生素E及中草药对转群仔猪抗应激能力影响[J].饲料研究,2013,(3):83-84.

[11] DE RODAS B Z,MAXWELL C V,DAVIS M E,et al.L-ascorbyl-2-polyphosphate as a vitamin C source for segregated and conventionally weaned pigs[J].Journal of Animal Science,1998,76(6):1636-1643.

[12] WANG J P,YOO J S,KIM H J,et al.Nutrient digestibility, blood profiles and fecal microbiota are influenced by chitooligosaccharide supplementation of growing pigs[J].Livestock Science,2009,125(2/3):298-303.

[13] COMA J,CARRION D,ZIMMERMAN D R.Use of plasma urea nitrogen as a rapid response criterion to determine the lysine requirement of pigs[J].Journal of Animal Science,1995,73(2):472-481.

[14] HARVEY R,KUBENA L,ELISSALDE M.Influence of vitamin E on aflatoxicosis in growing swine[J].American Journal of Veterinary Research,1994,55(4):572-577.

[15] 彭宏刚,郑伟,潘晓亮.黄芪多糖对断奶仔猪生长性能和血清生化指标的影响[J].农村科技,2015(9):68-69.

[16] YI H,YU C,ZHANG H,et al.Cathelicidin-BF suppresses intestinal inflammation by inhibiting the nuclear factor-κB signaling pathway and enhancing the phagocytosis of immune cells via STAT-1 in weanling piglets[J].International Immunopharmacology,2015,28(1):61-69.

[17] CANTORNA M T, SNYDER L, LIN Y D, et al. Vitamin D and 1,25(OH)₂D regulation of T cells.[J].Nutrients,2015,7(4):3011-3021.

[18] 廖波,张克英,丁雪梅,等.饲粮添加25-羟基维生素D₃对轮状病毒攻毒和未攻毒断奶仔猪血清和肠内容物抗体和细胞因子水平的影响[J].动物营养学报,2011,23(1):34-42.

[19] FISCHER C P,HISCOCK N J,PENKOWA M,et al.Supplementation with vitamins C and E inhibits the release of interleukin-6 from contracting human skeletal muscle[J].Journal of Physiology,2004,558(2):633-645.

[20] SHIZUO A,KIYOSHI T. Toll-like receptor signalling[J].Journal of Biological Chemistry,2003,278(40):499-511.

[21] SERVET K,AYGUL G,LATIF D,et al.Effects of leflunomide on inflamation and fibrosis in bleomycine induced pulmonary fibrosis in wistar albino rats[J].Journal of Thoracic Disease,2013,5(5):641-649.

[22] ADAMCZAK D M,NOWAK J K,FRYDRYCHOWICZ M,et al.The role of Toll-like receptors and vitamin D in diabetes mellitus type 1-a review[J].Scandinavian Journal of Immunology,2014,80(2):75-84.

[23] URRY Z,XYSTRAKIS E,RICHARDS D F,et al.Ligation of TLR9 induced on human IL-10-secreting Tregs by 1α, 25-dihydroxyvitamin D₃ abrogates regulatory function[J].The Journal of Clinical Investigation,2009,119(2):387-398.

[24] CANALI R,NATARELLI L,LEONI G,et al.Vitamin C supplementation modulates gene expression in peripheral blood mononuclear cells specifically upon an inflammatory stimulus:a pilot study in healthy subjects[J].Genes & Nutrition,2014,9(3):390-390.

[25] YAO X,CARLSON D,SUN Y,et al.Mitochondrial ROS induces cardiac inflammation via a pathway through mtDNA damage in a pneumonia-related sepsis model[J].PloS One,2015,10(10):e0139416.

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