Molecular Nutrition

Regulation and Mechanism of Transforming Growth Factor-β1/Smads Signaling Pathway on Development of Ovaries in Mammalian

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  • 1. Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China;
    2. Tai'an Central Hospital, Tai'an 271000, China

Received date: 2017-01-15

  Online published: 2017-07-05

Abstract

The normally operation of the program within the body is depend on the coordination among different signal transduction pathways. transforming growth factor (TGF)-β1/Smads signaling pathway among numerous pathways has received increasing attention by scholars and became a research hot point in molecular and cell biology. It has been confirmed that TGF-β1/Smads signaling pathway is the indispensible way to regulate the development of ovarian follcles. In this paper, the regulatory role and mechanism of TGF-β1/Smads signaling pathway in mammalian ovarian development were reviewed in aspect of TGF-β receptor, Smads protein, bone morphogenetic protein (BMP), thrombospondin 1 (THB-S1), S-phase kinase association protein 1 (SKP1) and other regulatory mechanism. This review is aim to draw attention to the regulation of TGF-β1/Smads in ovarian development and provide some reference for the treatment of some diseases during ovarian development.

Cite this article

ZHOU Min, FENG Qiang, HUANG Libo, YANG Zaibin, YANG Weiren, JIANG Shuzhen . Regulation and Mechanism of Transforming Growth Factor-β1/Smads Signaling Pathway on Development of Ovaries in Mammalian[J]. Chinese Journal of Animal Nutrition, 2017 , 29(7) : 2283 -2288 . DOI: 10.3969/j.issn.1006-267x.2017.07.010

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