Progress in Molecular Signaling Pathway of Skeletal Muscle Fiber Type Transformation and Its Nutritional Regulation

GUO Qiuping, WEN Chaoyue, WANG Wenlong, DUAN Yehui, LI Yinghui, LI Fengna

doi:10.3969/j.issn.1006-267x.2017.06.002

Chinese Journal of Animal Nutrition >

2017 , Vol. 29 >Issue 6: 1836 - 1842

DOI: https://doi.org/10.3969/j.issn.1006-267x.2017.06.002

Molecular Nutrition

Progress in Molecular Signaling Pathway of Skeletal Muscle Fiber Type Transformation and Its Nutritional Regulation

Expand

1. Key Laboratory of Agro-Ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;
2. Graduate University of Chinese Academy of Sciences, Beijing 100049, China;
3. Laboratory of Animal Nutrition and Human Health, College of Life Science, Hunan Normal University, Changsha 410006, China;
4. Hunan Collaborative Innovation Center for Products Safety of Livestock and Poultry, Changsha 410128, China

Received date: 2016-12-14

Online published: 2017-06-07

Fold

Abstract

Skeletal muscle is made up of different types of muscle fibers which characterized by the myosin heavy chain isoform composition and consists of up to four main types:Ⅰ, Ⅱa, Ⅱx and Ⅱb. The composition of muscle fiber type in skeletal muscle influences the meat quality after animal slaughter. The skeletal muscle fiber type transformation can be regulated by different signaling pathways and regulatory factors in vivo and also by nutritional factors in diet. This review summarized the underlying signaling pathways and certain nutritional factors, for reference in understanding of improving meat quality through nutritional intervention.

Key words： skeletal muscle; muscle fiber type transformation; signaling pathway; nutritional regulation; meat quality

Cite this article

GUO Qiuping, WEN Chaoyue, WANG Wenlong, DUAN Yehui, LI Yinghui, LI Fengna . Progress in Molecular Signaling Pathway of Skeletal Muscle Fiber Type Transformation and Its Nutritional Regulation[J]. Chinese Journal of Animal Nutrition, 2017 , 29(6) : 1836 -1842 . DOI: 10.3969/j.issn.1006-267x.2017.06.002

References

[1] ASHMORE C R,DOERR L.Comparative aspects of muscle fiber types in different species[J].Experimental Neurology,1971,31(3):408-418.

[2] LISTRAT A,LEBRET B,LOUVEAU I,et al.How Muscle structure and composition influence meat and flesh quality[J].Scientific World Journal,2016,2016:3182746.

[3] PICARD B,LEFAUCHEUR L,BERRI C,et al.Muscle fibre ontogenesis in farm animal species[J].Reproduction Nutrition Development,2002,42(5):415-431.

[4] PETTE D,STARON R S.Transitions of muscle fiber phenotypic profiles[J].Histochemistry and Cell Biology,2001,115(5):359-372.

[5] HOPPELER H.Molecular networks in skeletal muscle plasticity[J].Journal of Experimental Biology,2016,219(2):205-213.

[6] SUWA M,NAKANO H,KUMAGAI S.Effects of chronic AICAR treatment on fiber composition,enzyme activity,UCP3,and PGC-1 in rat muscles[J].Journal of Applied Physiology,2003,95(3):960-968.

[7] 文超越,段叶辉,李颖慧,等.能量感应网络AMPK/SIRT1/PGC-lα对骨骼肌纤维类型转化调节[J].动物营养学报,2016,28(1):57-63.

[8] LIN J D,WU H,TARR P T,et al.Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres[J].Nature,2002,418(6899):797-801.

[9] ARANY Z,LEBRASSEUR N,MORRIS C,et al.The transcriptional coactivator PGC-1β drives the formation of oxidative type ⅡX fibers in skeletal muscle[J].Cell Metabolism,2007,5(1):35-46.

[10] 于亮,张鹏,王瑞元,等.PGC-1α对骨骼肌肌纤维类型及运动能力的调控作用[J].生理科学进展,2013,44(1):59-62.

[11] CANTÓ C,JIANG L Q,DESHMUKH A S,et al.Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle[J].Cell Metabolism,2010,11(3):213-219.

[12] CHALKIADAKI A,IGARASHI M,NASAMU A S,et al.Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy[J].PLoS Genetics,2014,10(7):e1004490.

[13] WALTERS E H,STICKLAND N C,LOUGHNA P T.MRF-4 exhibits fiber type- and muscle-specific pattern of expression in postnatal rat muscle[J].American Journal of Physiology:Regulatory,Integrative and Comparative Physiology,2000,278(5):R1381-R1384.

[14] 刘蓓蓓,卢健.SIRT1对肌卫星细胞和骨骼肌再生的影响[J].中国运动医学杂志,2013,32(3):275-280,274.

[15] CHIN E R.Role of Ca²⁺/calmodulin-dependent kinases in skeletal muscle plasticity[J].Journal of Applied Physiology,2005,99(2):414-423.

[16] SWOAP S J,HUNTER R B,STEVENSON E J,et al.The calcineurin-NFAT pathway and muscle fiber-type gene expression[J].American Journal of Physiology:Cell Physiology,2000,279(4):C915-C924.

[17] 吴金富.Ca²⁺/CaN途径在悬吊再负荷大鼠肌纤维类型转化中的作用[D].硕士学位论文.北京:北京体育大学,2010:42-47.

[18] 贾安峰,冯京海,张敏红.调控骨骼肌肌纤维类型转化的因素及机制[J].动物营养学报,2014,26(5):1151-1156.

[19] MCCULLAGH K J A,CALABRIA E,PALLAFACCHINA G,et al.NFAT is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switching[J].Proceedings of the National Academy of Sciences of the United States of America,2004,101(29):10590-10595.

[20] 张楠.运动对AMPK不同基因型小鼠骨骼肌PGC1-MEF2的影响[D].硕士学位论文.北京:北京体育大学,2011:26-31.

[21] RANEY M A,TURCOTTE L P.Evidence for the involvement of CaMKⅡ and AMPK in Ca²⁺-dependent signaling pathways regulating FA uptake and oxidation in contracting rodent muscle[J].Journal of Applied Physiology,2008,104(5):1366-1373.

[22] BABA M,HONG S B,SHARMA N,et al.Folliculin encoded by the BHD gene interacts with a binding protein,FNIP1,and AMPK,and is involved in AMPK and mTOR signaling[J].Proceedings of the National Academy of Sciences of the United States of America,2006,103(42):15552-15557.

[23] PARK H,STAEHLING K,TSANG M,et al.Disruption of Fnip1 reveals a metabolic checkpoint controlling B lymphocyte development[J].Immunity,2012,36(5):769-781.

[24] REYES N L,BANKS G B,TSANG M,et al.Fnip1 regulates skeletal muscle fiber type specification,fatigue resistance,and susceptibility to muscular dystrophy[J].Proceedings of the National Academy of Sciences of the United States of America,2014,112(2):424-429.

[25] SCHACHTER T N,SHEN T S,LIU Y G,et al.Kinetics of nuclear-cytoplasmic translocation of FoxO1 and FoxO3A in adult skeletal muscle fibers[J].American Journal of Physiology:Cell Physiology,2012,303(9):C977-C990.

[26] KOUSTENI S.FoxO1,the transcriptional chief of staff of energy metabolism[J].Bone,2012,50(2):437-443.

[27] KAMEI Y,MIURA S,SUZUKI M,et al.Skeletal muscle FoxO1(FKHR) transgenic mice have less skeletal muscle mass,down-regulated type Ⅰ (slow twitch/red muscle) fiber genes,and impaired glycemic control[J].Journal of Biological Chemistry,2004,279(39):41114-41123.

[28] 史新娥,郑雪莉,刘月光,等.慢病毒介导shRNA干扰FoxO1促进猪成肌细胞中MyHCⅠ的表达[J].中国生物化学与分子生物学报,2011,27(6):582-588.

[29] 张辉,史新娥,袁媛,等.FoxO1抑制猪骨骼肌MyHCⅠ的表达[J].中国生物化学与分子生物学报,2010,26(3):283-289.

[30] AZAD M,KHALEDI N,HEDAYATI M.Effect of acute and chronic eccentric exercise on FoxO1 mRNA expression as fiber type transition factor in rat skeletal muscles[J].Gene,2016,584(2):180-184.

[31] WANG Y X,ZHANG C L,YU R T,et al.Regulation of muscle fiber type and running endurance by PPARδ[J].PLoS Biology,2004,2(10):e294.

[32] LUQUET S,LOPEZ-SORIANO J,HOLST D,et al.Peroxisome proliferator-activated receptor δ controls muscle development and oxidative capability[J].The FASEB Journal,2003,17(15):2299-2301.

[33] RUSSELL A P,FEILCHENFELDT J,SCHREIBER S,et al.Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-γ coactivator-1 and peroxisome proliferator-activated receptor-α in skeletal muscle[J].Diabetes,2003,52(12):2874-2881.

[34] SCHULER M,ALI F,CHAMBON C,et al.PGC1α expression is controlled in skeletal muscles by PPARβ,whose ablation results in fiber-type switching,obesity,and type 2 diabetes[J].Cell Metabolism,2006,4(5):407-414.

[35] JUNG S,KIM K.Exercise-induced PGC-1α transcriptional factors in skeletal muscle[J].Integrative Medicine Research,2014,3(4):155-160.

[36] GAN Z J,RUMSEY J,HAZEN B C,et al.Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism[J].The Journal of Clinical Investigation,2013,123(6):2564-2575.

[37] VACCA R A,VALENTI D,CACCAMESE S,et al.Plant polyphenols as natural drugs for the management of down syndrome and related disorders[J].Neuroscience & Biobehavioral Reviews,2016,71:865-877.

[38] 周艳.杜仲叶多酚提取物对猪肉品质及绿原酸缓解肝--肠损伤研究[D].博士学位论文.南昌:南昌大学,2015:33-34.

[39] 于亮,陈晓萍,王瑞元.4周红景天、红景天苷灌胃对小鼠骨骼肌纤维类型的影响及机制[J].北京体育大学学报,2014(6):54-58.

[40] MIZUNOYA W,MIYAHARA H,OKAMOTO S,et al.Improvement of endurance based on muscle fiber-type composition by treatment with dietary apple polyphenols in rats[J].PLoS One,2015,10(7):e0134303.

[41] MIZUNOYA W,OKAMOTO S,MIYAHARA H,et al.Fast-to-slow shift of muscle fiber-type composition by dietary apple polyphenols in rats:impact of the low-dose supplementation[J].Animal Science Journal,2016,doi:10.1111/asj.12655.

[42] MURASE T,HARAMIZU S,SHIMOTOYODOME A,et al.Green tea extract improves endurance capacity and increases muscle lipid oxidation in mice[J].American Journal of Physiology:Regulatory,Integrative and Comparative Physiology,2005,288(3):R708-R715.

[43] 王丽娜,王珍,彭建龙,等.表没食子儿茶素没食子酸酯对育肥猪骨骼肌纤维类型的影响[J].畜牧兽医学报,2016,47(8):1581-1591.

[44] HARRISON A P,ROWLERSON A M,DAUNCEY M J.Selective regulation of myofiber differentiation by energy status during postnatal development[J].The American Journal of Physiology,1996,270(3 Pt 2):R667-R674.

[45] LEFAUCHEUR L.A second look into fibre typing-relation to meat quality[J].Meat Science,2010,84(2):257-270.

[46] LI Y J,LI J L,ZHANG L,et al.Effects of dietary energy sources on Post mortem glycolysis,meat quality and muscle fibre type transformation of finishing pigs[J].PLoS One,2015,10(6):E0131958.

[47] 孙相俞.不同品种和营养水平对猪肌纤维类型和胴体肉质性状的影响[D].硕士学位论文.雅安:四川农业大学,2009:31-32

[48] 陈佳.日粮蛋白水平对杜约八三元杂交猪生长性能和肉质性状的影响[D].硕士学位论文.杨凌:西北农林科技大学,2016:25-26.

[49] LI Y H,LI F N,WU L,et al.Effects of dietary protein restriction on muscle fiber characteristics and mTORC1 pathway in the skeletal muscle of growing-finishing pigs[J].Journal of Animal Science and Biotechnology,2016,7(1):47.

[50] 杨飞云,陈代文,黄金秀,等.猪背最长肌肌纤维类型的发育性变化及品种与营养影响特点[J].畜牧兽医学报,2008,39(12):1701-1708.

[51] KAWABATA F,MIZUSHIGE T,UOZUMI K,et al.Fish protein intake induces fast-muscle hypertrophy and reduces liver lipids and serum glucose levels in rats[J].Bioscience,Biotechnology,and Biochemistry,2015,79(1):109-116.

[52] YOSHIHARA H,WAKAMATSU J,KAWABATA F,et al.Beef extract supplementation increases leg muscle mass and modifies skeletal muscle fiber types in rats[J].Journal of Nutritional Science and Vitaminology,2006,52(3):183-193.

[53] 任阳.饱和与不饱和脂肪酸对猪肌纤维组成的影响及其AMPK途径研究[D].博士学位论文.杭州:浙江大学,2014:95.

[54] 田春庄.鱼油上调断奶仔猪肌纤维类型及相关基因表达促进肌肉生长的研究[D].硕士学位论文.武汉:华中农业大学,2008:55.

[55] MIZUNOYA W,IWAMOTO Y,SHIROUCHI B,et al.Dietary fat influences the expression of contractile and metabolic genes in rat skeletal muscle[J].PLoS One,2013,8(11):e80152.

[56] ALONSO-MARTIN S,ROCHAT A,MADEMTZOGLOU D,et al.Gene expression profiling of muscle stem cells identifies novel regulators of postnatal myogenesis[J].Frontiers in Cell and Developmental Biology,2016,4:58.

[57] SCHULTZ E.Satellite cell behavior during skeletal muscle growth and regeneration[J].Medicine and Science in Sports and Exercise,1989,21(Suppl.5):S181-S186.

[58] HONG Y,PAN Y,EBNER P D.Meat science and muscle biology symposium:development of bacteriophage treatments to reduce Escherichia coli O157:H7 contamination of beef products and produce[J].Journal of Animal Science,2014,92(4):1366-1377.

Options

Outlines

模态框（Modal）标题

Abstract

Cite this article

References