This experiment was conducted to investigate the effects of giseng polysaccharide on growth performance, nutrient digestibility, nitrogen metabolism and serum biochemical indices of minks during growing period. The experiment was designed in a single factor. Forty 70-day-old healthy male minks with similar body weight were randomly divided into 4 groups with 10 replicates per replicate and 1 mink per replicate. The control group (group Ⅰ) was fed a basal diet, and groups Ⅱ, Ⅲ and Ⅳ were fed the experimental diets supplemented with 10, 50 and 100 mg/kg giseng polysaccharide (based on dry matter), respectively. The pretest period lasted for 7 days and the formal period lasted for 60 days. The results showed as follows:1) the final body weight (body weight at 130 days of age) and average daily gain in group Ⅳ was significantly higher than those in control group (P<0.05); the ratio of feed to gain (F/G) was decreased with the giseng polysaccharide supplemental level increasing, and the F/G of group Ⅳ was significantly lower than that in control group and group Ⅱ (P<0.05). 2) The dry matter output in group Ⅳ was significantly lower than that in control group and group Ⅱ (P<0.05), the dry matter digestibility and crude protein digestibility in groups Ⅲ and Ⅳ were significantly higher than those in control group (P<0.05 or P<0.01), no significant difference was found in crude fat digestibility among all groups (P>0.05). 3) No significant difference was found in nitrogen intake, fecal nitrogen, urine nitrogen and nitrogen retention among all groups (P>0.05); the net protein utilization was increased with the giseng polysaccharide supplemental level increasing, and the net protein utilization in group Ⅳ was significantly higher than that in control group (P<0.05). 4) The serum albumin content in groups Ⅱ, Ⅲ and Ⅳ was significantly higher than that in control group (P<0.01), the content of total protein, globulin and immunoglobulin M in serum was significantly higher than that in control group (P<0.05), no significant difference was found in the content of immunoglobulin M, immunoglobulin A, total cholesterol, triglycerides and glucose in serum among all groups (P>0.05). In conclusion, dietary supplemented with giseng polysaccharide can increase the net protein utilization of minks, then improve the dry matter digestibility and crude protein digestibility, regulate the serum immunoglobulin M content, enhance immunity, and improve the growth performance.