[1] LEWIS K.Platforms for antibiotic discovery[J].Nature Reviews Drug Discovery,2013,12(5):371-387.

[2] FOX J L.Antimicrobial peptides stage a comeback[J].Nature Biotechnology,2013,31(5):379-382.

[3] WILMES M,STOCKEM M,BIERBAUM G,et al.Killing of staphylococci by θ-defensins involves membrane impairment and activation of autolytic enzymes[J].Antibiotics (Basel),2014,3(4):617-631.

[4] NGUYEN L T,HANEY E F,VOGEL H J.The expanding scope of antimicrobial peptide structures and their modes of action[J].Trends in Biotechnology,2011,29(9):464-472.

[5] TEIXEIRA V,FEIO M J,BASTOS M.Role of lipids in the interaction of antimicrobial peptides with membranes[J].Progress in Lipid Research,2012,51(2):149-177.

[6] WIMLEY W C.Describing the mechanism of antimicrobial peptide action with the interfacial activity model[J].ACS Chemical Biology,2010,5(10):905-917.

[7] GRAY A N,EGAN A J F,VAN'T VEER I L,et al.Coordination of peptidoglycan synthesis and outer membrane constriction during
Escherichia coli cell division[J].eLife Sciences,2015,4:e07118.
[8] NEUHAUS F C,BADDILEY J.A continuum of anionic charge:structures and functions of
D-alanyl-teichoic acids in gram-positive bacteria[J].Microbiology and Molecular Biology Reviews,2003,67(4):686-723.

[9] SCHNEIDER T,KRUSE T,WIMMER R,et al.Plectasin,a fungal defensin,targets the bacterial cell wall precursor lipid Ⅱ[J].Science,2010,328(5982):1168-1172.

[10] HASPER H E,KRAMER N E,SMITH J L,et al.An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid Ⅱ[J].Science,2006,313(5793):1635-1637.
[11] SASS V,SCHNEIDER T,WILMES M,et al.Human β-defensin 3 inhibits cell wall biosynthesis in staphylococci[J].Infection and Immunity,2010,78(6):2793-2800.

[12] DE LEEUW E,LI C Q,ZENG P Y,et al.Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid Ⅱ[J].FEBS Letters,2010,584(8):1543-1548.

[13] LEE H,HWANG J S,LEE J,et al.Scolopendin 2,a cationic antimicrobial peptide from centipede,and its membrane-active mechanism[J].Biochimica et Biophysica Acta (BBA):Biomembranes,2015,1848(2):634-642.

[14] WANG K R,DANG W,YAN J X,et al.Membrane perturbation action mode and structure-activity relationships of Protonectin,a novel antimicrobial peptide from the venom of the neotropical social wasp
Agelaia pallipes pallipes[J].Antimicrobial Agents and Chemotherapy,2013,57(10):4632-4639.

[15] BARNS K J,WEISSHAAR J C.Real-time attack of LL-37 on single
Bacillus subtilis cells[J].Biochimica et Biophysica Acta:Biomembranes,2013,1828(6):1511-1520.

[16] RANGARAJAN N,BAKSHI S,WEISSHAAR J C.Localized permeabilization of
E. coli membranes by the antimicrobial peptide Cecropin A[J].Biochemistry,2013,52(38):6584-6594.
[17] MILEYKOVSKAYA E,DOWHAN W.Cardiolipin membrane domains in prokaryotes and eukaryotes[J].Biochimica et Biophysica Acta:Biomembranes,2009,1788(10):2084-2091.

[18] LUTKENHAUS J,PICHOFF S,DU S S.Bacterial cytokinesis:from Z ring to divisome [J].Cytoskeleton,2012,69(10):778-790.

[19] POGLIANO J,POGLIANO N,SILVERMAN J A.Daptomycin-mediated reorganization of membrane architecture causes mislocalization of essential cell division proteins[J].Journal of Bacteriology,2012,194(17):4494-4504.

[20] WENZEL M,CHIRIAC A I,OTTO A,et al.Small cationic antimicrobial peptides delocalize peripheral membrane proteins[J].Proceedings of the National Academy of Sciences of the United States of America,2014,111(14):E1409-E1418.

[21] GHOSH A,KAR R K,JANA J,et al.Indolicidin targets duplex DNA:structural and mechanistic insight through a combination of spectroscopy and microscopy[J].ChemMedChem,2014,9(9):2052-2058.

[22] DANGEL A,ACKERMANN N,ABDEL-HADI O,et al.A
de novo-designed antimicrobial peptide with activity against multiresistant
Staphylococcus aureus acting on RsbW kinase[J].The FASEB Journal,2013,27(11):4476-4488.

[23] SETLOW P.Germination of spores of
Bacillus species:what we know and do not know[J].Journal of Bacteriology,2014,196(7):1297-1305.

[24] GUT I M,BLANKE S R,VAN DER DONK W A.Mechanism of inhibition of
Bacillus anthracis spore outgrowth by the lantibiotic nisin[J].ACS Chemical Biology,2011,6(7):744-752.

[25] YANG S J,NAST C C,MISHRA N N,et al.Cell wall thickening is not a universal accompaniment of the daptomycin nonsusceptibility phenotype in
Staphylococcus aureus:evidence for multiple resistance mechanisms[J].Antimicrobial Agents and Chemotherapy,2010,54(8):3079-3085.

[26] BAYER A S,MISHRA N N,SAKOULAS G,et al.Heterogeneity of
mprF sequences in methicillin-resistant
Staphylococcus aureus clinical isolates:role in cross-resistance between daptomycin and host defense antimicrobial peptides[J].Antimicrobial Agents and Chemotherapy,2014,58(12):7462-7467.

[27] CUI LZ,MURAKAMI H,KUWAHARA-ARAI K,et al.Contribution of a thickened cell wall and its glutamine nonamidated component to the vancomycin resistance expressed by
Staphylococcus aureus Mu50[J].Antimicrobial Agents and Chemotherapy,2000,44(9):2276-2285.

[28] CUI L Z,MA X X,SATO K,et al.Cell wall thickening is a common feature of vancomycin resistance in
Staphylococcus aureus[J].Journal of Clinical Microbiology,2003,41(1):5-14.

[29] MISHRA N N,BAYER A S,TRAN T T,et al.Daptomycin resistance in enterococci is associated with distinct alterations of cell membrane phospholipid content[J].PLoS One,2012,7(8):e43958.

[30] MISHRA N N,BAYER A S.Correlation of cell membrane lipid profiles with daptomycin resistance in methicillin-resistant
Staphylococcus aureus[J].Antimicrobial Agents and Chemotherapy,2013,57(2):1082-1085.

[31] MCBRIDE S M,SONENSHEIN A L.The
dlt operon confers resistance to cationic antimicrobial peptides in Clostridium
difficile[J].Microbiology,2011,157(5):1457-1465.

[32] ROSE W E,FALLON M,MORAN J J M,et al.Vancomycin tolerance in methicillin-resistant
Staphylococcus aureus:influence of vancomycin,daptomycin,and telavancin on differential resistance gene expression[J].Antimicrobial Agents and Chemotherapy,2012,56(8):4422-4427.

[33] PELEG A Y,MIYAKIS S,WARD D V,et al.Whole genome characterization of the mechanisms of daptomycin resistance in clinical and laboratory derived isolates of
Staphylococcus aureus[J].PLoS One,2012,7(1):e28316.

[34] COX E,MICHALAK A,PAGENTINE S,et al.Lysylated phospholipids stabilize models of bacterial lipid bilayers and protect against antimicrobial peptides[J].Biochimica et Biophysica Acta:Biomembranes,2014,1838(9):2198-2204.

[35] PESCHEL A,SAHL H G.The co-evolution of host cationic antimicrobial peptides and microbial resistance[J].Nature Reviews Microbiology,2006,4(7):529-536.

[36] JORDAN S,HUTCHINGS M I,MASCHER T.Cell envelope stress response in Gram-positive bacteria[J].FEMS Microbiology Reviews,2008,32(1):107-146.

[37] KINGSTON A W,SUBRAMANIAN C,ROCK C O,et al.A σ
W-dependent stress response in
Bacillus subtilis that reduces membrane fluidity[J].Molecular Microbiology,2011,81(1):69-79.

[38] PIETIÄINEN M,GARDEMEISTER M,MECKLIN M,et al.Cationic antimicrobial peptides elicit a complex stress response in
Bacillus subtilis that involves ECF-type sigma factors and two-component signal transduction systems[J].Microbiology,2005,151(5):1577-1592.

[39] EIAMPHUNGPORN W,HELMANN J D.The
Bacillus subtilis σ
M regulon and its contribution to cell envelope stress responses[J].Molecular Microbiology,2008,67(4):830-848.

[40] CAO M,HELMANN J D.The
Bacillus subtilis extracytoplasmic-function σ
X factor regulates modification of the cell envelope and resistance to cationic antimicrobial peptides[J].Journal of Bacteriology,2004,186(4):1136-1146.

[41] OHKI R,GIYANTO,TATENO K,et al.The BceRS two-component regulatory system induces expression of the bacitracin transporter,BceAB,in
Bacillus subtilis[J].Molecular Microbiology,2003,49(4):1135-1144.

[42] STARO N' A,FINKEISON D E,Mascher T.Peptide antibiotic sensing and detoxification modules of
Bacillus subtilis[J].Antimicrobial Agents and Chemotherapy,2011,55(2):515-525.

[43] LI M,LAI Y P,VILLARUZ A E,et al.Gram-positive three-component antimicrobial peptide-sensing system[J].Proceedings of the National Academy of Sciences of the United States of America,2007,104(22):9469-9474.

[44] YANG S J,BAYER A S,MISHRA N N,et al.The
Staphylococcus aureus two-component regulatory system,GraRS,senses and confers resistance to selected cationic antimicrobial peptides [J].Infection and Immunity,2012,80(1):74-81.

[45] GRUENHEID S,LE MOUAL H.Resistance to antimicrobial peptides in Gram-negative bacteria[J].FEMS Microbiology Letters,2012,330(2):81-89.